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The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012

Received: Jan. 18, 2014    Accepted:     Published: Mar. 20, 2014
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Abstract

Introduction: Fibrocystic changes are considered as common and benign changes in the breast tissue. This study aimed to determine the prevalence of pathologic changes Including fibrocystic changes, hyperplasia, and carcinoma in breast tissue specimens of patients underwent reduction Mammoplasty.Methods: 128 consecutive patients over a period of 5 years from 2007 to 2012, who were admitted at the Rasool-Akram, Firoozgar, and Sadr Hospitals for reduction mammoplasty, were investigated in this study. In all patients an average of 500 grams of breast tissue from each side during mammoplasty was sent for pathologic evaluation. The variables measured in the study included age, fibrocystic changes, and hyperplastic changes in the pathology specimens of these patients. Data analysis was performed using SPSS 18 software. Results: 71 patients (55.5%) had fibrocystic changes. 6 patients (4.7%) were reported to have hyperplasia. Carcinoma was not observed in any of the samples. The prevalence of fibrocystic changes increased with age. Hyperplastic changes were not associated with age and with fibrocystic changes. But it was the most common in the ages between 31 and 40 years. Conclusion: Fibrocystic breast changes are common, and their prevalence increases with age. However, they are not associated with hyperplasia and cancer risk.

DOI 10.11648/j.ass.20140201.12
Published in Advances in Surgical Sciences ( Volume 2, Issue 1, February 2014 )
Page(s) 5-8
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Breast Fibrocystic Changes, Pathology, Mammoplasty

References
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[2] Kabat GC, Jones JG, Olson N. A multi-center prospective cohort study ofbenign breast disease and risk of subsequent breast cancer. Cancer Causes Control2010; 21:821-828.
[3] Boschert MT, Barone CM, Puckett CL. Outcome analysis of reductionmammaplasty. PlastReconstr Surg. 1996;98:451-4.
[4] London SJ, Connolly JL, Schnitt SJ, Colditz GA. A prospectivestudy of benignbreast disease and the risk of breast cancer.JAMA 1992; 267:941-944.
[5] Cotran., Kumar., Collins Robbins Pathologic basis of disease, 6 thed b Philadelphia, Saunders company, 1999, PP: 1098-1100.
[6] Dotto J, Kluk M, Geramizadeh B, Tavassoli FA. Frequency of clinically occultintraepithelial and invasive neoplasia in reduction mammoplasty specimens: astudy of 516 cases. Int J SurgPathol. 2008 Jan;16(1):25-30.
[7] Samdanci ET, Firat C, Cakir E, Ak M, Sayin S, Nurkabul Z. The incidence ofnon-proliferative and precancerous lesions of reduction mammoplasty: evaluationof 273 cases. Eur Rev Med PharmacolSci 2011;15(10):1207-11.
[8] Ambaye AB, MacLennan SE, Goodwin AJ, Suppan T, Naud S, Weaver DL.Carcinoma and atypical hyperplasia in reduction mammaplasty: increasedsampling leads to increased detection. A prospective study.PlastReconstrSurg2009 Nov;124(5):1386-92.
[9] Clark CJ, Whang S, Paige KT. Incidence of precancerous lesions in breastreduction tissue: a pathologic review of 562 consecutive patients. PlastReconstrSurg 2009;124(4):1033-9.
[10] Ayhan S, Başterzi Y, Yavuzer R, Latifoğlu O, Cenetoğlu S, Atabay K, et al.Histologic profiles of breast reduction specimens. Aesthetic PlastSurg 2002;26(3):203-5.
[11] Kyriopoulos E, Kakagia D, Zapandioti P, Papaliodi E, Tsoutsos D. Pathologicfindings in breast reduction specimens: detection of occult premalignant andcancerous lesions. Onkologie. 2012;35(10):583-6.
[12] Pitanguy I, Torres E, Salgado F, PiresViana GA. Breast pathology and reduction mammaplasty. PlastReconstr Surg. 2005 Mar;115(3):729-34; discussion735.
[13] Blansfield JA, Kukora JS, Goldhahn RT Jr, Buinewicz BR. Suspicious findingsin reduction mammaplasty specimens: review of 182 consecutive patients. AnnPlast Surg. 2004 Feb;52(2):126-30.
[14] Viana GA, Pitanguy I, Torres E. Histopathological findings in surgicalspecimens obtained from reduction mammaplasties. Breast. 2005 Jun;14(3):242-8
[15] http://www.mckinley.illinois.edu/handouts/breast_health/breast_health.html
[16] Berek and Novaks, Gynecology, 14th edition, 2007, pages 637-659.
[17] Up To Date, 2012
[18] Stenchever, Morton A., Droegemuller, William, Herbst, Arthur, Mishell, Daniel R., Comprehensive Gynecology, 54th Edition; Mosby 2007, pages 327-357.
[19] Benign Breast Disease and Breast Cancer Tutorial; Dr. William H. Goldberg, University of Wisconsin
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    Mostafa Hosseini, Adnan Tizmaghz, Hamidreza Alizadeh Otaghvar, Marjan Shams. (2014). The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012. Advances in Surgical Sciences, 2(1), 5-8. https://doi.org/10.11648/j.ass.20140201.12

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    Mostafa Hosseini; Adnan Tizmaghz; Hamidreza Alizadeh Otaghvar; Marjan Shams. The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012. Adv. Surg. Sci. 2014, 2(1), 5-8. doi: 10.11648/j.ass.20140201.12

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    AMA Style

    Mostafa Hosseini, Adnan Tizmaghz, Hamidreza Alizadeh Otaghvar, Marjan Shams. The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012. Adv Surg Sci. 2014;2(1):5-8. doi: 10.11648/j.ass.20140201.12

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  • @article{10.11648/j.ass.20140201.12,
      author = {Mostafa Hosseini and Adnan Tizmaghz and Hamidreza Alizadeh Otaghvar and Marjan Shams},
      title = {The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012},
      journal = {Advances in Surgical Sciences},
      volume = {2},
      number = {1},
      pages = {5-8},
      doi = {10.11648/j.ass.20140201.12},
      url = {https://doi.org/10.11648/j.ass.20140201.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ass.20140201.12},
      abstract = {Introduction: Fibrocystic changes are considered as common and benign changes in the breast tissue. This study aimed to determine the prevalence of pathologic changes Including fibrocystic changes, hyperplasia, and carcinoma in breast tissue specimens of patients underwent reduction Mammoplasty.Methods: 128 consecutive patients over a period of 5 years from 2007 to 2012, who were admitted at the Rasool-Akram, Firoozgar, and Sadr Hospitals for reduction mammoplasty, were investigated in this study. In all patients an average of 500 grams of breast tissue from each side during mammoplasty was sent for pathologic evaluation. The variables measured in the study included age, fibrocystic changes, and hyperplastic changes in the pathology specimens of these patients. Data analysis was performed using SPSS 18 software. Results: 71 patients (55.5%) had fibrocystic changes. 6 patients (4.7%) were reported to have hyperplasia. Carcinoma was not observed in any of the samples. The prevalence of fibrocystic changes increased with age. Hyperplastic changes were not associated with age and with fibrocystic changes. But it was the most common in the ages between 31 and 40 years. Conclusion: Fibrocystic breast changes are common, and their prevalence increases with age. However, they are not associated with hyperplasia and cancer risk.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - The Prevalence of Fibrocystic Changes of Breast Tissue of Patients who Underwent Reduction Mammoplasty in Rasool-Akram, Firuzgar and Sadr Hospitals during 2007-2012
    AU  - Mostafa Hosseini
    AU  - Adnan Tizmaghz
    AU  - Hamidreza Alizadeh Otaghvar
    AU  - Marjan Shams
    Y1  - 2014/03/20
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    N1  - https://doi.org/10.11648/j.ass.20140201.12
    DO  - 10.11648/j.ass.20140201.12
    T2  - Advances in Surgical Sciences
    JF  - Advances in Surgical Sciences
    JO  - Advances in Surgical Sciences
    SP  - 5
    EP  - 8
    PB  - Science Publishing Group
    SN  - 2376-6182
    UR  - https://doi.org/10.11648/j.ass.20140201.12
    AB  - Introduction: Fibrocystic changes are considered as common and benign changes in the breast tissue. This study aimed to determine the prevalence of pathologic changes Including fibrocystic changes, hyperplasia, and carcinoma in breast tissue specimens of patients underwent reduction Mammoplasty.Methods: 128 consecutive patients over a period of 5 years from 2007 to 2012, who were admitted at the Rasool-Akram, Firoozgar, and Sadr Hospitals for reduction mammoplasty, were investigated in this study. In all patients an average of 500 grams of breast tissue from each side during mammoplasty was sent for pathologic evaluation. The variables measured in the study included age, fibrocystic changes, and hyperplastic changes in the pathology specimens of these patients. Data analysis was performed using SPSS 18 software. Results: 71 patients (55.5%) had fibrocystic changes. 6 patients (4.7%) were reported to have hyperplasia. Carcinoma was not observed in any of the samples. The prevalence of fibrocystic changes increased with age. Hyperplastic changes were not associated with age and with fibrocystic changes. But it was the most common in the ages between 31 and 40 years. Conclusion: Fibrocystic breast changes are common, and their prevalence increases with age. However, they are not associated with hyperplasia and cancer risk.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Surgical department of Iran University of medical science, Tehran, Iran

  • Surgical department of Iran University of medical science, Tehran, Iran

  • Surgical department of Iran University of medical science, Tehran, Iran

  • Surgical department of Iran University of medical science, Tehran, Iran

  • Section