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The Evaluation of Oral Health in Patients with Chronic Kidney Disease – A Longitudinal Study

Background: Chronic kidney disease affects more than 10% of people globally. The aim of the study was to assess oral health in patients with chronic kidney disease. The sample was composed of 233 patients, of which 147 (63%) were males and 86 (37%) were females. Participants' age varied from 31 to 70 years old. We divided the participants into four age groups: 31-40, 41-50, 51-60, and 61-70 years old. Data were analyzed by using (IBM, New York, USA, SPSS Statistics for Windows), Version 23.0. The significance level (α) was set at 0.05, with a confidence interval (CI) of 95%. The prevailing age range was from 51 to 60 years old, with 31.8% of the participants. A considerable number of patients with chronic kidney disease had low incomes, respectively 42.4% of them. 80.7% of the patients were current smokers and 73.4% of them consumed alcohol. A large proportion of respondents 83.7% of them were diabetic patients. 63.1% of the participants reported that they had hypertension. According to our findings, 55.8% of the participants brush their teeth only once a day. The study found a strong correlation between chronic kidney disease and diabetes mellitus (CI 95; 1.17-1.33, P-value ˂.0001), hypertension (P ˂.0001), alcohol consumption (P=.001), and smoking (P =.000). Gingivitis was the most common oral disease which affected 73.4% of the participants, followed by 56.7% of them who had dental caries.

Alcohol Consumption, Chronic Kidney Disease, Dental Caries, Diabetes Mellitus, Gingivitis, Hypertension

Mimoza Canga, Irene Malagnino, Edit Xhajanka, Rozela Xhemnica, Vergjini Mulo, et al. (2023). The Evaluation of Oral Health in Patients with Chronic Kidney Disease – A Longitudinal Study. International Journal of Biomedical Engineering and Clinical Science, 9(1), 1-5.

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Luyckx, V., Tonelli, M., & Stanifer, J. (2018). La carga global de la insuficiencia renal y los objetivos de desarrollo sostenible. Boletín de la Organización Mundial de la Salud, 96 (6), 369-440.
2. Lv, J. C., & Zhang, L. X. (2019). Prevalence and disease burden of chronic kidney disease. Renal Fibrosis: Mechanisms and Therapies, 3-15. doi: 10.1007/978-981-13-8871-2_1.
3. Pecoits-Filho, R., Abensur, H., Betônico, C. C., Machado, A. D., Parente, E. B., Queiroz, M., & Vencio, S. (2016). Interactions between kidney disease and diabetes: dangerous liaisons. Diabetology & metabolic syndrome, 8 (1), 1-21. doi: 10.1186/s13098-016-0159-z.
4. Chen, L., Wang, J., Huang, X., Wang, F., Liang, W., He, Y., & Xiong, Z. (2020). Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). Health and quality of life outcomes, 18 (1), 1-8. doi: 10.1186/s12955-020-01519-5.
5. Hanratty, R., Chonchol, M., Havranek, E. P., Powers, J. D., Dickinson, L. M., Ho, P. M., & Steiner, J. F. (2011). Relationship between blood pressure and incident chronic kidney disease in hypertensive patients. Clinical journal of the American Society of Nephrology, 6 (11), 2605-2611. doi: 10.2215/CJN.02240311.
6. Cantero-Navarro, E., Rayego-Mateos, S., Orejudo, M., Tejedor-Santamaria, L., Tejera-Muñoz, A., Sanz, A. B., & Ruiz-Ortega, M. (2021). Role of macrophages and related cytokines in kidney disease. Frontiers in medicine, 8, 1037. doi: 10.1038/s41581-019-0248-y.
7. Tonelli M, Riella M. (2014). Chronic kidney disease and the aging population. Brazilian Journal of Nephrology, 36: 1-5.
8. Palygin, O., Guan, Z., Intapad, S., & Sullivan, J. C. (2021). Hypertension and Chronic Kidney Injury or Failure. Frontiers in Physiology, 12, 662737. doi: 10.3389/fphys.2021.662737.
9. Yim, H. E., & Yoo, K. H. (2021). Obesity and chronic kidney disease: prevalence, mechanism, and management. Clinical and Experimental Pediatrics, 64 (10), 511. doi: 10.3345/cep.2021.00108.
10. Memarian, E., Nilsson, P. M., Zia, I., Christensson, A., & Engström, G. (2021). The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study. BMC nephrology, 22 (1), 1-10. doi: 10.1186/s12882-021-02531-7.
11. Xia, J., Wang, L., Ma, Z., Zhong, L., Wang, Y., Gao, Y., & Su, X. (2017). Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies. Nephrology Dialysis Transplantation, 32 (3), 475-487. doi: 10.1093/ndt/gfw452.
12. Fan, Z., Yun, J., Yu, S., Yang, Q., & Song, L. (2019). Alcohol consumption can be a “double-edged sword” for chronic kidney disease patients. Medical science monitor: international medical journal of experimental and clinical research, 25, 7059. doi: 10.12659/MSM.916121.
13. Menezes, C. R., Pereira, A. L., Ribeiro, C. C., Chaves, C. O., Guerra, R. N., Thomaz, É. B.,... & Alves, C. M. (2019). Is there association between chronic kidney disease and dental caries? A case-controlled study. Medicina oral, patologia oral y cirugia bucal, 24 (2), e211. doi: 10.4317/medoral.22737.
14. Liu K, Liu Q, Chen W, Liang M, Luo W, Wu X, et al. Prevalence and risk factors of CKD in Chinese patients with periodontal disease. PLoS One. 2013; 8 (8): e70767. doi: 10.1371/journal.pone.0070767.
15. Gupta, M., & Gupta, M. (2015). Oral conditions in renal disorders and treatment considerations–A review for pediatric dentist. The Saudi dental journal, 27 (3), 113-119. doi: 10.1016/j.sdentj.2014.11.014.
16. Chang, Y., Lee, J. S., Woo, H. G., Ryu, D. R., Kim, J. W., & Song, T. J. (2021). Improved oral hygiene care and chronic kidney disease occurrence: A nationwide population-based retrospective cohort study. Medicine, 100 (47). doi: 10.1097/MD.0000000000027845.
17. Gutierrez, O. M. (2015). Contextual poverty, nutrition, and chronic kidney disease. Advances in chronic kidney disease, 22 (1), 31-38. doi: 10.1053/j.ackd.2014.05.005.
18. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. (2013). Jama, 310 (20): 2191-4. doi: 10.1001/jama.2013.281053.
19. Islam, T. M., Fox, C. S., Mann, D., & Muntner, P. (2009). Age-related associations of hypertension and diabetes mellitus with chronic kidney disease. BMC nephrology, 10 (1), 1-6. doi: 10.1186/1471-2369-10-17.
20. Yamada, T., Wakabayashi, M., Bhalla, A., Chopra, N., Miyashita, H., Mikami, T., & Tamura, K. (2021). Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta-analysis. Cardiovascular diabetology, 20 (1), 1-13. doi: 10.1186/s12933-020-01197-z.
21. Lakkis JI, Weir MR. (2018). Obesity and kidney disease. Progress in cardiovascular diseases, 61 (2): 157-67. doi: 10.1016/j.pcad.2018.07.005.
22. Chagnac, A., Zingerman, B., Rozen-Zvi, B., & Herman-Edelstein, M. (2019). Consequences of glomerular hyperfiltration: the role of physical forces in the pathogenesis of chronic kidney disease in diabetes and obesity. Nephron, 143 (1), 38-42. doi: 10.1159/000499486.
23. Chen, T. K., Knicely, D. H., & Grams, M. E. (2019). Chronic kidney disease diagnosis and management: a review. Jama, 322 (13), 1294-1304. doi: 10.1001/jama.2019.14745.
24. Grams, M. E., Rebholz, C. M., Chen, Y., Rawlings, A. M., Estrella, M. M., Selvin, E., & Coresh, J. (2016). Race, APOL1 risk, and eGFR decline in the general population. Journal of the American Society of Nephrology, 27 (9), 2842-2850. doi: 10.1681/ASN.2015070763.
25. Coresh, J., Eknoyan, G., & Levey, A. S. (2002). Estimating the prevalence of low glomerular filtration rate requires attention to the creatinine assay calibration. Journal of the American Society of Nephrology, 13 (11), 2811-2816. doi: 10.1097/01.asn.0000037420. 89149.c9.
26. Leonberg-Yoo, A. K., & Rudnick, M. R. (2017). Tobacco use: a chronic kidney disease accelerant. American Journal of Nephrology, 46 (4), 257-260. doi: 10.1159/000481209.
27. Hu, E. A., Lazo, M., Rosenberg, S. D., Grams, M. E., Steffen, L. M., Coresh, J., & Rebholz, C. M. (2020). Alcohol consumption and incident kidney disease: results from the atherosclerosis risk in community’s study. Journal of Renal Nutrition, 30 (1), 22-30. doi: 10.1053/j.jrn.2019.01.011.
28. Umesawa M, Sairenchi T, Haruyama Y, Nagao M, Yamagishi K, Irie F, et al. (2018). Validity of a risk prediction equation for CKD after 10 years of follow-up in a Japanese population: the Ibaraki prefectural health study. American journal of kidney diseases, 71 (6): 842-50. doi: 10.1053/j.ajkd.2017.09.013.
29. Kanda, E., Muneyuki, T., Suwa, K., & Nakajima, K. (2015). Alcohol and exercise affect declining kidney function in healthy males regardless of obesity: A prospective cohort study. PLoS One, 10 (8), e0134937. doi: 10.1371/journal.pone.0134937.
30. Menon, V., Katz, R., Mukamal, K., Kestenbaum, B., de Boer, I. H., Siscovick, D. S., & Shlipak, M. G. (2010). Alcohol consumption and kidney function decline in the elderly: alcohol and kidney disease. Nephrology Dialysis Transplantation, 25 (10), 3301-3307. doi: 10.1093/ndt/gfq188.
31. Andaloro C, Sessa C, Bua N, Mantia IL. (2018). Chronic kidney disease in children: Assessment of oral health status. Dental and medical problems, 55 (1): 23-8. doi: 10.17219/dmp/81747.
32. Kesmez, Ö., Frøjk, M. J., Eidemak, I., Jensen, S. B., & Kragelund, C. (2020). Oral symptoms and pathologies in Danish patients with chronic kidney disease-a pilot study. Apmis, 128 (5), 401-405. doi: 10.1111/apm.13042.