Background: Lung cancer ranks first among cancer-related deaths worldwide and is one of the most common malignant tumors. Chemotherapy is a critical treatment modality for lung cancer, but its treatment-related adverse effects are common and often lead to significant psychological distress, including anxiety and depression. These negative emotions impose a heavy psychological burden and are closely associated with self-efficacy, quality of life, and well-being. The PERMA model, which consists of five elements -Positive Emotion (P), Engagement (E), Relationships (R), Meaning (M), and Accomplishment (A), is a happiness model based on positive psychology. The PERMA model can enhance patients’ positive emotions and alleviate negative emotions. At present, the positive effects of psychological interventions based on the PERMA model have been clinically validated in the field of cancer, but research in patients undergoing chemotherapy for lung cancer remains limited. Objective: To explore the effects of psychological intervention based on the PERMA model on self-efficacy, quality of life, and well-being in lung cancer patients receiving chemotherapy. Methods: 90 lung cancer patients who were admitted for their first chemotherapy at a tertiary hospital between June 2024 and October 2024 were enrolled as study subjects. They were randomly assigned into a control group and an intervention group, with 45 patients in each group using the random number table method. The control group received routine nursing care, while the intervention group received PERMA-based psychological intervention in addition to routine care for eight weeks. Outcomes were assessed using the Strategies Used by People to Promote Health (SUPPH) scale for self-efficacy, the Quality of Life Instruments for Cancer Patients-Lung Cancer (QLICP-LU) for quality of life, and the Index of Well-Being (IWB) for overall well-being. Measurements were taken at baseline, immediately after the intervention, and one month after the intervention. Results: At baseline, no statistically significant differences were found between the two groups in SUPPH, QLICP-LU, and IWB scores (P>0.05). Immediately after the intervention and at one-month follow-up, the intervention group demonstrated significantly higher SUPPH scores across all dimensions and total scores compared with the control group (P<0.05). Similarly, the intervention group had significantly higher QLICP-LU total scores and IWB total scores than the control group at both time points (P<0.05). Conclusion: PERMA-based psychological intervention effectively enhances self-efficacy, quality of life, and well-being in lung cancer patients undergoing chemotherapy, providing scientific evidence for psychological interventions in clinical practice.

PERMA Model, Lung Cancer, Chemotherapy, Self-efficacy, Quality of Life, Well-being