| Peer-Reviewed

Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update

Received: 10 May 2022     Accepted: 26 May 2022     Published: 31 May 2022
Views:       Downloads:
Abstract

The prevalence of gout in Japan has increased markedly since the 1960s. The westernization of the Japanese diet from 1955 is thought to be one factor the increase in the prevalence of gout. In Japan, most of gout patients are adults, and the number of gout patients are higher in men than in women. A previous report showed modification of dietary habits for the prevention of gout in Japanese people through the trends in micronutrient (vitamin and mineral) intake of Japanese people in 1946-2016. The aim of this article is to suggest what micronutrient intake is important for the prevention of gout in Japanese people in 2019 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2019) and the data of the National Health and Nutrition Survey in Japan (1946-2019) for the intake of micronutrients. Micronutrient intakes of Japanese people in 2019 was compared with those in 2016. The relationship between the number of gout patients and micronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2019 was higher compared to that in 2016 (2016: 1.105 million; 2019: 1.254 million). The daily intake of vitamin A, vitamin E, vitamin K, vitamin B1, vitamin B2, niacin, pantothenic acid, vitamin B6, folate, vitamin B12, vitamin C, sodium, salt, calcium, potassium, magnesium, phosphorus, iron, copper, and zinc of Japanese people in 2019 were higher compared to those in 2016, respectively. Whereas the daily vitamin D intake of Japanese people in 2019 was lower compared to that in 2016. The daily intake of vitamin A, vitamin D, vitamin B1, vitamin B2, vitamin B12, vitamin C, salt, calcium, iron, and copper were negatively correlated with the number of gout patients, respectively. Modification of micronutrient intake for the prevention of gout in Japanese people (especially adults) in 2019 is suggested as follows: limiting or decreasing salt intake; decreasing intake of phosphorus and copper; increase intake of vitamin A, vitamin E, vitamin B1, vitamin B6, folate, vitamin B12, calcium, potassium, magnesium, and zinc; increase intake of vitamin B2 and vitamin C in Japanese men (aged 20-59 years) and women (aged 20-59 years).

Published in American Journal of Health Research (Volume 10, Issue 3)
DOI 10.11648/j.ajhr.20221003.16
Page(s) 107-131
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Dietary Reference Intakes, Food, Gout, Hyperuricemia, Mineral, Uric Acid, Vitamin

References
[1] Kuo, C. F., Grainge, M. J., Zhang, W., & Doherty, M. (2015) Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol, 11, 649-662.
[2] Mikanagi, K. (1963) Gout in Japan. The Kyosai Medical Journal, 12, 14-37 (in Japanese).
[3] Nishioka, K., Mikanagi, K., & Hirose, K. (1974) Clinical study of gout and hyperuricemia: Epidemiology and pathogenesis. Rheum, 14, 95-105.
[4] Xia, Y., Wu, Q., Wang, H., Zhang, S., Jiang, Y., Gong, T., Xu, X., Chang, Q., Niu, K., & Zhao, Y. (2020) Global, regional and national burden of gout:, 1990-2017: a systematic analysis of the Global Burden of Disease Study. Rheumatology (Oxford), 59, 1529-1538.
[5] Koguchi, T. (2021) Modification of dietary habits for prevention of gout in Japanese people: Gout and the Japanese diet. Am J Health Res, 9, 117-127.
[6] Ministry of Health, Labour and Welfare. Household Statistics Office. (2020) Comprehensive Survey of Living Conditions [Internet]. Available from: https://www.mhlw.go.jp/toukei/list/20-21kekka.html.
[7] The Ministry of Health, Labour and Welfare. Household Statistics Office. (2021) Comprehensive Survey of Living Conditions [Internet]. Available from: https://www.e-stat.go.jp/stat-search/files?page=1&layout=datalist&toukei=00450061&tstat=000001141126&cycle=7&tclass1=000001141142&tclass2=000001142126&stat_infid=000031964417&tclass3val=0
[8] The Ministry of Health, Labour and Welfare. Household Statistics Office. (2021) Comprehensive Survey of Living Conditions [Internet]. Available from: https://www.e-stat.go.jp/dbview?sid=0003223900
[9] The Ministry of Health, Labour and Welfare. Health Service Bureau. (2020) National Health and Nutrition Survey Japan, 1946-2017 [Internet]. Available from: https://www.mhlw.go.jp/bunya/kenkou/kenkou_eiyou_chousa.html.
[10] The Ministry of Health, Labour and Welfare, Japan. (2020) Dietary Reference Intakes for Japanese, 2020 [Internet]. Available from: https://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/Overview.pdf.
[11] National Institute of Health and Nutrition [Internet]. Available from: www.nibiohn.go.jp/eiken/kenkounippon21/eiyouchousa/keinen_henka_time.html.
[12] Koguchi, T. (2022) Modification of macronutrient intake for prevention of gout in Japanese people in 2019: 2022 update. Am J Health Res, 10,
[13] Koguchi, T. (2021) Modification of dietary habits for prevention of gout in Japanese people: Gout and micronutrient intake or alcohol consumption. Am J Health Res, 9, 143-157.
[14] Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. (2021) Washington, D. C. The National Academy Press. [Internet]. Available from: https://www.nap.edu/catalog/11537.html
[15] The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. (2020) Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources [Internet]. Available from: https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf.
[16] U.S. Department of Health & Human Services. National Institutes of Health. Office of Dietary Supplements. Dietary Supplement Fact Sheets (nih.gov) [Internet]. Available from: https://ods.od.nih.gov/factsheets/list-all/
[17] Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. (2011) Washington, DC. The National Academy Press.
[18] Zhang, Y-Y., Qu, H-B., & Tian, J-W. (2020) Association between vitamin D and hyperuricemia among adults in the United States. Front Nutr, 7, 592777. Doi: 10.3389/fnut.2020. 592777.
[19] Emilion, E., & Emilion, R. (2011) Estimation of the 25 (OH) Vitamin D threshold below which secondary hyperparathyroidism may occur among African Migrant Women in Paris. Int J Vitam Nutr Res, 81, 218-224.
[20] Dalbeth, N., Horne, A., Gamble, G. D., Ames, R., & Reid, I. R. (2009) The effect of calcium supplementation on serum urate; analysis of a randomized controlled trial. Rheumatology, 48, 195-197.
[21] Hui, J. Y., Choi, J. W., Mount, D. B., Zhu, Y., Zhang, Y., & Choi, H. K. (2012) The independent association between parathyroid hormone levels and hyperuricemia: a national population study. Arthritis Res Ther, 14, R56.
[22] Isnuwardana, R., Bijukchhe, S., Thadanipon, K., Ingsathit, A. & Thakkinstian, A. (2020) Association between vitamin D and uric acid in adults: A systematic review and meta-analysis. Horm Metab Res, 52, 732-741.
[23] Charoenngam, N. (2021) Vitamin D and rheumatic diseases: A review of clinical evidence. Int J Mol Sci, 22, 10659.
[24] Ponvilawan, B., & Charoenngam, N. (2021) Vitamin D and uric acid: Is parathyroid hormone the missing link? J Clin Transl Endocrinol, 25, 100263.
[25] Chen, Y., Ma, H., Du, Y., Dong, J., Jin, C., Tan, L., & Wei, R. (2021) Functions of 1,25-dihydroxy vitamin D3, vitamin D3 receptor and interleukin-22 involved in pathogenesis of gout arthritis through altering metabolic pattern and inflammatory responses. PeerJ, 9, e12585.
[26] Luo, G., Yi, T., Zhang, G., Guo, X., & Jiang, X. (2017) Increased circulating Th22 cells in patients with gouty arthritis: A CONSORT-compliant article. Medicine, 96, e8329.
[27] Mohd Fahami, N. A., Ibrahim, I. A., Kamisah, Y., & Mohd Ismail, N. (2012) Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress. BMC Gastroenterol, 12, 54.
[28] Seifi, B., Kadkhodace, M., & Zahmatkesh, M. (2011) Effect of vitamin E therapy on serum uric acid in DOCA-salt-treated rats. Acta Physiol Hung, 98, 214-220.
[29] Zhang, L., Shi, X., Yu, J., Zhang, P., Ma, P., & Sun, Y. (2020) Dietary vitamin E intake was inversely associated with hyperuricemia in US adults: NHANES 2009-2014. Ann Nutr Metab, 76, 354-360.
[30] Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., & White, S. L. (2015) Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J, 14, 49.
[31] Zhang, Y. & Qiu, H. (2018) Folate, vitamin B6 and vitamin B12 intake in relation to hyperuricemia. J Clin Med, 7, 210.
[32] Lyu, L. C., Hsu, C. Y., Yeh, C. Y., Lee, M. S., Huang, S. H., & Chen, C. L. (2003) A case-control study of the association of diet and obesity with gout in Taiwan. Am J Clin Nutr, 78, 690-701.
[33] Mitch, W. E., Johnson, M. W., Kirshenbaum, J. M., & Lopez, R. E. (1981) Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects. Clin Pharmacol Ther, 29, 318-321.
[34] Sutton, J. L., Basu, T. K., & Dickerson, J. W. (1983) Effect of large doses of ascorbic acid in man on some nitrogenous components of urine. Hum Nutr Appl Nutr, 37, 136-140.
[35] Stein, H. B., Hasan, A., & Fox, I. H. (1976) Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy. Ann Intern Med, 84, 385-388.
[36] Huang, H. Y., Appel, L. J., Choi, M. J., Gelber, A. C., Charleston, J., Norkus, E. P., & Miller, E. R. 3 rd. (2005) The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial. Arthritis Rheum, 52, 1843-1847.
[37] Juraschek, S. P., Miller, E. R. 3rd., & Gelber, A. C. (2011) Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials. Arthritis Rheum, 63, 1295-1306.
[38] Zhang, Z., Harman, J. L., Coresh, J., Köttgen, A., McAdams-DeMarco, M. A., Correa, A., Young, B. A., Katz, R., & Rebholz, C. M. (2018) The dietary fructose: vitamin C intake ratio is associated with hyperuricemia in African-American adults. J Nutr, 148, 419-426.
[39] Beydoun, M. A., Fanelli-Kuczmarski, M. T., Canas, J-A., Beydoun, H. A., Evans, M. K., & Zonderman, A. B. (2018) Dietary factors are associated with serum uric acid trajectory differentially by race among urban adults. Br J Nutr, 120, 935-945.
[40] So, M. W., Lim, D-H., Kim, S-H., & Lee, S. (2020) Dietary and nutritional factors associated with hyperuricemia: The seventh Korean National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr, 29, 609-617.
[41] Gao, X., Curhan, G., Forman, J. P., Ascherio, A., & Choi, H. K. (2008) Vitamin C intake and serum uric acid concentration in men. J Rheumatol, 35, 1853-1858.
[42] Yu, K-H., See, L-C., Huang, Y-C., Yang, C-H., & Sun, J-H. (2008) Dietary factors associated with hyperuricemia in adults. Semin Arthritis Rheum, 37, 243-250.
[43] Doherty, M. (2009) New insights into epidemiology of gout. Rheumatology (Oxford), 48 (suppl 2), ii2-ii8.
[44] Torralba, K. D., De Jesus, E., & Rachabattula, S. (2012) The interplay between diet, urate transporters and the risk for gout and hyperuricemia: current and future directions. Int J Rheum Dis, 15, 499-506.
[45] Choi, H. K., Gao, X., & Curhan, G. (2009) Vitamin C intake and the risk of gout in men: A prospective study. Arch Intern Med, 169, 502-507.
[46] Enomoto, A., Kimura, H., Chairoungdua, A., Shigeta, Y., Jutabha, P., Cha, S. H., Hosoyamada, M., Takeda, M., Sekine, T., & Igarashi, T. (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature, 417, 447-452.
[47] Hayden, M. R., & Tyagi, S. C. (2004) Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond), 1, 10.
[48] Kim, S.-K., Choe, J.-Y., & Park, K.-Y. (2018) TXNIP -mediated nuclear factor-ĸB signaling pathway and intracellular shuttling of TXNIP in uric acid-induced NLRP3 inflammasome. Biochem Biophys Res Commun, 511, 725-731.
[49] Brzezińska, O., Styrzyński, F., Makowska, J., & Walczak, K. (2021) The role of vitamin C in prophylaxis and treatment of gout- A literature review. Nutrients, 13, 701.
[50] Stamp, L. K., O’Donnell, J. L., Frampton, C., Drake, J. M., Zhang, M., & Chapman, P. T. (2013) Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout. Arthritis Rheum, 65, 1636-1642.
[51] Institute of Medicine. National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Food and Nutrition Board; Committee to review the Dietary Reference Intakes for Sodium and Potassium. (2019) Washington, DC. The National Academy Press.
[52] Khanna, D., Fitzgerald, J. D., Khanna, P. P., Bae, S., Singh, M. K., Neogi, T., Pillinger, M. H., Merill, J., Lee, S., Prakash, S., Kaldas, M., Gogia, M., Perez-Ruiz, F., Taylor, W., Lioté, F., Choi, H., Singh, J. A., Dalbeth, N., Kaplan, S., Niyyar, V., Jones, D., Yarows, S. A., Roessler, B., Kerr, G., King, C., Levy, G., Furst, D. E., Edwards, N. L., Mandell, B., Schumacher, H. R., Robbins, M., Wenger, N., & Terkeltaub, R. (2012) 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Research, 64, 1431-1446.
[53] Cheng, W-W., Zhu, Q., & Zhang, H-Y. (2019) Mineral nutrition and the risk of chronic diseases: A mendelian randomization study. Nutrients, 11, 378.
[54] Zgaga, L., Theodoratou, E., Kyle, J., Farrington, S. M., Agakov, F., Tenesa, A., Walker, M., McNeill, G., Wright, A. F., Rudan, I., Dunlop, M. G., & Campbell, H. (2012) The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLoS One, 7, e38123.
[55] Wang, Y. L., Zeng, C., Wei, J., Yang, T., Li, H., Deng, Z. H., Yang, Y., Zhang, Y., Ding, X., Xie, D. X., Yang, T. B., & Lei, G. H. (2015) Association between dietary magnesium intake and hyperuricemia. PLoS One, 10, e0141079.
[56] Zhang, Y., & Qiu, H. (2018) Dietary magnesium intake and hyperuricemia among US adults. Nutrients, 10. 296.
[57] Dibaba, D. T., Xun, P., & He, K. (2014) Dietary magnesium intake is inversely associated with serum C-reactive protein levels: Meta-analysis and systematic review. Eur J Clin Nutr, 68, 510-516.
[58] Ruggiero, C., Cherubini, A., Ble, A., Bos, A. J., Maggio, M., Dixit, V. D., Lauretani, F., Bandinelli, S., Senin, U., & Ferrucci, L. (2006) Uric acid and inflammatory markers. Eur Heart J, 27, 1174-1181.
[59] Xie, D-X., Xiong, Y-L., Zeng, C., Wei, J., Yang, T., Li, H., Wang, Y-L., Gao, S-G., Li, Y-S., & Lei, G-H. (2015) Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study. BMJ Open, 5, e008637.
Cite This Article
  • APA Style

    Takashi Koguchi. (2022). Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update. American Journal of Health Research, 10(3), 107-131. https://doi.org/10.11648/j.ajhr.20221003.16

    Copy | Download

    ACS Style

    Takashi Koguchi. Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update. Am. J. Health Res. 2022, 10(3), 107-131. doi: 10.11648/j.ajhr.20221003.16

    Copy | Download

    AMA Style

    Takashi Koguchi. Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update. Am J Health Res. 2022;10(3):107-131. doi: 10.11648/j.ajhr.20221003.16

    Copy | Download

  • @article{10.11648/j.ajhr.20221003.16,
      author = {Takashi Koguchi},
      title = {Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update},
      journal = {American Journal of Health Research},
      volume = {10},
      number = {3},
      pages = {107-131},
      doi = {10.11648/j.ajhr.20221003.16},
      url = {https://doi.org/10.11648/j.ajhr.20221003.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20221003.16},
      abstract = {The prevalence of gout in Japan has increased markedly since the 1960s. The westernization of the Japanese diet from 1955 is thought to be one factor the increase in the prevalence of gout. In Japan, most of gout patients are adults, and the number of gout patients are higher in men than in women. A previous report showed modification of dietary habits for the prevention of gout in Japanese people through the trends in micronutrient (vitamin and mineral) intake of Japanese people in 1946-2016. The aim of this article is to suggest what micronutrient intake is important for the prevention of gout in Japanese people in 2019 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2019) and the data of the National Health and Nutrition Survey in Japan (1946-2019) for the intake of micronutrients. Micronutrient intakes of Japanese people in 2019 was compared with those in 2016. The relationship between the number of gout patients and micronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2019 was higher compared to that in 2016 (2016: 1.105 million; 2019: 1.254 million). The daily intake of vitamin A, vitamin E, vitamin K, vitamin B1, vitamin B2, niacin, pantothenic acid, vitamin B6, folate, vitamin B12, vitamin C, sodium, salt, calcium, potassium, magnesium, phosphorus, iron, copper, and zinc of Japanese people in 2019 were higher compared to those in 2016, respectively. Whereas the daily vitamin D intake of Japanese people in 2019 was lower compared to that in 2016. The daily intake of vitamin A, vitamin D, vitamin B1, vitamin B2, vitamin B12, vitamin C, salt, calcium, iron, and copper were negatively correlated with the number of gout patients, respectively. Modification of micronutrient intake for the prevention of gout in Japanese people (especially adults) in 2019 is suggested as follows: limiting or decreasing salt intake; decreasing intake of phosphorus and copper; increase intake of vitamin A, vitamin E, vitamin B1, vitamin B6, folate, vitamin B12, calcium, potassium, magnesium, and zinc; increase intake of vitamin B2 and vitamin C in Japanese men (aged 20-59 years) and women (aged 20-59 years).},
     year = {2022}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Modification of Micronutrient Intake for Prevention of Gout in Japanese People in 2019: 2022 Update
    AU  - Takashi Koguchi
    Y1  - 2022/05/31
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajhr.20221003.16
    DO  - 10.11648/j.ajhr.20221003.16
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 107
    EP  - 131
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20221003.16
    AB  - The prevalence of gout in Japan has increased markedly since the 1960s. The westernization of the Japanese diet from 1955 is thought to be one factor the increase in the prevalence of gout. In Japan, most of gout patients are adults, and the number of gout patients are higher in men than in women. A previous report showed modification of dietary habits for the prevention of gout in Japanese people through the trends in micronutrient (vitamin and mineral) intake of Japanese people in 1946-2016. The aim of this article is to suggest what micronutrient intake is important for the prevention of gout in Japanese people in 2019 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2019) and the data of the National Health and Nutrition Survey in Japan (1946-2019) for the intake of micronutrients. Micronutrient intakes of Japanese people in 2019 was compared with those in 2016. The relationship between the number of gout patients and micronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2019 was higher compared to that in 2016 (2016: 1.105 million; 2019: 1.254 million). The daily intake of vitamin A, vitamin E, vitamin K, vitamin B1, vitamin B2, niacin, pantothenic acid, vitamin B6, folate, vitamin B12, vitamin C, sodium, salt, calcium, potassium, magnesium, phosphorus, iron, copper, and zinc of Japanese people in 2019 were higher compared to those in 2016, respectively. Whereas the daily vitamin D intake of Japanese people in 2019 was lower compared to that in 2016. The daily intake of vitamin A, vitamin D, vitamin B1, vitamin B2, vitamin B12, vitamin C, salt, calcium, iron, and copper were negatively correlated with the number of gout patients, respectively. Modification of micronutrient intake for the prevention of gout in Japanese people (especially adults) in 2019 is suggested as follows: limiting or decreasing salt intake; decreasing intake of phosphorus and copper; increase intake of vitamin A, vitamin E, vitamin B1, vitamin B6, folate, vitamin B12, calcium, potassium, magnesium, and zinc; increase intake of vitamin B2 and vitamin C in Japanese men (aged 20-59 years) and women (aged 20-59 years).
    VL  - 10
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • Department of Human Education, Kokugakuin Tochigi Junior College, Tochigi, Japan

  • Sections