Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99mTc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99mTc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate.
| Published in | European Journal of Biophysics (Volume 12, Issue 1) |
| DOI | 10.11648/ejb.20241201.12 |
| Page(s) | 6-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hyperparathyroidism, Scintigraphy, 99mTc-MIBI, Senegal
| [1] | Taniegra ED. Hyperparathyroidism. Am Fam Physician 2004; 69: 333–9. |
| [2] | Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, et al. The EANM practice guidelines for parathyroid imaging. Eur J Nucl Med Mol Imaging 2021; 48: 2801–22. https://doi.org/10.1007/s00259-021-05334-y. |
| [3] | Minisola S, Arnold A, Belaya Z, Brandi ML, Clarke BL, Hannan FM, et al. Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism. J Bone Miner Res 2022; 37: 2315–29. https://doi.org/10.1002/jbmr.4665 |
| [4] | A. D. DIA et al. L’hyperparathyroïdie primaire à Dakar aspects diagnostiques et thérapeutiques. Médecine d’Afrique noire. 2015; vol 62, N°2.77-82http://www.santetropicale.com/manelec/fr/recherche.asp?fmc= (accessed September 8, 2023). |
| [5] | Niasse Moustapha. Hyperparathyroïdie primaire : étude de 22 observations au Sénégal Primary hyperparathyroidism: study of 22 observations in Senegal 2018. Rev Mar Rhum 2018; 46: 36-41 https://doi.org/10.24398/A.310.2019. |
| [6] | Foufouo N V. L’hyperparathyroïdie primaire à propos de 21 cas. Thèse de médecine. Université Cheikh Anta Diop de Dakar; 2016, 90p. |
| [7] | Ahmed Houra. Traitement chirurgicale de l’hyperparathyroïdie. Thèse de médecine. Université Cheikh Anta Diop de Dakar;2015,121p |
| [8] | Abood A, Vestergaard P. Increasing incidence of primary hyperparathyroidism in Denmark. Dan Med J 2013; 60: A4567. |
| [9] | Médecine du Maghreb électronique - Recherche d’articles par mots clés n.d. http://www.santetropicale.com/magelec/fr/recherche.asp (accessed September 9, 2023). |
| [10] | Paruk IM, Esterhuizen TM, Maharaj S, Pirie FJ, Motala AA. Characteristics, management and outcome of primary hyperparathyroidism in South Africa: a single-centre experience. Postgrad Med J 2013; 89: 626–31. https://doi.org/10.1136/postgradmedj-2012-131707. |
| [11] | Griebeler ML, Kearns AE, Ryu E, Hathcock MA, Melton LJ, Wermers RA. Secular Trends in the Incidence of Primary Hyperparathyroidism Over Five Decades (1965-2010). Bone 2015; 73: 1–7. https://doi.org/10.1016/j.bone.2014.12.003. |
| [12] | Lin X, Fan Y, Zhang Z, Yue H. Clinical Characteristics of Primary Hyperparathyroidism: 15-Year Experience of 457 Patients in a Single Center in China. Front Endocrinol 2021; 12: 602221. https://doi.org/10.3389/fendo.2021.602221. 84 |
| [13] | Al-Saleh Y, AlSohaim A, AlAmoudi R, AlQarni A, Alenezi R, Mahdi L, et al. Primary hyperparathyroidism in Saudi Arabia revisited: a multi-centre observational study. BMC Endocr Disord 2022; 22: 155. https://doi.org/10.1186/s12902-022-01059-7. |
| [14] | Masi L. Primary Hyperparathyroidism. Front Horm Res 2019; 51: 1–12. https://doi.org/10.1159/000491034. |
| [15] | Greenspan BS, Dillehay G, Intenzo C, Lavely WC, O’Doherty M, Palestro CJ, et al. SNM Practice Guideline for Parathyroid Scintigraphy 4.0. J Nucl Med Technol 2012; 40: 111–8. https://doi.org/10.2967/jnmt.112.105122. |
| [16] | Gruson D. PTH and cardiovascular risk. Ann Endocrinol 2021; 82: 149–50. https://doi.org/10.1016/j.ando.2020.02.005. |
| [17] | Marques B, Martins R, Couto J, Santos J, Martins T, Rodrigues F. Primary hyperparathyroidism after thyroid surgery and autotransplantion of parathyroid gland. Endocr. Abstr., vol. 56, Bioscientifica; 2018. https://doi.org/10.1530/endoabs.56.P257. |
| [18] | Batista AF, Fontaínhas S, Pereira SC. Primary Hyperparathyroidism in a Post-total Thyroidectomy Patient: An Unexpected Diagnosis. Cureus n.d.; 15: e33308. https://doi.org/10.7759/cureus.33308. |
| [19] | Shirali AS, Wu S-Y, Chiang Y-J, Graham PH, Grubbs EG, Lee JE, et al. Recurrence after successful parathyroidectomy-Who should we worry about? Surgery 2022; 171: 40–6. https://doi.org/10.1016/j.surg.2021.06.035. |
| [20] | Mallick R, Nicholson KJ, Yip L, Carty SE, McCoy KL. Factors associated with late recurrence after parathyroidectomy for primary hyperparathyroidism. Surgery 2020; 167: 160–5. https://doi.org/10.1016/j.surg.2019.05.076. |
| [21] | Battistella E, Pomba L, Toniato R, Burei M, Gregianin M, Watutantrige Fernando S, et al. Evolution of the Diagnosis and Treatment of Primary Hyperparathyroidism. J Clin Med 2023; 12: 2057. https://doi.org/10.3390/jcm12052057. |
| [22] | Médecine du Maghreb électronique - Consultation des articles n.d. http://www.santetropicale.com/magelec/fr/visio_oa.asp?id_article=2344&o penaccess=ok (accessed September 14, 2023). 85. |
| [23] | Silverberg SJ, Shane E, Jacobs TP, Siris E, Bilezikian JP. A 10-Year Prospective Study of Primary Hyperparathyroidism with or without Parathyroid Surgery. N Engl J Med 1999; 341: 1249–55. https://doi.org/10.1056/NEJM199910213411701. |
| [24] | N. d. http://bibnum.ucad.sn/viewer.php?c=thm&d=thm%5f2015%5f0310 (accessed September 14, 2023). |
| [25] | Silverberg SJ, Clarke BL, Peacock M, Bandeira F, Boutroy S, Cusano NE, et al. Current Issues in the Presentation of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Fourth International Workshop. J Clin Endocrinol Metab 2014; 99: 3580–94. https://doi.org/10.1210/jc.2014- 1415. |
| [26] | Sung JY. Parathyroid ultrasonography: the evolving role of the radiologist. Ultrasonography 2015; 34: 268–74. https://doi.org/10.14366/usg.14071. |
| [27] | Saengsuda Y. The accuracy of 99m Tc-MIBI scintigraphy for preoperative parathyroid localization in primary and secondary-tertiary hyperparathyroidism. J Med Assoc Thail Chotmaihet Thangphaet 2012; 95 Suppl 3: S81-91. |
| [28] | Fujimoto N, Itoh K, Kishikawa H, Tohda A, Takaha N, Kobayashi Y, et al. [Preoperative localization of enlarged parathyroid glands by 99mTc-MIBI scintigraphy]. Nihon Hinyokika Gakkai Zasshi Jpn J Urol 1997; 88: 795–800. https://doi.org/10.5980/jpnjurol1989.88.795. |
| [29] | Ozouaki IE, Aschawa H, Guensi A. Apport de la scintigraphie parathyroïdienne dans la prise en charge des hyperparathyroïdies n.d. |
| [30] | Ghfir I, Ben Raïs N. Apport de la scintigraphie parathyroïdienne au 99mTc-MIBI en double phase dans l’exploration des hyperparathyroïdies. À propos de 20 cas. Médecine Nucl 2008; 32: 564–7. https://doi.org/10.1016/j.mednuc.2008.06.010. 86 |
| [31] | LeBlanc RA, Isaac A, Abele J, Biron VL, Côté DWJ, Hearn M, et al. Validation of a novel method for localization of parathyroid adenomas using SPECT/CT. J Otolaryngol - Head Neck Surg 2018; 47: 65. https://doi.org/10.1186/s40463-018-0307-6. |
| [32] | Hamidi S, Hedayat A, Esfahanian F, Kamalian N. Distribution of solitary parathyroid adenoma over the parathyroid glands and its surgical management. J Coll Physicians Surg--Pak JCPSP 2007; 17: 619–21. https://doi.org/10.2007/JCPSP.619621. |
| [33] | Limam K, Yeddes I, Meddeb I, Bennour S, Slim I, Mhiri A. Concordance de la PTH peropératoire et de la TEMP-TDM dans les adénomes parathyroïdiens. Ann Endocrinol 2018; 79: 313–4. https://doi.org/10.1016/j.ando.2018.06.356. |
| [34] | Papadakis M, Weyerbrock N, Zirngibl H, Dotzenrath C. Correlation of perioperative biochemical variables with single adenoma weight in patients with primary hyperparathyroidism. BMC Surg 2020; 20: 303. https://doi.org/10.1186/s12893-020-00922-5. |
| [35] | Rutledge R, Stiegel M, Thomas CG, Wild RE. The relation of serum calcium and immunoparathormone levels to parathyroid size and weight in primary hyperparathyroidism. Surgery 1985; 98: 1107–12. |
| [36] | Mózes G, Curlee KJ, Rowland CM, van Heerden JA, Thompson GB, Grant CS, et al. The predictive value of laboratory findings in patients with primary hyperparathyroidism. J Am Coll Surg 2002; 194: 126–30. https://doi.org/10.1016/s1072-7515(01)01139-5. |
| [37] | A. Dieye et al. Giant parathyroid adenoma complicated with hubgry bone syndrom. Journal of African clinical cases and reviews 2021; 5 (1): 79-83. |
| [38] | Tublin ME, Pryma DA, Yim JH, Ogilvie JB, Mountz JM, Bencherif B, et al. Localization of Parathyroid Adenomas by Sonography and Technetium Tc 99m Sestamibi Single-Photon Emission Computed Tomography Before Minimally Invasive Parathyroidectomy. J Ultrasound Med 2009; 28: 183–90. https://doi.org/10.7863/jum.2009.28.2.183. 87 |
| [39] | Ibrahim EAG, Elsadawy ME. Combined Tc-99m sesta MIBI scintigraphy and Ultrasonography in preoperative detection and localization of parathyroid adenoma. Egypt J Radiol Nucl Med 2015; 46: 937–41. https://doi.org/10.1016/j.ejrnm.2015.07.006. |
| [40] | Sukan A, Reyhan M, Aydin M, Yapar AF, Sert Y, Canpolat T, et al. Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging. Ann Nucl Med 2008; 22: 123–31. https://doi.org/10.1007/s12149-007-0086-z. |
| [41] | Haber RS, Kim CK, Inabnet WB. Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m) technetium sestamibi scintigraphy. Clin Endocrinol (Oxf) 2002; 57: 241–9. https://doi.org/10.1046/j.1365-2265.2002.01583.x. |
| [42] | Boudousq V, Guignard N, Gilly O, Chambert B, Mamou A, Moranne O, et al. Diagnostic Performance of Cervical Ultrasound, 99mTc-Sestamibi Scintigraphy, and Contrast-Enhanced 18F-Fluorocholine PET in Primary Hyperparathyroidism. J Nucl Med 2022; 63: 1081–6. https://doi.org/10.2967/jnumed.121.261900. |
| [43] | Araz M, Soydal Ç, Özkan E, Kir MK, İbiş E, Güllü S, et al. The efficacy of fluorine-18-choline PET/CT in comparison with 99mTc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism. Nucl Med Commun 2018; 39: 989–94. https://doi.org/10.1097/MNM.0000000000000899. |
APA Style
Bathily, E. H. A. L., Thiaw, G., Diop, O., Djigo, M. S., Gueye, K., et al. (2024). 99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar. European Journal of Biophysics, 12(1), 6-14. https://doi.org/10.11648/ejb.20241201.12
ACS Style
Bathily, E. H. A. L.; Thiaw, G.; Diop, O.; Djigo, M. S.; Gueye, K., et al. 99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar. Eur. J. Biophys. 2024, 12(1), 6-14. doi: 10.11648/ejb.20241201.12
AMA Style
Bathily EHAL, Thiaw G, Diop O, Djigo MS, Gueye K, et al. 99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar. Eur J Biophys. 2024;12(1):6-14. doi: 10.11648/ejb.20241201.12
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Download@article{10.11648/ejb.20241201.12,
author = {El Hadji Amadou Lamine Bathily and Gora Thiaw and Ousseynou Diop and Mamoudou Salif Djigo and Kalidou Gueye and Dioudé Diaw and Olatounde Herbert Fachinan and Mohamed Chekhma and Boucar Ndong and Omar Ndoye and Mamadou Mbodj},
title = {99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar},
journal = {European Journal of Biophysics},
volume = {12},
number = {1},
pages = {6-14},
doi = {10.11648/ejb.20241201.12},
url = {https://doi.org/10.11648/ejb.20241201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.ejb.20241201.12},
abstract = {Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99mTc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99mTc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate.
},
year = {2024}
}
TY - JOUR T1 - 99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar AU - El Hadji Amadou Lamine Bathily AU - Gora Thiaw AU - Ousseynou Diop AU - Mamoudou Salif Djigo AU - Kalidou Gueye AU - Dioudé Diaw AU - Olatounde Herbert Fachinan AU - Mohamed Chekhma AU - Boucar Ndong AU - Omar Ndoye AU - Mamadou Mbodj Y1 - 2024/02/05 PY - 2024 N1 - https://doi.org/10.11648/ejb.20241201.12 DO - 10.11648/ejb.20241201.12 T2 - European Journal of Biophysics JF - European Journal of Biophysics JO - European Journal of Biophysics SP - 6 EP - 14 PB - Science Publishing Group SN - 2329-1737 UR - https://doi.org/10.11648/ejb.20241201.12 AB - Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99mTc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99mTc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate. VL - 12 IS - 1 ER -
Nuclear Medicine Department, Idrissa Pouye General Hospital (HOGIP), Dakar, Senegal; Biophysical Laboratory, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University (UCAD), Dakar, Senegal
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