Schiff bases are aldehyde or ketone derivatives that are made by condensation of primary amines and carbonyl compounds and have their carbonyl organization (C = O) replaced by an imine or azomethine organization (>C = N-). Schiff bases are a key ligand elegance in coordination chemistry and are widely used in a variety of fields. Metallic buildings have extra organic action than the relating ligands. Schiff base complexes in particular are particularly intriguing due to their stability, electron-donating potential, photochromic, optical nonlinearity properties, and biological interest. The coordination of Schiff bases with steel ions serves as the foundation for each one. With -NH2 and -COOH coordination sites, amino acids are functionally important in many biological processes and form Schiff bases that easily coordinate with metallic ions when combined with aldehydes or ketones. The majority of Schiff bases derived from amino acids and their metallic complexes exhibit specific pharmacological properties. This assess centers around research related with Schiff base buildings of amino corrosive subordinates throughout the course of recent years. We spotlight the antimicrobial, anticancer and cell reinforcement amino acids of a couple of Schiff base mixtures with nitrogen, oxygen and sulfur contributors and different metallic particles.
Published in | World Journal of Applied Chemistry (Volume 8, Issue 2) |
DOI | 10.11648/j.wjac.20230802.11 |
Page(s) | 22-33 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Schiff Base Complexes, Synthesis, Characterization, Biological Activity
[1] | Abu-Dief, A. M., & Mohamed, I. M. A. (2015). A review on versatile applications of transition metal complexes incorporating Schiff bases. Beni-Suef University Journal of Basic and Applied Sciences, 4 (2), 119–133. https://doi.org/10.1016/j.bjbas.2015.05.004 |
[2] | Mahmoud, W. H., Omar, M. M., Ahmed, Y. M., & Mohamed, G. G. (2020). Transition metal complexes of Schiff base ligand based on 4,6-diacetyl resorcinol. Applied Organometallic Chemistry, 34 (4), 1–20. https://doi.org/10.1002/aoc.5528 |
[3] | Prakash, A., Singh, B. K., Bhojak, N., & Adhikari, D. (2010). Synthesis and characterization of bioactive zinc(II) and cadmium(II) complexes with new Schiff bases derived from 4-nitrobenzaldehyde and acetophenone with ethylenediamine. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. https://doi.org/10.1016/j.saa.2010.03.019 |
[4] | Sakhare, D. T. (2020). Synthesis, Characterization of Schiff Bases and Biological Activities of Their Transition Metal Complexes-Review. International Journal of Advanced Science and Engineering. https://doi.org/10.29294/ijase.6.4.2020.1538-1544 |
[5] | Shoaib, K., Rehman, W., Mohammad, B., & Ali, S. (2013). Synthesis, characterization and biological applications of transition metal complexes of [no] donor schiff bases. Journal of Proteomics and Bioinformatics. https://doi.org/10.4172/jpb.1000274 |
[6] | W. Al Zoubi and Y. G. Ko, “Organometallic complexes of Schiff bases: Recent progress in oxidation catalysis,” Journal of Organometallic Chemistry. 2016. doi: 10.1016/j.jorganchem.2016.08.023. |
[7] | J. M. Mir, R. C. Maurya, D. K. Rajak, B. A. Malik, P. S. Jaget, and N. Jain, “A novel Schiff base complex of brain fuel (sugar) coordinated with intelligence mineral (Zn): Synthesis, conjoint DFT-experimental evaluation and super oxide dismutation,” Karbala Int. J. Mod. Sci., 2017, doi: 10.1016/j.kijoms.2017.05.003. |
[8] | K. Ghosh, K. Harms, and S. Chattopadhyay, “Synthesis, characterization and phenoxazinone synthase mimicking activity of cobalt(III) Schiff base complexes,” Polyhedron, 2017, doi: 10.1016/j.poly.2016.10.027. |
[9] | A. Ali, N. Abdullah, and M. J. Maah, “Synthesis, characterization and antioxidant studies on 4-phenyl-1,3,5- triazine-2,6-diamine Schiff bases and their nickel(II), copper(II) and zinc(II) complexes,” Asian J. Chem., 2013, doi: 2310.14233/ajchem.2013.13544. |
[10] | A. Prakash, B. K. Singh, N. Bhojak, and D. Adhikari, “Synthesis and characterization of bioactive zinc(II) and cadmium(II) complexes with new Schiff bases derived from 4-nitrobenzaldehyde and acetophenone with ethylenediamine,” Spectrochim. Acta -Part A Mol. Biomol. Spectrosc., 2010, doi: 10.1016/j.saa.2010.03.019. |
[11] | O. A. El-Gammal, A. A. El-Bindary, F. Sh. Mohamed, G. N. Rezk, and M. A. El-Bindary, “Synthesis, characterization, design, molecular docking, anti COVID-19 activity, DFT calculations of novel Schiff base with some transition metal complexes,” J. Mol. Liq., 2022, doi: 10.1016/j.molliq.2021.117850. |
[12] | A. M. Yimer, “Review on Preparation and Description of Some First Series Divalent Transition Metal Complexes with Novel Schiff’s Base Ligands,” Rev. Catal., 2015, doi: 10.18488/journal.96/2015.2.1/96.1.14.25. |
[13] | M. S. Gruzdev, U. V. Chervonova, A. A. Ksenofontov, M. A. Krestianinov, A. I. Alexandrov, and T. V. Pashkova, “Schiff base complexes with different metals incorporating derivatives of 3,6-di-tert-butylcarbazole,” Appl. Organomet. Chem., vol. 35, no. 4, pp. 1–11, 2021, doi: 10.1002/aoc.6145. |
[14] | W. H. Mahmoud, M. M. Omar, Y. M. Ahmed, and G. G. Mohamed, “Transition metal complexes of Schiff base ligand based on 4,6-diacetyl resorcinol,” Appl. Organomet. Chem., vol. 34, no. 4, pp. 1–20, 2020, doi: 10.1002/aoc.5528. |
[15] | P. S. Desai and D. V. Parekh, “c aciSynthesis, characterization and biological screening of novel metal(II) complexes of 2-{[2-(5-Benzoyl-1 H -benzotriazol-1-yl)-2-oxoethyl]amino}-5-bromobenzoid,” Asian J. Chem., 2021. |
[16] | D. R. Williams, “Metals, ligands, and cancer,” Chem. Rev., vol. 72, no. 3, pp. 203–213, 1972, doi: 10.1021/cr60277a001. |
[17] | S. Shahid, M. A. Raza, and Shafiq-Ur-Rehman, “Synthesis, characterization and antimicrobial potential of transition metal complexes of triacetic lactone,” African J. Biotechnol., 2009. |
[18] | D. T. Sakhare, “Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes,” in Current Advances in Chemistry and 24 Biochemistry Vol. 3, 2021. doi: 10.9734/bpi/cacb/v3/1574c. |
[19] | N. Raman, S. Ravichandran, and C. Thangaraja, “Copper(II), cobalt(II), nickel(II) and zinc(II) complexes of Schiff base derived from benzil-2,4-dinitrophenylhydrazone with aniline,” J. Chem. Sci., vol. 116, no. 4, pp. 215–219, 2004, doi: 10.1007/BF02708270. |
[20] | K. Mounika, A. Pragathi, and C. Gyanakumari, “Synthesis¸ Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes,” J. Sci. Res., 2010, doi: 10.3329/jsr.v2i3.4899. |
[21] | P. M. Reddy, “AZOMETHINE DERIVATIVE OF 2-AMINO-2-ETHYL-1, 3-PROPANEDIOL AND IT ’ S METAL COMPLEXES of Biomedical AND Pharmaceutical sciences,” no. January, 2021, doi: 10.17605/OSF.IO/SV69C. |
[22] | A. Mumtaz, T. Mahmud, M. R. J. Elsegood, G. W. Weaver, G. Bratu, and L. Mitu, “Synthesis, characterization and biological evaluation of schiff base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) ions,” Rev. Chim., 2020, doi: 10.37358/RC.20.1.7833. |
[23] | M. Shebl, O. M. I. Adly, E. M. Abdelrhman, and B. A. El-Shetary, “Binary and ternary copper(II) complexes of a new Schiff base ligand derived from 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone: Synthesis, spectral, thermal, antimicrobial and antitumor studies,” J. Mol. Struct., vol. 1145, pp. 329–338, 2017, doi: 10.1016/j.molstruc.2017.05.064. |
[24] | K. Ghosh et al., “Three mononuclear octahedral cobalt(III) complexes with salicylaldimine Schiff bases: Synthesis, characterization, phenoxazinone synthase mimicking activity and DFT study on supramolecular interactions,” Polyhedron, vol. 112, no. Iii, pp. 6–17, 2016, doi: 10.1016/j.poly.2016.02.035. |
[25] | A. Zülfikaroğlu, Ç. Yüksektepe Ataol, E. Çelikoğlu, U. Çelikoğlu, and Ö. İdil, “New Cu(II), Co(III) and Ni(II) metal complexes based on ONO donor tridentate hydrazone: Synthesis, structural characterization, and investigation of some biological properties,” J. Mol. Struct., 2020, doi: 10.1016/j.molstruc.2019.127012. |
[26] | G. B. Bagihalli and S. A. Patil, “Synthesis, physico-chemical investigations, and in 25 vitro microbial, studies of VO(IV) complexes with novel ONON donor Schiff bases,” Main Gr. Chem., vol. 8, no. 2, pp. 71–88, 2009, doi: 10.1080/10241220902977604. |
[27] | G. K. Sandhu and G. Kaur, “Preparation, IR and 1H NMR spectral studies of triorganotin(IV) complexes of N-benzoylglycine and N-benzoylglycylglycine,” J. Organomet. Chem., vol. 388, no. 1–2, pp. 63–70, 1990, doi: 10.1016/0022-328X(90)85347-2. |
[28] | A. S. Shekhawat, N. P. Singh, and N. S. Chundawat, “Synthesis, Characterization and Biological Activities of Schiff’s Base Metal Complexes Derived from Hydroxy Trizene and Aromatic Aldehyde,” J. Sci. Res, vol. 14, no. 1, pp. 387–394, 2022, [Online]. Available: http://dx.doi.org/10.3329/jsr.v14i1.54814 |
[29] | E. S. Freeman and B. Carroll, “The application of thermoanalytical techniques to reaction kinetics. The thermogravimetric evaluation of the kinetics of the decomposition of calcium oxalate monohydrate,” J. Phys. Chem., vol. 62, no. 4, pp. 394–397, 1958, doi: 10.1021/j150562a003. |
[30] | E. Banfi, G. Scialino, and C. Monti-Bragadin, “Development of a microdilution method to evaluate Mycobacterium tuberculosis drug susceptibility,” J. Antimicrob. Chemother., vol. 52, no. 5, pp. 796–800, 2003, doi: 10.1093/jac/dkg439. |
[31] | M. Balouiri, M. Sadiki, and S. K. Ibnsouda, “Methods for in vitro evaluating antimicrobial activity: A review,” J. Pharm. Anal., vol. 6, no. 2, pp. 71–79, 2016, doi: 10.1016/j.jpha.2015.11.005. |
[32] | J. E. Girard, Practical organic chemistry, vol. 284, no. 5751. 1980. doi: 10.1038/284083b0. |
[33] | “Solvent-free Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 2-Amino Benzimidazole with 4, 4’Dibromobenzil,” Lett. Appl. NanoBioScience, 2021, doi: 10.33263/lianbs113.38343842. |
[34] | A. M. Abu-Dief and I. M. A. Mohamed, “A review on versatile applications of transition metal complexes incorporating Schiff bases,” Beni-Suef Univ. J. Basic Appl. Sci., vol. 4, no. 2, pp. 119–133, 2015, doi: 10.1016/j.bjbas.2015.05.004. 26. |
[35] | E. L. Chang, C. Simmers, and D. A. Knight, “Cobalt complexes as antiviral and antibacterial agents,” Pharmaceuticals, vol. 3, no. 6, pp. 1711–1728, 2010, doi: 10.3390/ph3061711. |
[36] | P. A. Asbell, S. P. Epstein, J. A. Wallace, D. Epstein, C. C. Stewart, and R. M. Burger, “Efficacy of cobalt chelates in the rabbit eye model for epithelial herpetic keratitis,” Cornea, vol. 17, no. 5. pp. 550–557, 1998. doi: 10.1097/00003226-199809000-00014. |
[37] | J. A. Schwartz, E. K. Lium, and S. J. Silverstein, “Herpes Simplex Virus Type 1 Entry Is Inhibited by the Cobalt Chelate Complex CTC-96,” J. Virol., vol. 75, no. 9, pp. 4117–4128, 2001, doi: 10.1128/jvi.75.9.4117-4128.2001. |
[38] | A. Y. Louie and T. J. Meade, “A cobalt complex that selectively disrupts the structure and function of zinc fingers,” Proc. Natl. Acad. Sci. U. S. A., vol. 95, no. 12, pp. 6663–6668, 1998, doi: 10.1073/pnas.95.12.6663. |
[39] | D. Maity, “Biological Applications of Schiff Base and its Metal Complexes-A Review,” Int. J. Sci. Res., vol. 6, no. 2, pp. 471–478, 2019. |
[40] | R. K. Mehmood, “Review of cisplatin and oxaliplatin in current immunogenic and monoclonal antibodies perspective,” Oncol. Rev., vol. 8, no. 2, pp. 97–108, 2014, doi: 10.4081/oncol.2014.256. |
[41] | M. S. Karthikeyan, D. J. Prasad, B. Poojary, K. Subrahmanya Bhat, B. S. Holla, and N. S. Kumari, “Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety,” Bioorganic Med. Chem., vol. 14, no. 22, pp. 7482–7489, 2006, doi: 10.1016/j.bmc.2006.07.015. |
[42] | A. Echevarria, M. D. G. Nascimento, V. Gerônimo, J. Miller, and A. Giesbrecht, “NMR Spectroscopy, Hammett Correlations and Biological Activity of Some Schiff Bases Derived from Piperonal,” J. Braz. Chem. Soc., vol. 10, no. 1, pp. 60–64, 1999, doi: 10.1590/S0103-50531999000100010. |
[43] | A. Arunadevi and N. Raman, “Biological response of Schiff base metal complexes incorporating amino acids–a short review,” J. Coord. Chem., vol. 73, no. 15, pp. 2095–2116, 2020, doi: 10.1080/00958972.2020.1824293. |
[44] | M. S. Alam, J. H. Choi, and D. U. Lee, “Synthesis of novel Schiff base analogues of 4-27 amino-1,5-dimethyl-2- phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity,” Bioorganic Med. Chem., vol. 20, no. 13, pp. 4103–4108, 2012, doi: 10.1016/j.bmc.2012.04.058. |
[45] | M. Munjal, “Biological activity of transition metal complexes incorporating Schiff bases: A review,” vol. 6, no. 2, pp. 354–360, 2017. |
[46] | P. Rathelot et al., “Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity,” Eur. J. Med. Chem., vol. 30, no. 6, pp. 503–508, 1995, doi: 10.1016/0223-5234(96)88261-4. |
[47] | G. Bringmann et al., “Full Papers,” vol. 67, no. 5, pp. 5–10, 2004. |
[48] | A. B. Thomas, R. K. Nanda, L. P. Kothapalli, and S. C. Hamane, “Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents,” Arab. J. Chem., vol. 9, pp. S79–S90, 2016, doi: 10.1016/j.arabjc.2011.02.015. |
APA Style
Desalegn Tesfa Tefera. (2023). Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes. World Journal of Applied Chemistry, 8(2), 22-33. https://doi.org/10.11648/j.wjac.20230802.11
ACS Style
Desalegn Tesfa Tefera. Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes. World J. Appl. Chem. 2023, 8(2), 22-33. doi: 10.11648/j.wjac.20230802.11
AMA Style
Desalegn Tesfa Tefera. Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes. World J Appl Chem. 2023;8(2):22-33. doi: 10.11648/j.wjac.20230802.11
@article{10.11648/j.wjac.20230802.11, author = {Desalegn Tesfa Tefera}, title = {Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes}, journal = {World Journal of Applied Chemistry}, volume = {8}, number = {2}, pages = {22-33}, doi = {10.11648/j.wjac.20230802.11}, url = {https://doi.org/10.11648/j.wjac.20230802.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20230802.11}, abstract = {Schiff bases are aldehyde or ketone derivatives that are made by condensation of primary amines and carbonyl compounds and have their carbonyl organization (C = O) replaced by an imine or azomethine organization (>C = N-). Schiff bases are a key ligand elegance in coordination chemistry and are widely used in a variety of fields. Metallic buildings have extra organic action than the relating ligands. Schiff base complexes in particular are particularly intriguing due to their stability, electron-donating potential, photochromic, optical nonlinearity properties, and biological interest. The coordination of Schiff bases with steel ions serves as the foundation for each one. With -NH2 and -COOH coordination sites, amino acids are functionally important in many biological processes and form Schiff bases that easily coordinate with metallic ions when combined with aldehydes or ketones. The majority of Schiff bases derived from amino acids and their metallic complexes exhibit specific pharmacological properties. This assess centers around research related with Schiff base buildings of amino corrosive subordinates throughout the course of recent years. We spotlight the antimicrobial, anticancer and cell reinforcement amino acids of a couple of Schiff base mixtures with nitrogen, oxygen and sulfur contributors and different metallic particles.}, year = {2023} }
TY - JOUR T1 - Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes AU - Desalegn Tesfa Tefera Y1 - 2023/05/29 PY - 2023 N1 - https://doi.org/10.11648/j.wjac.20230802.11 DO - 10.11648/j.wjac.20230802.11 T2 - World Journal of Applied Chemistry JF - World Journal of Applied Chemistry JO - World Journal of Applied Chemistry SP - 22 EP - 33 PB - Science Publishing Group SN - 2637-5982 UR - https://doi.org/10.11648/j.wjac.20230802.11 AB - Schiff bases are aldehyde or ketone derivatives that are made by condensation of primary amines and carbonyl compounds and have their carbonyl organization (C = O) replaced by an imine or azomethine organization (>C = N-). Schiff bases are a key ligand elegance in coordination chemistry and are widely used in a variety of fields. Metallic buildings have extra organic action than the relating ligands. Schiff base complexes in particular are particularly intriguing due to their stability, electron-donating potential, photochromic, optical nonlinearity properties, and biological interest. The coordination of Schiff bases with steel ions serves as the foundation for each one. With -NH2 and -COOH coordination sites, amino acids are functionally important in many biological processes and form Schiff bases that easily coordinate with metallic ions when combined with aldehydes or ketones. The majority of Schiff bases derived from amino acids and their metallic complexes exhibit specific pharmacological properties. This assess centers around research related with Schiff base buildings of amino corrosive subordinates throughout the course of recent years. We spotlight the antimicrobial, anticancer and cell reinforcement amino acids of a couple of Schiff base mixtures with nitrogen, oxygen and sulfur contributors and different metallic particles. VL - 8 IS - 2 ER -