Urinary tract infections are one of the most prevalent infectious diseases which frequently reoccur and are difficult to eradicate. OBJECTIVE: To determine the frequency of the most common gram-positive and gram-negative organisms causing urinary tract infections, as well as their sensitivity/resistance to various antibiotics in pregnant women. Methods: A total of 160 cases were included in this cross-sectional study, which was conducted at the in-patient Department of Obstetrics and Gynecology at NESCOM hospital Islamabad. All patients fulfilling the inclusion criteria were enrolled in the study. After taking consent from the patient and explaining the purpose of the study, early morning mid-stream urine samples were collected in a sterile bottle to report pus cells, epithelial cells, and bacteria. If the patient had a urinary tract infection according to the urine report, then a culture and sensitivity test was performed. Results: A total of 160 patients presenting with urinary tract infections were included in the study. The mean age of the patients was 25.06 + 10.04 years. Out of 160 patients, 120 (75%) had asymptomatic UTIs, while 40 (25%) patients had symptomatic UTIs. The most common organisms were Escherichia coli (55.6%) followed by Staphylococcus aureus (18.2%), Klebsiella pneumoniae (11.9%), Pseudomonas aeruginosa (6.9%), Staphylococcus saprophyticus (4.3%) Streptococci (1.9%) and Proteus vulgaris (1.2%). Organisms causing symptomatic UTI were Pseudomonas aeruginosa, followed by Klebsiella pneumoniae, Escherichia coli, Staphylococcus saprophyticus and Staphylococcus aureus. E. coli showed the highest sensitivity to ceftriaxone (71%) but was resistant to cephalexin (89%) and co-amoxiclav (82%). Klebsiella pneumoniae was only 76% sensitive to cefixime and 93% resistant to Co-Amoxiclav. Ceftazidime was 81% effective against Pseudomonas aeruginosa, while cefixime was 69% effective. Pseudomonas aeruginosa was 95% resistant to Cephalexin and 86% resistant to Nitrofurantoin. Staphylococcus aureus was 81% susceptible to cephalexin and 93% resistant to cefixime. Staphylococcus saprophyticus was 97% sensitive to Co-Amoxiclav and 85% resistant to Ceftazidime and Nitrofurantoin. Streptococci sp. were 95% sensitive to Cephalexin and 95% resistant to Ceftazidime 88%. Conclusion: In conclusion, the empirical evidence reaffirms that the selection of medications for the treatment of UTIs is limited due to antibiotic resistance that the prevalent microorganisms display to medications utilised in the past. Drugs like co-trimoxazole and aminopenicillins, which were once thought to be useful against uropathogens, are now infrequently used as empirical therapy in regions with high rates of antibiotic resistance.
| Published in | Journal of Gynecology and Obstetrics (Volume 10, Issue 6) |
| DOI | 10.11648/j.jgo.20221006.11 |
| Page(s) | 236-242 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sensitivity, Gram Positive, Gram Negative, Urinary Tract Infection
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APA Style
Maria Tasneem, Sadia Shoukat, Tehreem Zahid, Jahooran Mariyah Bibi Goolamnobee, Nabila Salman. (2022). Urinary Tract Infection and Antibiotic Resistance in Pregnant Women: A Single-Center Cross-Sectional Study. Journal of Gynecology and Obstetrics, 10(6), 236-242. https://doi.org/10.11648/j.jgo.20221006.11
ACS Style
Maria Tasneem; Sadia Shoukat; Tehreem Zahid; Jahooran Mariyah Bibi Goolamnobee; Nabila Salman. Urinary Tract Infection and Antibiotic Resistance in Pregnant Women: A Single-Center Cross-Sectional Study. J. Gynecol. Obstet. 2022, 10(6), 236-242. doi: 10.11648/j.jgo.20221006.11
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author = {Maria Tasneem and Sadia Shoukat and Tehreem Zahid and Jahooran Mariyah Bibi Goolamnobee and Nabila Salman},
title = {Urinary Tract Infection and Antibiotic Resistance in Pregnant Women: A Single-Center Cross-Sectional Study},
journal = {Journal of Gynecology and Obstetrics},
volume = {10},
number = {6},
pages = {236-242},
doi = {10.11648/j.jgo.20221006.11},
url = {https://doi.org/10.11648/j.jgo.20221006.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221006.11},
abstract = {Urinary tract infections are one of the most prevalent infectious diseases which frequently reoccur and are difficult to eradicate. OBJECTIVE: To determine the frequency of the most common gram-positive and gram-negative organisms causing urinary tract infections, as well as their sensitivity/resistance to various antibiotics in pregnant women. Methods: A total of 160 cases were included in this cross-sectional study, which was conducted at the in-patient Department of Obstetrics and Gynecology at NESCOM hospital Islamabad. All patients fulfilling the inclusion criteria were enrolled in the study. After taking consent from the patient and explaining the purpose of the study, early morning mid-stream urine samples were collected in a sterile bottle to report pus cells, epithelial cells, and bacteria. If the patient had a urinary tract infection according to the urine report, then a culture and sensitivity test was performed. Results: A total of 160 patients presenting with urinary tract infections were included in the study. The mean age of the patients was 25.06 + 10.04 years. Out of 160 patients, 120 (75%) had asymptomatic UTIs, while 40 (25%) patients had symptomatic UTIs. The most common organisms were Escherichia coli (55.6%) followed by Staphylococcus aureus (18.2%), Klebsiella pneumoniae (11.9%), Pseudomonas aeruginosa (6.9%), Staphylococcus saprophyticus (4.3%) Streptococci (1.9%) and Proteus vulgaris (1.2%). Organisms causing symptomatic UTI were Pseudomonas aeruginosa, followed by Klebsiella pneumoniae, Escherichia coli, Staphylococcus saprophyticus and Staphylococcus aureus. E. coli showed the highest sensitivity to ceftriaxone (71%) but was resistant to cephalexin (89%) and co-amoxiclav (82%). Klebsiella pneumoniae was only 76% sensitive to cefixime and 93% resistant to Co-Amoxiclav. Ceftazidime was 81% effective against Pseudomonas aeruginosa, while cefixime was 69% effective. Pseudomonas aeruginosa was 95% resistant to Cephalexin and 86% resistant to Nitrofurantoin. Staphylococcus aureus was 81% susceptible to cephalexin and 93% resistant to cefixime. Staphylococcus saprophyticus was 97% sensitive to Co-Amoxiclav and 85% resistant to Ceftazidime and Nitrofurantoin. Streptococci sp. were 95% sensitive to Cephalexin and 95% resistant to Ceftazidime 88%. Conclusion: In conclusion, the empirical evidence reaffirms that the selection of medications for the treatment of UTIs is limited due to antibiotic resistance that the prevalent microorganisms display to medications utilised in the past. Drugs like co-trimoxazole and aminopenicillins, which were once thought to be useful against uropathogens, are now infrequently used as empirical therapy in regions with high rates of antibiotic resistance.},
year = {2022}
}
TY - JOUR T1 - Urinary Tract Infection and Antibiotic Resistance in Pregnant Women: A Single-Center Cross-Sectional Study AU - Maria Tasneem AU - Sadia Shoukat AU - Tehreem Zahid AU - Jahooran Mariyah Bibi Goolamnobee AU - Nabila Salman Y1 - 2022/11/10 PY - 2022 N1 - https://doi.org/10.11648/j.jgo.20221006.11 DO - 10.11648/j.jgo.20221006.11 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 236 EP - 242 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20221006.11 AB - Urinary tract infections are one of the most prevalent infectious diseases which frequently reoccur and are difficult to eradicate. OBJECTIVE: To determine the frequency of the most common gram-positive and gram-negative organisms causing urinary tract infections, as well as their sensitivity/resistance to various antibiotics in pregnant women. Methods: A total of 160 cases were included in this cross-sectional study, which was conducted at the in-patient Department of Obstetrics and Gynecology at NESCOM hospital Islamabad. All patients fulfilling the inclusion criteria were enrolled in the study. After taking consent from the patient and explaining the purpose of the study, early morning mid-stream urine samples were collected in a sterile bottle to report pus cells, epithelial cells, and bacteria. If the patient had a urinary tract infection according to the urine report, then a culture and sensitivity test was performed. Results: A total of 160 patients presenting with urinary tract infections were included in the study. The mean age of the patients was 25.06 + 10.04 years. Out of 160 patients, 120 (75%) had asymptomatic UTIs, while 40 (25%) patients had symptomatic UTIs. The most common organisms were Escherichia coli (55.6%) followed by Staphylococcus aureus (18.2%), Klebsiella pneumoniae (11.9%), Pseudomonas aeruginosa (6.9%), Staphylococcus saprophyticus (4.3%) Streptococci (1.9%) and Proteus vulgaris (1.2%). Organisms causing symptomatic UTI were Pseudomonas aeruginosa, followed by Klebsiella pneumoniae, Escherichia coli, Staphylococcus saprophyticus and Staphylococcus aureus. E. coli showed the highest sensitivity to ceftriaxone (71%) but was resistant to cephalexin (89%) and co-amoxiclav (82%). Klebsiella pneumoniae was only 76% sensitive to cefixime and 93% resistant to Co-Amoxiclav. Ceftazidime was 81% effective against Pseudomonas aeruginosa, while cefixime was 69% effective. Pseudomonas aeruginosa was 95% resistant to Cephalexin and 86% resistant to Nitrofurantoin. Staphylococcus aureus was 81% susceptible to cephalexin and 93% resistant to cefixime. Staphylococcus saprophyticus was 97% sensitive to Co-Amoxiclav and 85% resistant to Ceftazidime and Nitrofurantoin. Streptococci sp. were 95% sensitive to Cephalexin and 95% resistant to Ceftazidime 88%. Conclusion: In conclusion, the empirical evidence reaffirms that the selection of medications for the treatment of UTIs is limited due to antibiotic resistance that the prevalent microorganisms display to medications utilised in the past. Drugs like co-trimoxazole and aminopenicillins, which were once thought to be useful against uropathogens, are now infrequently used as empirical therapy in regions with high rates of antibiotic resistance. VL - 10 IS - 6 ER -
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