Aging is a complex biological process influenced not only by genetic predispositions but also significantly shaped by environmental factors. This review synthesizes experimental evidence from model systems elucidating how environmental exposures modulate genetic aging processes. Studies in organisms such as Caenorhabditis elegans, mice, and human cellular models demonstrate that external conditions including diet, psychosocial stress, pollutants, and physical activity interact dynamically with genetic and epigenetic regulators to influence lifespan and healthspan. Advances in molecular biology and omics technologies reveal mechanisms such as DNA methylation alterations, histone modifications, telomere attrition, oxidative stress, and cellular senescence as critical mediators of gene-environment crosstalk in aging. Genetic manipulation tools like CRISPR and RNA interference enable precise interrogation of genes implicated in environmental responses, deepening understanding of aging pathways. While model organisms provide invaluable platforms to dissect these interactions, challenges remain in translating findings to human aging due to complexity and heterogeneity. Future directions highlight emerging single-cell multiomics, organ-on-chip systems, and artificial intelligence integration to unravel aging's multifactorial nature. The review underscores the necessity of multidisciplinary approaches combining genetics, environmental sciences, and computational biology to develop therapeutic strategies aimed at modulating environmental factors to promote healthy aging. These insights pave the way for personalized interventions targeting both genetic susceptibilities and modifiable environmental risks, ultimately advancing longevity and well-being.
| Published in | European Journal of Clinical and Biomedical Sciences (Volume 11, Issue 4) |
| DOI | 10.11648/j.ejcbs.20251104.12 |
| Page(s) | 49-59 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Epigenetic Modifications, Model Organisms, Aging Biomarkers, Genetic Manipulation, Environmental Exposures
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APA Style
Molla, A. (2025). Environmental Influences on Genetic Aging Processes: Experimental Evidence from Model Systems. European Journal of Clinical and Biomedical Sciences, 11(4), 49-59. https://doi.org/10.11648/j.ejcbs.20251104.12
ACS Style
Molla, A. Environmental Influences on Genetic Aging Processes: Experimental Evidence from Model Systems. Eur. J. Clin. Biomed. Sci. 2025, 11(4), 49-59. doi: 10.11648/j.ejcbs.20251104.12
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Download@article{10.11648/j.ejcbs.20251104.12,
author = {Alebachew Molla},
title = {Environmental Influences on Genetic Aging Processes: Experimental Evidence from Model Systems
},
journal = {European Journal of Clinical and Biomedical Sciences},
volume = {11},
number = {4},
pages = {49-59},
doi = {10.11648/j.ejcbs.20251104.12},
url = {https://doi.org/10.11648/j.ejcbs.20251104.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20251104.12},
abstract = {Aging is a complex biological process influenced not only by genetic predispositions but also significantly shaped by environmental factors. This review synthesizes experimental evidence from model systems elucidating how environmental exposures modulate genetic aging processes. Studies in organisms such as Caenorhabditis elegans, mice, and human cellular models demonstrate that external conditions including diet, psychosocial stress, pollutants, and physical activity interact dynamically with genetic and epigenetic regulators to influence lifespan and healthspan. Advances in molecular biology and omics technologies reveal mechanisms such as DNA methylation alterations, histone modifications, telomere attrition, oxidative stress, and cellular senescence as critical mediators of gene-environment crosstalk in aging. Genetic manipulation tools like CRISPR and RNA interference enable precise interrogation of genes implicated in environmental responses, deepening understanding of aging pathways. While model organisms provide invaluable platforms to dissect these interactions, challenges remain in translating findings to human aging due to complexity and heterogeneity. Future directions highlight emerging single-cell multiomics, organ-on-chip systems, and artificial intelligence integration to unravel aging's multifactorial nature. The review underscores the necessity of multidisciplinary approaches combining genetics, environmental sciences, and computational biology to develop therapeutic strategies aimed at modulating environmental factors to promote healthy aging. These insights pave the way for personalized interventions targeting both genetic susceptibilities and modifiable environmental risks, ultimately advancing longevity and well-being.
},
year = {2025}
}
TY - JOUR T1 - Environmental Influences on Genetic Aging Processes: Experimental Evidence from Model Systems AU - Alebachew Molla Y1 - 2025/10/31 PY - 2025 N1 - https://doi.org/10.11648/j.ejcbs.20251104.12 DO - 10.11648/j.ejcbs.20251104.12 T2 - European Journal of Clinical and Biomedical Sciences JF - European Journal of Clinical and Biomedical Sciences JO - European Journal of Clinical and Biomedical Sciences SP - 49 EP - 59 PB - Science Publishing Group SN - 2575-5005 UR - https://doi.org/10.11648/j.ejcbs.20251104.12 AB - Aging is a complex biological process influenced not only by genetic predispositions but also significantly shaped by environmental factors. This review synthesizes experimental evidence from model systems elucidating how environmental exposures modulate genetic aging processes. Studies in organisms such as Caenorhabditis elegans, mice, and human cellular models demonstrate that external conditions including diet, psychosocial stress, pollutants, and physical activity interact dynamically with genetic and epigenetic regulators to influence lifespan and healthspan. Advances in molecular biology and omics technologies reveal mechanisms such as DNA methylation alterations, histone modifications, telomere attrition, oxidative stress, and cellular senescence as critical mediators of gene-environment crosstalk in aging. Genetic manipulation tools like CRISPR and RNA interference enable precise interrogation of genes implicated in environmental responses, deepening understanding of aging pathways. While model organisms provide invaluable platforms to dissect these interactions, challenges remain in translating findings to human aging due to complexity and heterogeneity. Future directions highlight emerging single-cell multiomics, organ-on-chip systems, and artificial intelligence integration to unravel aging's multifactorial nature. The review underscores the necessity of multidisciplinary approaches combining genetics, environmental sciences, and computational biology to develop therapeutic strategies aimed at modulating environmental factors to promote healthy aging. These insights pave the way for personalized interventions targeting both genetic susceptibilities and modifiable environmental risks, ultimately advancing longevity and well-being. VL - 11 IS - 4 ER -
Department of Biotechnology, Wolaita Sodo University, Wolaita, Ethiopia
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