American Journal of Life Sciences

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Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile

Received: 12 December 2014    Accepted: 22 December 2014    Published: 20 January 2015
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Abstract

In this investigation we included an extraction of Borassusflabilifer root and reported to have beneficial effect in lowering of blood pressure and treatment of hypertensive patients. Borassusflabilifer root were collected from various part of Noakhali and extract was prepared by following standard method. The present study was conducted to determine the in vivo effect of Borassusflabilifer root extract on tissues and serum lipids in experimental rats. 15 male Wistar rats were randomly divided into 3 groups and administered different doses of the extract for 30 days while control group received distilled water. Lipid profile in the serum, liver, kidney and heart of the experimental animals were measured and compared with the control. Borassusflabilifer caused significant (p<0.0) reduction in serum total cholesterol and LDL cholesterol in a dose dependent manner in rats while serum HDL cholesterol was significantly elevated. Serum triglyceride level was not significantly affected. There was also a significant increase in the levels of total cholesterol and triglyceride in the liver while lipid profile in the heart and Kidney were unaffected. This result suggests positive alterations in lipid metabolism and storage in rats which corroborate the efficacy of Borassusflabilifer root extract in the management of atherosclerosis caused by lipid abnormalities. We can develop techniques on rational design of drug for the treatment of heart diseases and further study can lead to the development of a therapy for other diseases like diabetes.

DOI 10.11648/j.ajls.20150301.12
Published in American Journal of Life Sciences (Volume 3, Issue 1, February 2015)
Page(s) 6-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hypertension, HDL, LDL, Triglyceride, Atherosclerosis, Rational Design

References
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[6] Dulger B., Celikler S., Kirmizi S., 1998. Antimicrobial activity of hyper Perforratum(L). KUKEM Dergisi, 21: 33-40, Ahmed I., Beg A. Z., 2001. Antimicrobial and phytochemical Studies on 45 Indian medicinal plants againist multi-drug resistant human pathogens. J. Enthopharmacpl., 74:113-123, Lopez A., Hudson J. B., Towers G. H. N., 2001. Antimicrobial activities of Colombian medicinal plants. J. Ethnopharmacol., 77: 189-196.
[7] Vermani K., Grag S., 2002. Herbal medicines for sexually transmitted diseases and AIDS. J. Ethanopharmacol., 80: 49-66.
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  • APA Style

    Rajib Dab Nath, Md. Sohel Rana, Md. Areeful Haque, Pobittro Sen, Md. Elias Mehedy, et al. (2015). Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile. American Journal of Life Sciences, 3(1), 6-10. https://doi.org/10.11648/j.ajls.20150301.12

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    ACS Style

    Rajib Dab Nath; Md. Sohel Rana; Md. Areeful Haque; Pobittro Sen; Md. Elias Mehedy, et al. Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile. Am. J. Life Sci. 2015, 3(1), 6-10. doi: 10.11648/j.ajls.20150301.12

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    AMA Style

    Rajib Dab Nath, Md. Sohel Rana, Md. Areeful Haque, Pobittro Sen, Md. Elias Mehedy, et al. Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile. Am J Life Sci. 2015;3(1):6-10. doi: 10.11648/j.ajls.20150301.12

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  • @article{10.11648/j.ajls.20150301.12,
      author = {Rajib Dab Nath and Md. Sohel Rana and Md. Areeful Haque and Pobittro Sen and Md. Elias Mehedy and Mrityunjoy Biswas},
      title = {Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1},
      pages = {6-10},
      doi = {10.11648/j.ajls.20150301.12},
      url = {https://doi.org/10.11648/j.ajls.20150301.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.12},
      abstract = {In this investigation we included an extraction of Borassusflabilifer root and reported to have beneficial effect in lowering of blood pressure and treatment of hypertensive patients. Borassusflabilifer root were collected from various part of Noakhali and extract was prepared by following standard method. The present study was conducted to determine the in vivo effect of Borassusflabilifer root extract on tissues and serum lipids in experimental rats. 15 male Wistar rats were randomly divided into 3 groups and administered different doses of the extract for 30 days while control group received distilled water. Lipid profile in the serum, liver, kidney and heart of the experimental animals were measured and compared with the control. Borassusflabilifer caused significant (p<0.0) reduction in serum total cholesterol and LDL cholesterol in a dose dependent manner in rats while serum HDL cholesterol was significantly elevated. Serum triglyceride level was not significantly affected. There was also a significant increase in the levels of total cholesterol and triglyceride in the liver while lipid profile in the heart and Kidney were unaffected. This result suggests positive alterations in lipid metabolism and storage in rats which corroborate the efficacy of Borassusflabilifer root extract in the management of atherosclerosis caused by lipid abnormalities. We can develop techniques on rational design of drug for the treatment of heart diseases and further study can lead to the development of a therapy for other diseases like diabetes.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Extraction of Borassus Flabilifer Root and Biochemical Effects on Experimental Mouse Model- Lipid Profile
    AU  - Rajib Dab Nath
    AU  - Md. Sohel Rana
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    AU  - Pobittro Sen
    AU  - Md. Elias Mehedy
    AU  - Mrityunjoy Biswas
    Y1  - 2015/01/20
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    DO  - 10.11648/j.ajls.20150301.12
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 6
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150301.12
    AB  - In this investigation we included an extraction of Borassusflabilifer root and reported to have beneficial effect in lowering of blood pressure and treatment of hypertensive patients. Borassusflabilifer root were collected from various part of Noakhali and extract was prepared by following standard method. The present study was conducted to determine the in vivo effect of Borassusflabilifer root extract on tissues and serum lipids in experimental rats. 15 male Wistar rats were randomly divided into 3 groups and administered different doses of the extract for 30 days while control group received distilled water. Lipid profile in the serum, liver, kidney and heart of the experimental animals were measured and compared with the control. Borassusflabilifer caused significant (p<0.0) reduction in serum total cholesterol and LDL cholesterol in a dose dependent manner in rats while serum HDL cholesterol was significantly elevated. Serum triglyceride level was not significantly affected. There was also a significant increase in the levels of total cholesterol and triglyceride in the liver while lipid profile in the heart and Kidney were unaffected. This result suggests positive alterations in lipid metabolism and storage in rats which corroborate the efficacy of Borassusflabilifer root extract in the management of atherosclerosis caused by lipid abnormalities. We can develop techniques on rational design of drug for the treatment of heart diseases and further study can lead to the development of a therapy for other diseases like diabetes.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Pharmacy, Noakhali Science & Technology University, Noakhali, Bangladesh

  • Department of Pharmacy, Jahangirnagar University, Dhaka, Bangladesh

  • Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, Stamford University, Dhaka, Bangladesh

  • Department of Microbiology, University of Chittagong, Chittagong, Bangladesh

  • Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh

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