Effect of Nutrients and Phytochemical Compounds of <i>Solanum melongena</i> (Eggplants) on Cognitive Protection in Rats

Hermine Doungue Tsafack; Mariane Matchinda Tchinda; Michel Pegui Kemtsop; Geradin Joel Tagne Tueguem; Anne Pascale Kengne Nouemsi; Hilaire Macaire Womeni

doi:doi:10.11648/j.jdmp.20241002.11

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Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats

Hermine Doungue Tsafack^*

, Mariane Matchinda Tchinda, Michel Pegui Kemtsop

, Geradin Joel Tagne Tueguem

, Anne Pascale Kengne Nouemsi

, Hilaire Macaire Womeni

Published in Journal of Diseases and Medicinal Plants (Volume 10, Issue 2)

Received: 21 February 2024 Accepted: 22 March 2024 Published: 11 April 2024

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Abstract

Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (P<0.05). The group Sm10% showed the best memory capacity radial maze tests (0.73 n/min), the lowest malondialdehyde level and acetylcholinesterase activity (12.45 µmole/g and 0.11nmol/min/mg protein respectively) (P<0.05). Purple Solanum melongena could be used to protect neuron functions.

Published in	Journal of Diseases and Medicinal Plants (Volume 10, Issue 2)
DOI	10.11648/j.jdmp.20241002.11
Page(s)	17-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nutrients, Phytochemical Compounds, Cognitive Protection, Solanum melongena

References

[1]	Alpna, T., Subbiah, P. A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation International Journal of Molecular Sciences. 2023, 24(2), 1615; https://doi.org/10.3390/ijms24021615
[2]	Stephenson, J., Nutma, E., Valk, P., Amor, S. Inflammation in CNS Neurodegenerative diseases. Immunology. 2018, 154 (2): 121-136; https://doi.org/10.1111/imm.12922
[3]	Javaid, F., Giebel, C., klan, M., Hashim, M. Epidemiology of Alzheimer’s disease and other dementias: rising global burden and forecasted trends, Research. 2021. 10,425; https://doi.org/10.12688/f1000research.50786.1
[4]	Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., Ferri C. The global prevalence of dementia: A systematic review and meta analysis. Alzheimers Dement. 2013, 9(1): 63 75; https://doi.org/10.1016/j.jalz.2012.11.007
[5]	Kyung, H., Myeounghoon, C., Bae, H. Neuroprotective effect of antioxidants in the brain; International Journal of molecular Sciences. 2020, 20 21(19): 7152. https://doi.org/10.3390/ijms21197152
[6]	Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera J., Filip, M. Oxidative stress in neurodegenerative diseases. Mol. Neurobiol. 2016, 53: 4094–4125. https://doi.org/10.1007/s12035-015-9337-5
[7]	Liu, Z., Zhou, T., Ziegler, A., Dimitrion, P., Zuo, L. Oxidative stress in neurodegenerative diseases: From molecular mechanisms to clinical applications. Oxid. Med. Cell Longev. 2017, 2525967, https://doi.org/10.1155/2017/2525967
[8]	High Authorities of Health (HAS). Evaluation of drugs. Transparence commission. Report on the evaluation of drugs used in the symptomatic treatment of Alzheimer diseases. 2016, http://www.has-sante.fr/portail/upload/docs/application/pdf/201610
[9]	Neurodegenerative diseases plan 2014-2019 Ministry of social affairs, heath and women right. 2014, http://solidarites-sante.gouv.fr/IMG/pdf
[10]	Adan, R., van der Beek, E., Buitelaar J. Nutritional psychiatry: Towards improving mental health by what you eat. Eur. Neuropsychopharmacol. 2019, 29(12): 1321–1332.
[11]	Angeloni, C., Businaro, R., Vauzour, D. The role of diet in preventing and reducing cognitive decline. Curr. Opin. Psychiatry. 2020. 33(4): 432–438.
[12]	Doungue, H., Kengne, A., Womeni H. (2020). Antioxidant and Neuroprotective Activities of the Mesocarp of Raphia hookeri Fruit against Aluminum Chloride-Induced Neurotoxicity in Rats. Food and Nutrition Sciences. 2020, 11, 396-415; https://doi.org/10.4236/fns.2020.115029
[13]	Somawathi, K., Rizliya, V., Wijesinghe, D., Madhujith T. Antioxidant Activity and Total Phenolic Content of Different Skin Coloured Brinjal (Solanum melongena) Tropical Agricultural Research. 2014, 26 (1): 152-161; https://doi.org/10.4038/tar.v26i1.8080
[14]	Silva, P., Pereira, E., Melgar, B., Stjkovic, D., Calhelha, C., Pereira, C., Qbreu, V., Pereira, R., Barros, L. Eggplant Solanum melongena L. and Bio- residues a source of nutrients, bioactive compounds and food colorants, using innovative food technologies. Journal of applicate Sciences. 2021. 11(1), 151; https://doi.org/10.3390/app11010151
[15]	Gürbüza, N., Uluişik, S., Frarya, A., Fraryc A., Doğanlara S. Health benefits and bioactive compounds of eggplant. Food Chemistry. 2018, https://doi.org/10.1016/j.foodchem
[16]	Kwon, S., Lee, H., Kim, J. Neuroprotective effects of chlorogenic acid on scopolamine induced amnesia via anti-acetylcholinesterase and antioxidative activities in mice. Europeen Journal of Pharmacology. 2010, 649: 1-3; https://doi.org/10.1016/j.ejphar.2010.09.001
[17]	Ogunsuyi, B., Olasehinde, A., Oboh, G. Neuroprotective properties of Solanum leaves in transgenic Drosophila melanogaster model of Alzheimer's disease. National Libreray of Medecine. 2022, 27(6): 587-598; https://doi.org/10.1080/1354750X.2022.2077446
[18]	Yılmaz, I., Temel, I., Gursoy, S., Dogan, Z., Turkoz, Y. Effects of sun dried organic apricot on some serum mineral levels in rats, International Journal of Pharmaceuticals Research. 2012, 2(03): 62-67.
[19]	Womeni, H., Djikeng, F., Anjaneyulu, B., Karuna, M., Prasad, R., Linder, M. Oxidative Stabilization of RBD Palm Olein under Forced Storage Conditions by Old Cameroonian Green Tea Leaves Methanolic Extract. Jounal of Nutrition and Food Science. 2016, 3, 33-40; https://doi.org/10.1016/j.nfs.2016.03.002
[20]	AOAC, Official Method of Analysis of the Association of Official Analytical Chemists. 1990. No. 934.06, AOAC, Arlington, Texas.
[21]	AOAC, Official Methods of Analysis of Association of Official Analytical Chemistry International, Association of Analytical Communities, Gaithersburg, MD, 2005.
[22]	Mohamed, Ahmed, I., Al Juhaimi, F., Osman, M. “Effect of oven roasting treatment on the antioxidant activity, phenolic compounds, fatty acids, minerals, and protein profile of Samh (Mesembryanthemum forsskalei Hochst) seeds,” Lebensmittel-Wissenschaft and Technologie. 2020, 131, Article ID 109825.
[23]	Gao, X., Ohlander, M., Jeppsson, N., Bjork, L., Trajkovski, V. Changes in Antioxidant Effects and Their Relationship to Phytonutrients in Fruits of Sea Buckthorn (Hippophae rhamnoides L) during Maturation. Journal of Agricultural and Food Chemistry. 2000, 48, 1485-1490; https://doi.org/10.1021/jf991072g
[24]	Quettier, D., Gressier, B., Vasseur, J., Dine, T., Brunet, C., Luyckx, M., Cayin, C., Bailleul, F., Trotin F. Phenolic Compounds and Antioxidant Activities of Buckwheat (Fagopyrum esculentum Moench) Hulls and Flour. Journal of Ethnopharmacology. 2000, 72, 35-42; https://doi.org/10.1016/S0378-8741(00)00196-3
[25]	Braca, A., Sortino, C., Politi, M. Antioxidant Activity of Flavonoïds from Licanialicaniae flora. Journal of Ethnopharmacology 2002. 79, 379-38; https://doi.org/10.1016/S0378-8741(01)00413-5
[26]	Oyaizu, M. Studies on Products of Browning Reactions: Antioxidative Activities of Products of Browning Reaction Prepared from Glucosamine. Japan Journal of Nutrition. 1986, 44, 307-315; https://doi.org/10.5264/eiyogakuzashi.44.307
[27]	OECD Directrices lines of OCDE for testing chemicals pruduct № 425 acute oral toxicity adjustement Method for OECD. 2008, 1-29.
[28]	Morris, J., McKeel D., Storandt M., Rubin E., Price L., Grant E. Very Mild Alzheimer’s Disease: Informant-Based Clinical, Psychometric, and Pathologic Distinction from Normal Aging. Neurology. 1991, 41, 469-478; https://doi.org/10.1212/WNL.41.4.4
[29]	Olton and Samuelson Eight-Arm Radial Labyrinth Protocol. Neurology. 1976, 40, 269-272.
[30]	Gornall, A., Gomez-Caravaca, A., Gomez-Romero, M., Arraez-Roman D., Segura-Carretero A., Barwill G., David M. Determination of Serum Protein by Eanms of the Buiret Reaction. Journal of Biological Chemistry. 1949. 177, 751-766.
[31]	Ellman, G. Quantitative determination of Peptide by Sulfhydryl (-SH) Groups. Archives of Biochemistry and Biophysics 1959, 82, 70-77; https://doi.org/10.1016/0003-9861(59)90090-6
[32]	Sinha, K. Colorimetric Assay of Catalase. Analytical Biochemistry. 1972, 47, 389-394; https://doi.org/10.1016/0003-2697(72)90132-7
[33]	Yagi, K. Simple Fluorometric Assay for Lipoperoxyde in Blood Plasma. Biology and Medicine 1976, 15, 212-216; https://doi.org/10.1016/0006-2944(76)90049-1
[34]	Ellman, G., Courtney, K., Andres, V., Featherstone, R. A New and Rapid Colorimetric determination of Acetylcholinesterase Activity. Biochemical Pharmacology. 1961, 7, 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
[35]	Trumbo, P., Schlicker, S., Yates, A., Poos, M. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J. Am. Diet. Assoc. 2002, 102(11): 1621–1630. (PMID: 12449285).
[36]	FAO/WHO. 1988. Recommended nutrient reference values for food labelling purposes, report of a Joint FAO/WHO Expert Consultation on Recommended Allowances of Nutrients for Food Labelling Purposes, held in Helsinki, Finland, 12-16 September 1988. Helsinki, Ministry of Trade and Industry.
[37]	Senga, P., Opota, D., Tamba, A., Tona, G., Kambu, O., Covaci, A., Apers, S., Pieters, L., Cimanga, K. Chemical composition and nutritive value study of the seed oil of Adenanthera pavonina L. (Fabaceae) growing in Democratic Republic of Congo. International journal of Pharmtech Research. 2013, 5(1): 205-216.
[38]	Naeem, Y. and Ugur, S. Nutritional Content and Health Benefits of Eggplant Turkish Journal of Agriculture-Food Science and Technology. 2019, 7(sp3): 31-36, https://doi.org/10.24925/turjaf.v7isp3.31-36.3146
[39]	Andzouana, M., Mombouli, J. Assessment of the Chemical and Phytochemical Constituents of the Leaves of a Wild Vegetable-Ochthocharis dicellandroides (Gilg). Pakistan Journal of Nutrition. 2012, 11(1): 94-99.
[40]	Li, Z., Liu, Y., Wei R., Yong, V., Xue, M. The Important Role of Zinc in Neurological Diseases, Biomolecules. 2023, 13(1): 28. https://doi.org/10.3390/biom13010028
[41]	Tremoccoldi, M., Rosalen, P., Marcelo, F., Adna, M., Carina, P., Erica D., Jonas R. Rizzato Priscilla, A. Exploration of Avocado By-Products as Natural Sources of Bioactive Compounds. 2018, Plos one, 13, 0192577; https://doi.org/10.1371/journal.pone.0192577
[42]	Jarerat, A., Chairat, T., Chanthana, C., Hataitip, N. Enhancement of antioxidant activity and bioactive compounds in eggplants using postharvest leds irradiation" horticulturae. 2022, 8, 2: 134; https://doi.org/10.3390/horticulturae 8020134
[43]	Oluyori, P., Dada, A., Inyinbor, A. Phytochemical analysis and antioxidant potential of Raphia hookeri leaf and epicarp. International Research Journal of Pure and Applied Chemistry. 2018, 34, 157-164; https://doi.org/10.13005/ojc/340608
[44]	Ayouaz, S., Koss-Mikołajczyk, I., Adjeroud-Abdellatif, N., Bartoszek, A., Arab, R., Aji Muhammad, D., Nur D., Madani, K. Anticarcinogenic and antioxidant activities of leaves and flowers hydroalcoholic extracts of Nerium oleander L.: PCA analysis and phytochemical content by FTIR analysis. The North African Journal of Food and Nutrition Research. 2023, 7 (15): 1-8; https://doi.org/10.51745/najfnr
[45]	Souri, E., Amin, G., Farsam, H., Barazandeh, M. Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts. Daru 2008, 16 (2): 83-87.
[46]	Young, Y., Sung-Hee, J., Hee-Yeon, J., Denis, N., Seon-Il J., Young-Soo, K. Chlorogenic acid-rich Solanum melongena extract has protective potential against rotenone-induced neurotoxicity in PC-12 cells. Journal of Biochemistry. 2019, https://doi.org/10.1111/jfbc.12999
[47]	Chang, Y., Bai, M., Zhang, X., Shen, S., Hou, J., Yao, G., Huang, X., Song, S. Neuroprotective and acetylcholinesterase inhibitory activities of alkaloids from Solanum lyratum Thunb: An in vitro and in silico analyses Phytochimistry 2023, 209; https://doi.org/10.1016/j.phytochem.2023.113623
[48]	Viacheslav, I., Aleksandra, S., Anton, S., Anatoly, A., Irina, B. Modeling of Neurodegenerative Diseases: ‘Step by Step’ and ‘Network’ Organization of the Complexes of Model Systems. International Journal of Molecular Sciences. 2023, 24(1), 604; https://doi.org/10.3390/ijms24010604
[49]	Kumar, A., Mallik B., Rijal, S., Changdar, N., Mudgal, J., Shenoy, R. Dietary oils ameliorate aluminum chloride-induced memory deficit in wistar rats. Parmacognosy magazine. 2019, 15: 36-42. https://phcog.com/article/view/2019/15/60/36-42 (cited 2020 April30).
[50]	Adasme, T., hidalgo, C., Herrera-molina, R.•Emerging views and players in neuronal calcium signaling: synaptic plasticity, learning/memory, aging and neuroinflammation Cell. Neurosci. 2023, 17: 1197417. https://doi.org/10.3389/fncel
[51]	Watanabe, C., Wolffram, S., Ader, P., Rimbach, G., Packer, L., Maguire, J., Shultz, P. The in vivo modulatory effects of the herbal medicine Ginkgo biloba, procedure. Natl. Academic Sciences USA. 2001, 98(12): 6577-65780; https://doi.org/10.1073/pnas.111126298

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Tsafack, H. D., Tchinda, M. M., Kemtsop, M. P., Tueguem, G. J. T., Nouemsi, A. P. K., et al. (2024). Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . Journal of Diseases and Medicinal Plants, 10(2), 17-28. https://doi.org/10.11648/j.jdmp.20241002.11

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Tsafack, H. D.; Tchinda, M. M.; Kemtsop, M. P.; Tueguem, G. J. T.; Nouemsi, A. P. K., et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . J. Dis. Med. Plants 2024, 10(2), 17-28. doi: 10.11648/j.jdmp.20241002.11

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Tsafack HD, Tchinda MM, Kemtsop MP, Tueguem GJT, Nouemsi APK, et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . J Dis Med Plants. 2024;10(2):17-28. doi: 10.11648/j.jdmp.20241002.11

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@article{10.11648/j.jdmp.20241002.11,
  author = {Hermine Doungue Tsafack and Mariane Matchinda Tchinda and Michel Pegui Kemtsop and Geradin Joel Tagne Tueguem and Anne Pascale Kengne Nouemsi and Hilaire Macaire Womeni},
  title = {Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats
},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {10},
  number = {2},
  pages = {17-28},
  doi = {10.11648/j.jdmp.20241002.11},
  url = {https://doi.org/10.11648/j.jdmp.20241002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20241002.11},
  abstract = {Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions.
},
 year = {2024}
}

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TY  - JOUR
T1  - Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats

AU  - Hermine Doungue Tsafack
AU  - Mariane Matchinda Tchinda
AU  - Michel Pegui Kemtsop
AU  - Geradin Joel Tagne Tueguem
AU  - Anne Pascale Kengne Nouemsi
AU  - Hilaire Macaire Womeni
Y1  - 2024/04/11
PY  - 2024
N1  - https://doi.org/10.11648/j.jdmp.20241002.11
DO  - 10.11648/j.jdmp.20241002.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 17
EP  - 28
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20241002.11
AB  - Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions.

VL  - 10
IS  - 2
ER  -

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Hermine Doungue Tsafack

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon

Contact Email

http://orcid.org/0009-0000-7203-3336
Mariane Matchinda Tchinda

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon
Michel Pegui Kemtsop

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon

http://orcid.org/0009-0005-8491-5041
Geradin Joel Tagne Tueguem

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon

http://orcid.org/0009-0006-2400-4454
Anne Pascale Kengne Nouemsi

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Yaounde, Cameroon

http://orcid.org/0000-0002-1729-9796
Hilaire Macaire Womeni

Research Unit of Biochemistry, Medicinal Plants, Food Sciences and Nutrition, Department of Biochemistry, University of Dschang, Dschang, Cameroon

http://orcid.org/0000-0001-6893-2865

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Tsafack, H. D., Tchinda, M. M., Kemtsop, M. P., Tueguem, G. J. T., Nouemsi, A. P. K., et al. (2024). Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . Journal of Diseases and Medicinal Plants, 10(2), 17-28. https://doi.org/10.11648/j.jdmp.20241002.11

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Tsafack, H. D.; Tchinda, M. M.; Kemtsop, M. P.; Tueguem, G. J. T.; Nouemsi, A. P. K., et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . J. Dis. Med. Plants 2024, 10(2), 17-28. doi: 10.11648/j.jdmp.20241002.11

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Tsafack HD, Tchinda MM, Kemtsop MP, Tueguem GJT, Nouemsi APK, et al. Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats . J Dis Med Plants. 2024;10(2):17-28. doi: 10.11648/j.jdmp.20241002.11

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@article{10.11648/j.jdmp.20241002.11,
  author = {Hermine Doungue Tsafack and Mariane Matchinda Tchinda and Michel Pegui Kemtsop and Geradin Joel Tagne Tueguem and Anne Pascale Kengne Nouemsi and Hilaire Macaire Womeni},
  title = {Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats
},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {10},
  number = {2},
  pages = {17-28},
  doi = {10.11648/j.jdmp.20241002.11},
  url = {https://doi.org/10.11648/j.jdmp.20241002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20241002.11},
  abstract = {Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions.
},
 year = {2024}
}

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TY  - JOUR
T1  - Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats

AU  - Hermine Doungue Tsafack
AU  - Mariane Matchinda Tchinda
AU  - Michel Pegui Kemtsop
AU  - Geradin Joel Tagne Tueguem
AU  - Anne Pascale Kengne Nouemsi
AU  - Hilaire Macaire Womeni
Y1  - 2024/04/11
PY  - 2024
N1  - https://doi.org/10.11648/j.jdmp.20241002.11
DO  - 10.11648/j.jdmp.20241002.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 17
EP  - 28
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20241002.11
AB  - Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (PSolanum melongena could be used to protect neuron functions.

VL  - 10
IS  - 2
ER  -

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