Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women

Daniel Doupa; Jean Luc Faye; Fatimata Mbaye; Sidy Ka; Ahmadou Dem; Mamadou Kane; Mbacké Sembène

doi:doi:10.11648/j.ijgg.20150304.11

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Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women

Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, Mamadou Kane, Mbacké Sembène

Published in International Journal of Genetics and Genomics (Volume 3, Issue 4)

Received: 15 July 2015 Accepted: 23 July 2015 Published: 1 August 2015

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Abstract

While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.

Published in	International Journal of Genetics and Genomics (Volume 3, Issue 4)
DOI	10.11648/j.ijgg.20150304.11
Page(s)	36-42
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Breast, Benign, Tumors, Cytochrome b, Variability, Evolution, Senegal

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APA Style

Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. (2015). Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. International Journal of Genetics and Genomics, 3(4), 36-42. https://doi.org/10.11648/j.ijgg.20150304.11

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ACS Style

Daniel Doupa; Jean Luc Faye; Fatimata Mbaye; Sidy Ka; Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int. J. Genet. Genomics 2015, 3(4), 36-42. doi: 10.11648/j.ijgg.20150304.11

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AMA Style

Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int J Genet Genomics. 2015;3(4):36-42. doi: 10.11648/j.ijgg.20150304.11

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@article{10.11648/j.ijgg.20150304.11,
  author = {Daniel Doupa and Jean Luc Faye and Fatimata Mbaye and Sidy Ka and Ahmadou Dem and Mamadou Kane and Mbacké Sembène},
  title = {Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women},
  journal = {International Journal of Genetics and Genomics},
  volume = {3},
  number = {4},
  pages = {36-42},
  doi = {10.11648/j.ijgg.20150304.11},
  url = {https://doi.org/10.11648/j.ijgg.20150304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20150304.11},
  abstract = {While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.},
 year = {2015}
}

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TY  - JOUR
T1  - Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women
AU  - Daniel Doupa
AU  - Jean Luc Faye
AU  - Fatimata Mbaye
AU  - Sidy Ka
AU  - Ahmadou Dem
AU  - Mamadou Kane
AU  - Mbacké Sembène
Y1  - 2015/08/01
PY  - 2015
N1  - https://doi.org/10.11648/j.ijgg.20150304.11
DO  - 10.11648/j.ijgg.20150304.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 36
EP  - 42
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20150304.11
AB  - While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.
VL  - 3
IS  - 4
ER  -

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Author Information

Daniel Doupa

Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Jean Luc Faye

Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Fatimata Mbaye

Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Sidy Ka

Cancer Institut, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
Ahmadou Dem

Cancer Institut, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, Dakar, Senegal
Mamadou Kane

Sudanian Sahel Animal Populations Biology (BIOPASS), Research Institute for Development, IRD / Bel-Air, Senegal
Mbacké Sembène

Department of Biology Animal, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal

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Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. (2015). Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. International Journal of Genetics and Genomics, 3(4), 36-42. https://doi.org/10.11648/j.ijgg.20150304.11

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ACS Style

Daniel Doupa; Jean Luc Faye; Fatimata Mbaye; Sidy Ka; Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int. J. Genet. Genomics 2015, 3(4), 36-42. doi: 10.11648/j.ijgg.20150304.11

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AMA Style

Daniel Doupa, Jean Luc Faye, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, et al. Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women. Int J Genet Genomics. 2015;3(4):36-42. doi: 10.11648/j.ijgg.20150304.11

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@article{10.11648/j.ijgg.20150304.11,
  author = {Daniel Doupa and Jean Luc Faye and Fatimata Mbaye and Sidy Ka and Ahmadou Dem and Mamadou Kane and Mbacké Sembène},
  title = {Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women},
  journal = {International Journal of Genetics and Genomics},
  volume = {3},
  number = {4},
  pages = {36-42},
  doi = {10.11648/j.ijgg.20150304.11},
  url = {https://doi.org/10.11648/j.ijgg.20150304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20150304.11},
  abstract = {While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Implication of the Cytochrome b Mutations in the Evolution of Breast Benign Tumors Among Senegalese Women
AU  - Daniel Doupa
AU  - Jean Luc Faye
AU  - Fatimata Mbaye
AU  - Sidy Ka
AU  - Ahmadou Dem
AU  - Mamadou Kane
AU  - Mbacké Sembène
Y1  - 2015/08/01
PY  - 2015
N1  - https://doi.org/10.11648/j.ijgg.20150304.11
DO  - 10.11648/j.ijgg.20150304.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 36
EP  - 42
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20150304.11
AB  - While the studies linking the germ line mtDNA mutations to cancer raise many ambiguities because of its high genetic variability, the study of somatic mutations of this one, is proved to be decisive in the identifying of mutations involved in the genesis and evolution of tumors. In the present study, we determined the implication of the Cytochrome b mutations in the evolution of breast benign tumors among Senegalese women. This one is about, with the sequencing-PCR, to research mutations of Cytochrome b, to evaluate their importance among a benign tissues group compared to another healthy tissues group; and thence, to determine the effect of the natural selection on the observed variability. The analysis of mutations profiles of Cytochrome b in benign tissues allowed seeing that 50% of them have led to a change in amino acid and 12.5% to a shift in the reading frame. Moreover, the analysis of selection signature indicated that these mutations were subjected to a positive selection. The results also revealed that the population of benign cells was growing rapidly from an ancestral population sparse. These observations have enabled to accept the hypothesis that Cytochrome b mutations would be involved in the evolution of breast benign tumors among Senegalese women.
VL  - 3
IS  - 4
ER  -

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