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Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria

Received: 8 July 2023     Accepted: 24 July 2023     Published: 5 August 2023
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Abstract

Background: Severe acute respiratory coronavirus-2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) is reportedly associated with acute renal injuries (AKI). However, this has been characterized majorly among Caucasians who have pre-existing confounding comorbidities that may also induce AKI, and hence, limit the conclusions of these previous studies. Consequently, the current study evaluated AKI incidence and associated factors among Nigerian COVID-19 patients of Negroid race who are without any pre-existing comorbid conditions. Methods: This was a retrospectively-designed observational study conducted among COVID-19 patients who presented at a COVID-19-designated treatment facility in Port Harcourt, Nigeria. Demographic, medical, and laboratory data obtained upon presentation were acquired and analyzed by AKI status using descriptive and inferential statistics. Results: Upon presentation, AKI occurred among 46.4% (n=181) of the entire studied population (n=390) which were majorly of stage 1, etiologically pre-renal, community-acquired, and of transient clinical course. Most of the AKI occurred among males, those with severe COVID-19 variants, and those who are unvaccinated against the disease. Those with COVID-19-associated AKI also had higher levels of peak plasma creatinine, plasma C-reactive protein, serum D-dimer, plasma osmolality, proteinuria, and hematuria but lower levels of within 24-hour urine volume, urine specific gravity, and urine osmolality compared to the non-AKI sub-group upon presentation. However, AKI patients with concurrent severe COVID-19 had a higher preponderance of stage 3, intra-renal and persistent AKI compared to patients with non-severe COVID-19 disease. In multivariate models, severe COVID-19 variant (OR: 6.017; CI: 5.880–6.422; p<0.001), the need for ICU transfer/treatment (OR: 3.210; CI: 3.119–3.341; p<0.001), serum D-dimer levels (OR: 3.967; CI: 3.688-4.297; p<0.001), and proteinuria (OR: 2.008; CI: 1.971–2.174; p=0.002) were independent risk factors for AKI among the studied population. Conclusion: AKI is common among COVID-19 patients independent of pre-existing comorbidities. The various COVID-19-associated AKI risk factors identified in the current study are valuable parameters that may guide clinical management among COVID-19 patients.

Published in World Journal of Medical Case Reports (Volume 4, Issue 3)
DOI 10.11648/j.wjmcr.20230403.12
Page(s) 35-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

COVID-19, COVID-19 Severity, COVID-19-Induced AKI

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Cite This Article
  • APA Style

    Ochuko Otokunefor, Collins Amadi, Kelachi Thankgod Wala, Emmanuel Mustapha Owamagbe, Bright Chike Amadi, et al. (2023). Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria. World Journal of Medical Case Reports, 4(3), 35-43. https://doi.org/10.11648/j.wjmcr.20230403.12

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    ACS Style

    Ochuko Otokunefor; Collins Amadi; Kelachi Thankgod Wala; Emmanuel Mustapha Owamagbe; Bright Chike Amadi, et al. Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria. World J. Med. Case Rep. 2023, 4(3), 35-43. doi: 10.11648/j.wjmcr.20230403.12

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    AMA Style

    Ochuko Otokunefor, Collins Amadi, Kelachi Thankgod Wala, Emmanuel Mustapha Owamagbe, Bright Chike Amadi, et al. Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria. World J Med Case Rep. 2023;4(3):35-43. doi: 10.11648/j.wjmcr.20230403.12

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  • @article{10.11648/j.wjmcr.20230403.12,
      author = {Ochuko Otokunefor and Collins Amadi and Kelachi Thankgod Wala and Emmanuel Mustapha Owamagbe and Bright Chike Amadi and Adekemi Layo Kiyesi and Chidozie Johnbosco Okafor and Ini John Ntuenibok},
      title = {Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria},
      journal = {World Journal of Medical Case Reports},
      volume = {4},
      number = {3},
      pages = {35-43},
      doi = {10.11648/j.wjmcr.20230403.12},
      url = {https://doi.org/10.11648/j.wjmcr.20230403.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20230403.12},
      abstract = {Background: Severe acute respiratory coronavirus-2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) is reportedly associated with acute renal injuries (AKI). However, this has been characterized majorly among Caucasians who have pre-existing confounding comorbidities that may also induce AKI, and hence, limit the conclusions of these previous studies. Consequently, the current study evaluated AKI incidence and associated factors among Nigerian COVID-19 patients of Negroid race who are without any pre-existing comorbid conditions. Methods: This was a retrospectively-designed observational study conducted among COVID-19 patients who presented at a COVID-19-designated treatment facility in Port Harcourt, Nigeria. Demographic, medical, and laboratory data obtained upon presentation were acquired and analyzed by AKI status using descriptive and inferential statistics. Results: Upon presentation, AKI occurred among 46.4% (n=181) of the entire studied population (n=390) which were majorly of stage 1, etiologically pre-renal, community-acquired, and of transient clinical course. Most of the AKI occurred among males, those with severe COVID-19 variants, and those who are unvaccinated against the disease. Those with COVID-19-associated AKI also had higher levels of peak plasma creatinine, plasma C-reactive protein, serum D-dimer, plasma osmolality, proteinuria, and hematuria but lower levels of within 24-hour urine volume, urine specific gravity, and urine osmolality compared to the non-AKI sub-group upon presentation. However, AKI patients with concurrent severe COVID-19 had a higher preponderance of stage 3, intra-renal and persistent AKI compared to patients with non-severe COVID-19 disease. In multivariate models, severe COVID-19 variant (OR: 6.017; CI: 5.880–6.422; p Conclusion: AKI is common among COVID-19 patients independent of pre-existing comorbidities. The various COVID-19-associated AKI risk factors identified in the current study are valuable parameters that may guide clinical management among COVID-19 patients.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Characteristics and Determinants of COVID-19-Associated AKI Among Patients of COVID-19 in Rivers State, Nigeria
    AU  - Ochuko Otokunefor
    AU  - Collins Amadi
    AU  - Kelachi Thankgod Wala
    AU  - Emmanuel Mustapha Owamagbe
    AU  - Bright Chike Amadi
    AU  - Adekemi Layo Kiyesi
    AU  - Chidozie Johnbosco Okafor
    AU  - Ini John Ntuenibok
    Y1  - 2023/08/05
    PY  - 2023
    N1  - https://doi.org/10.11648/j.wjmcr.20230403.12
    DO  - 10.11648/j.wjmcr.20230403.12
    T2  - World Journal of Medical Case Reports
    JF  - World Journal of Medical Case Reports
    JO  - World Journal of Medical Case Reports
    SP  - 35
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2994-726X
    UR  - https://doi.org/10.11648/j.wjmcr.20230403.12
    AB  - Background: Severe acute respiratory coronavirus-2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) is reportedly associated with acute renal injuries (AKI). However, this has been characterized majorly among Caucasians who have pre-existing confounding comorbidities that may also induce AKI, and hence, limit the conclusions of these previous studies. Consequently, the current study evaluated AKI incidence and associated factors among Nigerian COVID-19 patients of Negroid race who are without any pre-existing comorbid conditions. Methods: This was a retrospectively-designed observational study conducted among COVID-19 patients who presented at a COVID-19-designated treatment facility in Port Harcourt, Nigeria. Demographic, medical, and laboratory data obtained upon presentation were acquired and analyzed by AKI status using descriptive and inferential statistics. Results: Upon presentation, AKI occurred among 46.4% (n=181) of the entire studied population (n=390) which were majorly of stage 1, etiologically pre-renal, community-acquired, and of transient clinical course. Most of the AKI occurred among males, those with severe COVID-19 variants, and those who are unvaccinated against the disease. Those with COVID-19-associated AKI also had higher levels of peak plasma creatinine, plasma C-reactive protein, serum D-dimer, plasma osmolality, proteinuria, and hematuria but lower levels of within 24-hour urine volume, urine specific gravity, and urine osmolality compared to the non-AKI sub-group upon presentation. However, AKI patients with concurrent severe COVID-19 had a higher preponderance of stage 3, intra-renal and persistent AKI compared to patients with non-severe COVID-19 disease. In multivariate models, severe COVID-19 variant (OR: 6.017; CI: 5.880–6.422; p Conclusion: AKI is common among COVID-19 patients independent of pre-existing comorbidities. The various COVID-19-associated AKI risk factors identified in the current study are valuable parameters that may guide clinical management among COVID-19 patients.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Chemical Pathology, University of Port Harcourt, Port Harcourt, Nigeria

  • Department of Chemical Pathology, PAMO University of Medical Sciences, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University/Rivers State University Teaching Hospital, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University/Rivers State University Teaching Hospital, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University/Rivers State University Teaching Hospital, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University/Rivers State University Teaching Hospital, Port Harcourt, Nigeria

  • Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria

  • Department of Chemical Pathology, University of Uyo, Uyo, Nigeria

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