Outcome of Choroid Plexus Cauterization with Endoscopic 3<sup>rd</sup> Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect

Ahmed Zahe; Mahmoud Saad; Abdelghany Elshamy

doi:doi:10.11648/j.ijn.20190302.14

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Outcome of Choroid Plexus Cauterization with Endoscopic 3^rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect

Ahmed Zahe, Mahmoud Saad, Abdelghany Elshamy

Published in International Journal of Neurosurgery (Volume 3, Issue 2)

Received: 20 November 2019 Accepted: 3 December 2019 Published: 10 December 2019

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Abstract

Background: Different surgical management of infants suffering neural tube defects (NTD) associated hydrocephalus were reported in the literature. Great debate whether combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) is more effective than ventriculoperitoneal (VP) shuntfor management of congenital hydrocephalus secondary to neural tube defects ininfants younger than 1 year of age. Purpose: To evaluate and compare the therapeutic efficacy of ETV combined with CPC versus VP shunts in infants with infantile hydrocephalus associated with NTD. Methods: Thirty infants with infantile NTD associated hydrocephalus (de novo), were equally divided and randomly allocated to each intervention group either ETV/CPC or VP shunts). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP) and/or hydrocephalic metrics (fontanelle quality, HC, and ventricular size) were also documented and compared between two groups. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test and P=0.05 or less was considered statistically significant. Results: Of the total thirty patients included in the study, thirteen patients (43.3%) were male and seventeen were female (56.7%) with mean age of 80.3±11.5 days. Twenty patients (66%) were under 6 months of age. The overall success rate in 1-year follow-up was 54% and 60% for VP shunt and ETV/CPC, respectively; with the difference being not statistically significant. Conclusion: Combined ETV-CPC is considered a successful surgical option for treatment of infantile hydrocephalus associated with NTD; achieving success rate better than VPS implantation.

Published in	International Journal of Neurosurgery (Volume 3, Issue 2)
DOI	10.11648/j.ijn.20190302.14
Page(s)	32-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Endoscopic Third Ventriculostomy, Choroid Plexus Cauterization, Neural Tube Defect, Hydrocephalus

References

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APA Style

Ahmed Zahe, Mahmoud Saad, Abdelghany Elshamy. (2019). Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. International Journal of Neurosurgery, 3(2), 32-37. https://doi.org/10.11648/j.ijn.20190302.14

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ACS Style

Ahmed Zahe; Mahmoud Saad; Abdelghany Elshamy. Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. Int. J. Neurosurg. 2019, 3(2), 32-37. doi: 10.11648/j.ijn.20190302.14

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AMA Style

Ahmed Zahe, Mahmoud Saad, Abdelghany Elshamy. Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. Int J Neurosurg. 2019;3(2):32-37. doi: 10.11648/j.ijn.20190302.14

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@article{10.11648/j.ijn.20190302.14,
  author = {Ahmed Zahe and Mahmoud Saad and Abdelghany Elshamy},
  title = {Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect},
  journal = {International Journal of Neurosurgery},
  volume = {3},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijn.20190302.14},
  url = {https://doi.org/10.11648/j.ijn.20190302.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20190302.14},
  abstract = {Background: Different surgical management of infants suffering neural tube defects (NTD) associated hydrocephalus were reported in the literature. Great debate whether combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) is more effective than ventriculoperitoneal (VP) shuntfor management of congenital hydrocephalus secondary to neural tube defects ininfants younger than 1 year of age. Purpose: To evaluate and compare the therapeutic efficacy of ETV combined with CPC versus VP shunts in infants with infantile hydrocephalus associated with NTD. Methods: Thirty infants with infantile NTD associated hydrocephalus (de novo), were equally divided and randomly allocated to each intervention group either ETV/CPC or VP shunts). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP) and/or hydrocephalic metrics (fontanelle quality, HC, and ventricular size) were also documented and compared between two groups. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test and P=0.05 or less was considered statistically significant. Results: Of the total thirty patients included in the study, thirteen patients (43.3%) were male and seventeen were female (56.7%) with mean age of 80.3±11.5 days. Twenty patients (66%) were under 6 months of age. The overall success rate in 1-year follow-up was 54% and 60% for VP shunt and ETV/CPC, respectively; with the difference being not statistically significant. Conclusion: Combined ETV-CPC is considered a successful surgical option for treatment of infantile hydrocephalus associated with NTD; achieving success rate better than VPS implantation.},
 year = {2019}
}

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TY  - JOUR
T1  - Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect
AU  - Ahmed Zahe
AU  - Mahmoud Saad
AU  - Abdelghany Elshamy
Y1  - 2019/12/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijn.20190302.14
DO  - 10.11648/j.ijn.20190302.14
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 32
EP  - 37
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20190302.14
AB  - Background: Different surgical management of infants suffering neural tube defects (NTD) associated hydrocephalus were reported in the literature. Great debate whether combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) is more effective than ventriculoperitoneal (VP) shuntfor management of congenital hydrocephalus secondary to neural tube defects ininfants younger than 1 year of age. Purpose: To evaluate and compare the therapeutic efficacy of ETV combined with CPC versus VP shunts in infants with infantile hydrocephalus associated with NTD. Methods: Thirty infants with infantile NTD associated hydrocephalus (de novo), were equally divided and randomly allocated to each intervention group either ETV/CPC or VP shunts). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP) and/or hydrocephalic metrics (fontanelle quality, HC, and ventricular size) were also documented and compared between two groups. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test and P=0.05 or less was considered statistically significant. Results: Of the total thirty patients included in the study, thirteen patients (43.3%) were male and seventeen were female (56.7%) with mean age of 80.3±11.5 days. Twenty patients (66%) were under 6 months of age. The overall success rate in 1-year follow-up was 54% and 60% for VP shunt and ETV/CPC, respectively; with the difference being not statistically significant. Conclusion: Combined ETV-CPC is considered a successful surgical option for treatment of infantile hydrocephalus associated with NTD; achieving success rate better than VPS implantation.
VL  - 3
IS  - 2
ER  -

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Author Information

Ahmed Zahe

Department of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Mahmoud Saad

Department of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Abdelghany Elshamy

Department of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Ahmed Zahe, Mahmoud Saad, Abdelghany Elshamy. (2019). Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. International Journal of Neurosurgery, 3(2), 32-37. https://doi.org/10.11648/j.ijn.20190302.14

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ACS Style

Ahmed Zahe; Mahmoud Saad; Abdelghany Elshamy. Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. Int. J. Neurosurg. 2019, 3(2), 32-37. doi: 10.11648/j.ijn.20190302.14

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AMA Style

Ahmed Zahe, Mahmoud Saad, Abdelghany Elshamy. Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect. Int J Neurosurg. 2019;3(2):32-37. doi: 10.11648/j.ijn.20190302.14

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@article{10.11648/j.ijn.20190302.14,
  author = {Ahmed Zahe and Mahmoud Saad and Abdelghany Elshamy},
  title = {Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect},
  journal = {International Journal of Neurosurgery},
  volume = {3},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijn.20190302.14},
  url = {https://doi.org/10.11648/j.ijn.20190302.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20190302.14},
  abstract = {Background: Different surgical management of infants suffering neural tube defects (NTD) associated hydrocephalus were reported in the literature. Great debate whether combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) is more effective than ventriculoperitoneal (VP) shuntfor management of congenital hydrocephalus secondary to neural tube defects ininfants younger than 1 year of age. Purpose: To evaluate and compare the therapeutic efficacy of ETV combined with CPC versus VP shunts in infants with infantile hydrocephalus associated with NTD. Methods: Thirty infants with infantile NTD associated hydrocephalus (de novo), were equally divided and randomly allocated to each intervention group either ETV/CPC or VP shunts). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP) and/or hydrocephalic metrics (fontanelle quality, HC, and ventricular size) were also documented and compared between two groups. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test and P=0.05 or less was considered statistically significant. Results: Of the total thirty patients included in the study, thirteen patients (43.3%) were male and seventeen were female (56.7%) with mean age of 80.3±11.5 days. Twenty patients (66%) were under 6 months of age. The overall success rate in 1-year follow-up was 54% and 60% for VP shunt and ETV/CPC, respectively; with the difference being not statistically significant. Conclusion: Combined ETV-CPC is considered a successful surgical option for treatment of infantile hydrocephalus associated with NTD; achieving success rate better than VPS implantation.},
 year = {2019}
}

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TY  - JOUR
T1  - Outcome of Choroid Plexus Cauterization with Endoscopic 3rd Ventriculostomy vs Ventricular Shunting in Management of Hydrocephalus Secondary to Neural Tube Defect
AU  - Ahmed Zahe
AU  - Mahmoud Saad
AU  - Abdelghany Elshamy
Y1  - 2019/12/10
PY  - 2019
N1  - https://doi.org/10.11648/j.ijn.20190302.14
DO  - 10.11648/j.ijn.20190302.14
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 32
EP  - 37
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20190302.14
AB  - Background: Different surgical management of infants suffering neural tube defects (NTD) associated hydrocephalus were reported in the literature. Great debate whether combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) is more effective than ventriculoperitoneal (VP) shuntfor management of congenital hydrocephalus secondary to neural tube defects ininfants younger than 1 year of age. Purpose: To evaluate and compare the therapeutic efficacy of ETV combined with CPC versus VP shunts in infants with infantile hydrocephalus associated with NTD. Methods: Thirty infants with infantile NTD associated hydrocephalus (de novo), were equally divided and randomly allocated to each intervention group either ETV/CPC or VP shunts). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP) and/or hydrocephalic metrics (fontanelle quality, HC, and ventricular size) were also documented and compared between two groups. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test and P=0.05 or less was considered statistically significant. Results: Of the total thirty patients included in the study, thirteen patients (43.3%) were male and seventeen were female (56.7%) with mean age of 80.3±11.5 days. Twenty patients (66%) were under 6 months of age. The overall success rate in 1-year follow-up was 54% and 60% for VP shunt and ETV/CPC, respectively; with the difference being not statistically significant. Conclusion: Combined ETV-CPC is considered a successful surgical option for treatment of infantile hydrocephalus associated with NTD; achieving success rate better than VPS implantation.
VL  - 3
IS  - 2
ER  -

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