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Macular Hole Repair: Result of the Inverted Flap Technique-A Case Series

Received: 9 April 2025     Accepted: 19 April 2025     Published: 19 May 2025
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Abstract

Macular hole (MH) affects the central macula, causing visual impairment, metamorphopsia, and central scotoma. Vitrectomy with internal limiting membrane (ILM) peeling and tamponade is the standard treatment. The inverted ILM flap procedure is a newer surgical method that has shown promising anatomical results, particularly in large or chronic macular holes, by improving the rate of anatomical closure. This case series reports four patients with MH treated using vitrectomy with the inverted ILM flap technique using sulfur hexafluoride (SF6) gas tamponade. All patients presented with progressive central vision loss and were diagnosed via optical coherence tomography (OCT). Three of the four patients had a history of symptom duration exceeding three months, and one patient presented within one month of onset. Anatomical closure of the macular hole was achieved in all cases. One patient showed marked improvement in visual acuity, while the others exhibited limited functional recovery. Postoperative OCT imaging confirmed the closure of the defect in all patients. The visual outcomes appear to be influenced by factors such as the duration and size of the macular hole, as well as underlying ocular conditions. These findings highlight the importance of early diagnosis, timely surgical intervention, and patient education in optimizing outcomes for macular hole repair.

Published in World Journal of Medical Case Reports (Volume 6, Issue 2)
DOI 10.11648/j.wjmcr.20250602.11
Page(s) 10-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Macular Hole, Inverted ILM Flap, Pars Plana Vitrectomy, ILM Peeling, Case Series

References
[1] Ďurana MV, Vladimír Ď, Michal H, et al. Czech And Slovak Ophthalmology-Aop Comparison Of Techniques: Inverted Flap And Conventional Internal Limiting Membrane Removal In Idiopathic Macular Hole Surgery. 2024.
[2] Duker JS, Kaiser PK, Binder S, et al. The International Vitreomacular Traction Study Group Classification of Vitreomacular Adhesion, Traction, and Macular Hole. Ophthalmology 2013; 120: 2611-9.
[3] Robles-Holmes HK, Staropoli PC, Yannuzzi N, et al. Management of Large or Recurrent Macular Holes. Curr Ophthalmol Rep 2020; 8: 62-8.
[4] Wu T-T, Hou T-Y, Peng K-L, et al. Inverted flap technique versus internal limiting membrane insertion for macular hole in eyes with extremely high myopia. BMC Ophthalmol 2024; 24: 286.
[5] Kannan NB, Kohli P, Parida H, et al. Comparative study of inverted internal limiting membrane (ILM) flap and ILM peeling technique in large macular holes: a randomized-control trial. BMC Ophthalmol 2018; 18: 177.
[6] Shiode Y, Morizane Y, Matoba R, et al. The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure. Investigative Opthalmology & Visual Science 2017; 58: 4847.
[7] Manasa S, Kakkar P, Kumar A, et al. Comparative Evaluation of Standard ILM Peel With Inverted ILM Flap Technique In Large Macular Holes: A Prospective, Randomized Study. Ophthalmic Surg Lasers Imaging Retina 2018; 49: 236-40.
[8] Ota H, Kunikata H, Aizawa N, et al. Surgical results of internal limiting membrane flap inversion and internal limiting membrane peeling for macular hole. PLoS One 2018; 13: e0203789.
[9] Wu Y, Chen Y, Mao J, et al. Long-Term Quantitative Analysis of Inner Retinal Dimples and Visual Function Post Internal Limiting Membrane Peeling in Macular Diseases. Ophthalmol Ther 2024; 13: 221-36.
[10] Steel DH, Donachie PHJ, Aylward GW, et al. Factors affecting anatomical and visual outcome after macular hole surgery: findings from a large prospective UK cohort. Eye 2021; 35: 316-25.
[11] Essex RW, Hunyor AP, Moreno-Betancur M, et al. The Visual Outcomes of Macular Hole Surgery: A Registry-Based Study by the Australian and New Zealand Society of Retinal Specialists. Ophthalmol Retina 2018; 2: 1143-51.
[12] Baskaran P, Sindal MD, Ganne P, et al. Closure rate and recovery of subfoveal microstructures following conventional internal limiting membrane peeling versus per fluoro octane-assisted inverted flap for large macular holes-A randomized controlled trial (InFlap Study). Indian J Ophthalmol 2024; 72: S75-83.
[13] Hu Z, Xie P, Ding Y, et al. Face‐down or no face‐down posturing following macular hole surgery: a meta‐analysis. Acta Ophthalmol 2016; 94: 326-33.
Cite This Article
  • APA Style

    Reynaldo, Susetyo, P. B. (2025). Macular Hole Repair: Result of the Inverted Flap Technique-A Case Series. World Journal of Medical Case Reports, 6(2), 10-14. https://doi.org/10.11648/j.wjmcr.20250602.11

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    ACS Style

    Reynaldo; Susetyo, P. B. Macular Hole Repair: Result of the Inverted Flap Technique-A Case Series. World J. Med. Case Rep. 2025, 6(2), 10-14. doi: 10.11648/j.wjmcr.20250602.11

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    AMA Style

    Reynaldo, Susetyo PB. Macular Hole Repair: Result of the Inverted Flap Technique-A Case Series. World J Med Case Rep. 2025;6(2):10-14. doi: 10.11648/j.wjmcr.20250602.11

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  • @article{10.11648/j.wjmcr.20250602.11,
      author = {Reynaldo and Puranto Budi Susetyo},
      title = {Macular Hole Repair: Result of the Inverted Flap Technique-A Case Series
    },
      journal = {World Journal of Medical Case Reports},
      volume = {6},
      number = {2},
      pages = {10-14},
      doi = {10.11648/j.wjmcr.20250602.11},
      url = {https://doi.org/10.11648/j.wjmcr.20250602.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjmcr.20250602.11},
      abstract = {Macular hole (MH) affects the central macula, causing visual impairment, metamorphopsia, and central scotoma. Vitrectomy with internal limiting membrane (ILM) peeling and tamponade is the standard treatment. The inverted ILM flap procedure is a newer surgical method that has shown promising anatomical results, particularly in large or chronic macular holes, by improving the rate of anatomical closure. This case series reports four patients with MH treated using vitrectomy with the inverted ILM flap technique using sulfur hexafluoride (SF6) gas tamponade. All patients presented with progressive central vision loss and were diagnosed via optical coherence tomography (OCT). Three of the four patients had a history of symptom duration exceeding three months, and one patient presented within one month of onset. Anatomical closure of the macular hole was achieved in all cases. One patient showed marked improvement in visual acuity, while the others exhibited limited functional recovery. Postoperative OCT imaging confirmed the closure of the defect in all patients. The visual outcomes appear to be influenced by factors such as the duration and size of the macular hole, as well as underlying ocular conditions. These findings highlight the importance of early diagnosis, timely surgical intervention, and patient education in optimizing outcomes for macular hole repair.
    },
     year = {2025}
    }
    

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    T2  - World Journal of Medical Case Reports
    JF  - World Journal of Medical Case Reports
    JO  - World Journal of Medical Case Reports
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    AB  - Macular hole (MH) affects the central macula, causing visual impairment, metamorphopsia, and central scotoma. Vitrectomy with internal limiting membrane (ILM) peeling and tamponade is the standard treatment. The inverted ILM flap procedure is a newer surgical method that has shown promising anatomical results, particularly in large or chronic macular holes, by improving the rate of anatomical closure. This case series reports four patients with MH treated using vitrectomy with the inverted ILM flap technique using sulfur hexafluoride (SF6) gas tamponade. All patients presented with progressive central vision loss and were diagnosed via optical coherence tomography (OCT). Three of the four patients had a history of symptom duration exceeding three months, and one patient presented within one month of onset. Anatomical closure of the macular hole was achieved in all cases. One patient showed marked improvement in visual acuity, while the others exhibited limited functional recovery. Postoperative OCT imaging confirmed the closure of the defect in all patients. The visual outcomes appear to be influenced by factors such as the duration and size of the macular hole, as well as underlying ocular conditions. These findings highlight the importance of early diagnosis, timely surgical intervention, and patient education in optimizing outcomes for macular hole repair.
    
    VL  - 6
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