Introduction: Prostate cancer is a slow-growing hormone-dependent malignant tumor that can have negative impacts at short or long term. There are many treatment options for localized prostate cancer, but most of them are of limited access in sub-Saharan Africa. Open retropubic radical prostatectomy presents a challenge in terms of early diagnosis of prostate cancer. The aim of our study was to share our experience in the field and to report patient outcomes on short and medium term. Methodology: Our study was retrospective, covering all patients who underwent open retropubic radical prostatectomy in the urology departments of Yaounde Central Hospital, Douala General Hospital, and Catholic Hospital of the Love of Our Lady in Douala over a 10-year period (2013-2023). We studied the progression of the disease and quality of life after surgery. This assessment was mainly carried out using validated self-administered questionnaires, the ICIQ (International Consultation Incontinence Questionnaire) for urinary incontinence and the IIEF 5 (International Index of Erectile Function) for erectile dysfunction. Results: We selected five patients who had undergone Open Retropubic Radical Prostatectomy (ORRP). The average age was 62.8 years. Total PSA was the postoperative biologic follow-up parameter. One patient had received hormone therapy and salvage radiotherapy, while two others were in remission. In terms of lower urinary function, three patients had urinary incontinence (UI). All of these disorders were treated with appropriate perineal physiotherapy and an anticholinergic agent. In terms of erectile function, three patients had erectile dysfunction. Anastomotic site stenosis was found in three patients. Conclusion: Surgical treatment of localized prostate cancer allows for cancer control and, in some cases, sexual and urinary function impairment is observed. We were thus able to evaluate the short- and medium-term cancer and functional outcomes in patients who underwent ORRP in two cities in Cameroon.
| Published in | International Journal of Clinical Urology (Volume 9, Issue 2) |
| DOI | 10.11648/j.ijcu.20250902.30 |
| Page(s) | 219-225 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Prostate Cancer, Radical Prostatectomy, Retropubic, Cameroon
| [1] | Gandaglia G. Bray F. Cooperberg MR. Karnes RJ. Leveridge MJ. Moretti K. Murphy DG. Penson DF. Miller DC. Prostate Cancer Registries: Current Status and Future Directions. Eur Urol. 2016 June; 69(6): 998-1012. |
| [2] | Rawla P. Epidemiology of Prostate Cancer. World J Oncol. 2019 Apr; 10(2): 63-89. |
| [3] | Campbell MF, Wein AJ, Kavoussi LR. Campbell-Walsh urology. 9th ed. Philadelphia: W. B. Saunders; 2007. 3945 p. |
| [4] | Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917. |
| [5] |
Giona S. The Epidemiology of Prostate Cancer. In: Bott SRJ, Ng KL, editors. Prostate Cancer [Internet]. Brisbane (AU): Exon Publications; 2021 May 27. Chapter 1. Available from:
https://doi.org/10.36255/exonpublications.prostatecancer.epidemiology |
| [6] | Engbang JP, Sala B, Moby E, Ligan Y, Djimeli B, Simo G, Moune A, Mouelle AS, Fewou A, Essame JLO, Hasigov A. Epidemiomorphology of Prostate Cancer in Cameroon: About 1047 Cases. Journal of Cancer and Tumor International. 2017 Jan; 6(3): 1-8. |
| [7] | Mohamed Jalloh. Radical Prostatectomy Short Term Evaluation of 18 cases. African Journal of Cancer. 2009. |
| [8] | Christopher JD Wallis, Refik Saskin, Richard Choo, Prakesh S; Shash, Cyril Danjoux and Robert K. Nam. Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis. European Urology. July 2016; 70(1): 21-30. |
| [9] | Gueye SM, Zeigler-Johnson CM, Friebel T, Spangler E, Jalloh M, MacBride S, Malkowicz SB, Rebbeck TR. Clinical characteristics of prostate cancer in African Americans, American whites, and Senegalese men. Urology. 2003 May 6(15): 987-92. |
| [10] | Kalampokis N, Grivas N, Karavitakis M, Leotsakos I, Katafigiotis I, Mochovas MC, Van der Poel H. European Association of Urology Eau Young Academic Urologists Yau Robotic Urology Working Group. Nondetectable Prostate Carcinoma (pT0) after Radical Prostatectomy: A Narrative Review. Curr Oncol. 2022 Feb 23; 29(3): 1309-15. |
| [11] | Cao D, Hafez M, Berg K, Murphy K, Epstein JI. Little or no residual prostate cancer at radical prostatectomy: vanishing cancer or switched specimen? a microsatellite analysis of specimen identity. Am J Surg Pathol. 2005 Apr; 29(4): 467-73. |
| [12] | Bostwick DG, Bostwick KC. 'Vanishing' prostate cancer in radical prostatectomy specimens: incidence and long-term follow-up in 38 cases. BJU Int. 2004 Jul; 94(1): 57-8. |
| [13] | Abramowitz MC, Li T, Buyyounouski MK, Ross E, Uzzo RG, Pollack A, Horwitz EM. The Phoenix definition of biochemical failure predicts for overall survival in patients with prostate cancer. Cancer. 2008 Jan 1; 112(1): 55-60. |
| [14] |
Abugharib A, Jackson WC, Tumati V, Dess RT, Lee JY, Zhao SG, Soliman M, Zumsteg ZS, Mehra R, Feng FY, Morgan TM, Desai N, Spratt DE. Very Early Salvage Radiotherapy Improves Distant Metastasis-Free Survival. J Urol. 2017 Mar; 197(3 Pt 1): 662-668.
https://doi.org/10.1016/j.juro.2016.08.106 Epub 2016 Sep 7. |
| [15] | Tilki D, Chen M-H, Wu J, Huland H, Graefen M, Mohamad O, et al. Protate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death. J Clin Oncol. 2023 May 1; 41(13): 2428-35. |
| [16] | Shipley WU, Seiferheld W, Lukka HR, Major PP, Heney NM, Grignon DJ, Sartor O, Patel MP, Bahary JP, Zietman AL, Pisansky TM, Zeitzer KL, Lawton CA, Feng FY, Lovett RD, Balogh AG, Souhami L, Rosenthal SA, Kerlin KJ, Dignam JJ, Pugh SL, Sandler HM; NRG Oncology RTOG. Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer. N Engl J Med. 2017 Feb 2; 376(5): 417-428. |
| [17] |
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group. Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data. Lancet. 2020 Oct 31; 396(10260): 1422-1431.
https://doi.org/10.1016/S0140-6736(20)31952-8 Epub 2020 Sep 28. |
| [18] |
Parker CC, Clarke NW, Cook AD, Kynaston HG, Petersen PM, Catton C, Cross W, Logue J, Parulekar W, Payne H, Persad R, Pickering H, Saad F, Anderson J, Bahl A, Bottomley D, Brasso K, Chahal R, Cooke PW, Eddy B, Gibbs S, Goh C, Gujral S, Heath C, Henderson A, Jaganathan R, Jakobsen H, James ND, Kanaga Sundaram S, Lees K, Lester J, Lindberg H, Money-Kyrle J, Morris S, O'Sullivan J, Ostler P, Owen L, Patel P, Pope A, Popert R, Raman R, Røder MA, Sayers I, Simms M, Wilson J, Zarkar A, Parmar MKB, Sydes MR. Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial. Lancet. 2020 Oct 31; 396(10260): 1413-1421.
https://doi.org/10.1016/S0140-6736(20)31553-1 Epub 2020 Sep 28. |
| [19] | Saleh A, Abboudi H, Ghazal-Aswad M, Mayer EK, Vale JA. Management of erectile dysfunction post-radical prostatectomy. Res Rep Urol. 2015 Feb 23; 7: 19-33. |
| [20] | Bratu O, Oprea I, Marcu D, Spinu D, Niculae A, Geavlete B, Mischianu D. Erectile dysfunction post-radical prostatectomy - a challenge for both patient and physician. J Med Life. 2017 Jan-Mar; 10(1): 13-18. |
| [21] |
Bauer RM, Bastian PJ, Gozzi C, Stief CG. Postprostatectomy incontinence: all about diagnosis and management. Eur Urol. 2009 Feb; 55(2): 322-33.
https://doi.org/10.1016/j.eururo.2008.10.029 Epub 2008 Oct 23. |
| [22] | Park R, Martin S, Goldberg JD, Lepor H. Anastomotic strictures following radical prostatectomy: insights into incidence, effectiveness of intervention, effect on continence, and factors predisposing to occurrence. Urology. 2001 Apr; 57(4): 742-6. |
| [23] |
Lubahn JD, Zhao LC, Scott JF, Hudak SJ, Chee J, Terlecki R, Breyer B, Morey AF. Poor quality of life in patients with urethral stricture treated with intermittent self-dilation. J Urol. 2014 Jan; 191(1): 143-7.
https://doi.org/10.1016/j.juro.2013.06.054 Epub 2013 Jun 29. |
| [24] | Borboroglu PG, Sands JP, Roberts JL, Amling CL. Risk factors for vesicourethral anastomotic stricture after radical prostatectomy. Urology. 2000 Jul; 56(1): 96-100. |
APA Style
Guy, E. N. F., Barthelemy, M. M. J., Cedrick, F. J., Dorcas, W. M. P., Marcel, N. J., et al. (2025). Open Retropubic Radical Prostatectomy: Experience in Cameroon. International Journal of Clinical Urology, 9(2), 219-225. https://doi.org/10.11648/j.ijcu.20250902.30
ACS Style
Guy, E. N. F.; Barthelemy, M. M. J.; Cedrick, F. J.; Dorcas, W. M. P.; Marcel, N. J., et al. Open Retropubic Radical Prostatectomy: Experience in Cameroon. Int. J. Clin. Urol. 2025, 9(2), 219-225. doi: 10.11648/j.ijcu.20250902.30
@article{10.11648/j.ijcu.20250902.30,
author = {Epoupa Ngalle Frantz Guy and Mekeme Mekeme Junior Barthelemy and Fouda Jean Cedrick and Wafo Menewa Philippe Dorcas and Ngandeu Jerry Marcel and Kpanou Yellem Achille and Kuwong Mbonyam Patrick and Fouda Pierre Joseph},
title = {Open Retropubic Radical Prostatectomy: Experience in Cameroon},
journal = {International Journal of Clinical Urology},
volume = {9},
number = {2},
pages = {219-225},
doi = {10.11648/j.ijcu.20250902.30},
url = {https://doi.org/10.11648/j.ijcu.20250902.30},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20250902.30},
abstract = {Introduction: Prostate cancer is a slow-growing hormone-dependent malignant tumor that can have negative impacts at short or long term. There are many treatment options for localized prostate cancer, but most of them are of limited access in sub-Saharan Africa. Open retropubic radical prostatectomy presents a challenge in terms of early diagnosis of prostate cancer. The aim of our study was to share our experience in the field and to report patient outcomes on short and medium term. Methodology: Our study was retrospective, covering all patients who underwent open retropubic radical prostatectomy in the urology departments of Yaounde Central Hospital, Douala General Hospital, and Catholic Hospital of the Love of Our Lady in Douala over a 10-year period (2013-2023). We studied the progression of the disease and quality of life after surgery. This assessment was mainly carried out using validated self-administered questionnaires, the ICIQ (International Consultation Incontinence Questionnaire) for urinary incontinence and the IIEF 5 (International Index of Erectile Function) for erectile dysfunction. Results: We selected five patients who had undergone Open Retropubic Radical Prostatectomy (ORRP). The average age was 62.8 years. Total PSA was the postoperative biologic follow-up parameter. One patient had received hormone therapy and salvage radiotherapy, while two others were in remission. In terms of lower urinary function, three patients had urinary incontinence (UI). All of these disorders were treated with appropriate perineal physiotherapy and an anticholinergic agent. In terms of erectile function, three patients had erectile dysfunction. Anastomotic site stenosis was found in three patients. Conclusion: Surgical treatment of localized prostate cancer allows for cancer control and, in some cases, sexual and urinary function impairment is observed. We were thus able to evaluate the short- and medium-term cancer and functional outcomes in patients who underwent ORRP in two cities in Cameroon.},
year = {2025}
}
TY - JOUR T1 - Open Retropubic Radical Prostatectomy: Experience in Cameroon AU - Epoupa Ngalle Frantz Guy AU - Mekeme Mekeme Junior Barthelemy AU - Fouda Jean Cedrick AU - Wafo Menewa Philippe Dorcas AU - Ngandeu Jerry Marcel AU - Kpanou Yellem Achille AU - Kuwong Mbonyam Patrick AU - Fouda Pierre Joseph Y1 - 2025/12/31 PY - 2025 N1 - https://doi.org/10.11648/j.ijcu.20250902.30 DO - 10.11648/j.ijcu.20250902.30 T2 - International Journal of Clinical Urology JF - International Journal of Clinical Urology JO - International Journal of Clinical Urology SP - 219 EP - 225 PB - Science Publishing Group SN - 2640-1355 UR - https://doi.org/10.11648/j.ijcu.20250902.30 AB - Introduction: Prostate cancer is a slow-growing hormone-dependent malignant tumor that can have negative impacts at short or long term. There are many treatment options for localized prostate cancer, but most of them are of limited access in sub-Saharan Africa. Open retropubic radical prostatectomy presents a challenge in terms of early diagnosis of prostate cancer. The aim of our study was to share our experience in the field and to report patient outcomes on short and medium term. Methodology: Our study was retrospective, covering all patients who underwent open retropubic radical prostatectomy in the urology departments of Yaounde Central Hospital, Douala General Hospital, and Catholic Hospital of the Love of Our Lady in Douala over a 10-year period (2013-2023). We studied the progression of the disease and quality of life after surgery. This assessment was mainly carried out using validated self-administered questionnaires, the ICIQ (International Consultation Incontinence Questionnaire) for urinary incontinence and the IIEF 5 (International Index of Erectile Function) for erectile dysfunction. Results: We selected five patients who had undergone Open Retropubic Radical Prostatectomy (ORRP). The average age was 62.8 years. Total PSA was the postoperative biologic follow-up parameter. One patient had received hormone therapy and salvage radiotherapy, while two others were in remission. In terms of lower urinary function, three patients had urinary incontinence (UI). All of these disorders were treated with appropriate perineal physiotherapy and an anticholinergic agent. In terms of erectile function, three patients had erectile dysfunction. Anastomotic site stenosis was found in three patients. Conclusion: Surgical treatment of localized prostate cancer allows for cancer control and, in some cases, sexual and urinary function impairment is observed. We were thus able to evaluate the short- and medium-term cancer and functional outcomes in patients who underwent ORRP in two cities in Cameroon. VL - 9 IS - 2 ER -