Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future.
| Published in | American Journal of Applied Scientific Research (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajasr.20230903.11 |
| Page(s) | 82-89 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ankylosing Spondylitis, Monocyte Subtype, Cytokines, Flow Cytometry
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APA Style
Miao Yu, Xiuli Tan. (2023). Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. American Journal of Applied Scientific Research, 9(3), 82-89. https://doi.org/10.11648/j.ajasr.20230903.11
ACS Style
Miao Yu; Xiuli Tan. Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. Am. J. Appl. Sci. Res. 2023, 9(3), 82-89. doi: 10.11648/j.ajasr.20230903.11
AMA Style
Miao Yu, Xiuli Tan. Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance. Am J Appl Sci Res. 2023;9(3):82-89. doi: 10.11648/j.ajasr.20230903.11
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Download@article{10.11648/j.ajasr.20230903.11,
author = {Miao Yu and Xiuli Tan},
title = {Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance},
journal = {American Journal of Applied Scientific Research},
volume = {9},
number = {3},
pages = {82-89},
doi = {10.11648/j.ajasr.20230903.11},
url = {https://doi.org/10.11648/j.ajasr.20230903.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajasr.20230903.11},
abstract = {Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future.},
year = {2023}
}
TY - JOUR T1 - Dynamic Changes of CD16+ Monocytes in Ankylosing Spondylitis and Its Significance AU - Miao Yu AU - Xiuli Tan Y1 - 2023/07/08 PY - 2023 N1 - https://doi.org/10.11648/j.ajasr.20230903.11 DO - 10.11648/j.ajasr.20230903.11 T2 - American Journal of Applied Scientific Research JF - American Journal of Applied Scientific Research JO - American Journal of Applied Scientific Research SP - 82 EP - 89 PB - Science Publishing Group SN - 2471-9730 UR - https://doi.org/10.11648/j.ajasr.20230903.11 AB - Background: The pathogenesis of ankylosing spondylitis (AS) is unclear and the incidence has been increasing in recent years. Objective: To explore the trend and clinical significance of peripheral blood mononuclear cell subtypes in patients with AS. Method: Detect plasma levels of seven cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-γ), analyze the correlation between the percentage of CD16+monocyte subtypes and cytokine expression at the same level. Result: Compared with the control group, the plasma levels of five cytokines in the AS group were significantly higher than those in the control group (P<0.05), and were positively correlated with the content of CD16+monocytes. Conclusion: CD16+monocytes are closely related to the occurrence of AS; Detecting CD16+monocyte subtypes in patients' peripheral blood can provide new experimental indicators for the diagnosis of AS. Taking AS as a starting point, it provides a new research direction for the treatment and prognosis detection of other autoimmune diseases in the future. VL - 9 IS - 3 ER -
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