Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products

Lei Wang; Luman Huo; Lixue Dong; Xuesong Wang; Litian Zhang; Ruihuan Du; Aijun Li; Yi Li

doi:doi:10.11648/j.ijaas.20220801.13

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Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products

Lei Wang, Luman Huo, Lixue Dong, Xuesong Wang, Litian Zhang, Ruihuan Du, Aijun Li, Yi Li

Published in International Journal of Applied Agricultural Sciences (Volume 8, Issue 1)

Received: 3 January 2022 Accepted: 14 January 2022 Published: 24 January 2022

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Abstract

Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. At present, the quality of milk and dairy products has become the core competitiveness of enterprises' future consumption and promotion, among which food additives and illegal additives, agricultural and veterinary drug residues, plasticizer and other exogenous risk substances are the focus of social attention. Therefore, it is of great practical significance and application value to establish the screening and analysis methods of exogenous risk substances in milk and dairy products. However, the ingredients of milk and dairy products are complex, and the exogenous risk substances are mostly small molecules, with low content and not easy to detect. Therefore, the instrument is required to have a very high selectivity and a super-high quality precision. Time-of-flight mass spectrometry is a high-resolution mass spectrometry, which can easily and quickly complete the rapid screening and identification of target compounds and unknown compounds, reduce the probability of "false positive" occurrence, and can analyze hundreds of compounds in a testing process, which can realize the accurate quantification and screening of veterinary drugs in milk. This paper mainly expounds the application of high-resolution mass spectrometry in exogenous risk material screening and adulterated substance analysis in milk and dairy products, and briefly analyzes its application prospects.

Published in	International Journal of Applied Agricultural Sciences (Volume 8, Issue 1)
DOI	10.11648/j.ijaas.20220801.13
Page(s)	20-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Milk and Dairy Products, High Resolution Time-of-flight Mass Spectrometry, Pesticide and Veterinary Drug Residues

References

[1]	ZHENG JH, PANG GF, FAN CL, et al. Simultaneous determination of 128 pesticide residues in milk by liquid chromatography-tandem electrospray mass spectrometry [J]. chinese Journal of Chromatography, 2009, 7 (03): 254-263. (in Chinese).
[2]	LIU Y, ZHENG GC, WANG J, et al. Determination of 20 organochlorine pesticides residues in milk by gas chromatography-tandem mass spectrometry [J]. Inspection and Quarantine Science, 2012, 22 (04): 38-45. (in Chinese).
[3]	MENG Z, SHI ZH, LYU YK, et al. Rapid Screening of fluoroquinolones and sulfonamides in dairy products using ultra performance liquid chromatography coupled to high resolution quadrupole time-of-flight mass spectrometry [J]. Chinese Journal of Analytical Chemistry, 2014, 42 (10): 1493-1500. (in Chinese).
[4]	HERNANDEZ F, PORTOLES T, IBANEZ M, et al. Use of time-of-flight mass spectrometry for large screening of organic pollutants in surface waters and soils from a rice production area in Colombia [J]. Science of the Total Environment, 2012, 432: 249-259.
[5]	WU YS, SUN DD, LI JG, et al. Survey on multiple pesticides residues in cow feed [J]. Food Safety and Quality Detection Technology, 2019, 010 (011): 3273-3279. (in Chinese).
[6]	LENG J, DENG B, LI QH, et al. Analysis of organophosphate pesticide residues in milk by gas chromatograph [J]. China Dairy Cattle, 2011 (02): 57-60. (in Chinese).
[7]	CHEN J, JIANG RQ, WEI WP, et al. Detection method of pesticide residues in raw milk by gas chromatography [J]. China Dairy Industry, 2013, 41 (011): 38-40. (in Chinese).
[8]	HAN JZ, TIAN XL, LI XZ, et al. Determination on 6 kinds of pesticide residues in the raw milk by ultra performance liquid chromatography-tandem mass spectrometry [C]// Liaoning Provincial Society of Animal Husbandry and Veterinary Medicine, 2014. (in Chinese).
[9]	DAI YY, YAN L, WANG CT, et al. Determination of organochlorine pesticide residues in fresh milk by gas chromatography-electron capture detector [J]. China Dairy, 2018, 204 (12): 66-68. (in Chinese).
[10]	LI H, DING JJ, LI JF. Source, harm and prevention and control of antibiotic residues in milk [J]. China Dairy, 2011, 2011 (008): 47-48. (in Chinese).
[11]	GONG SS, DU X, CAO H, et al. Rapid Screening of 14 Sulfonamides in Raw Milk by Ultra Performance Liquid Chromatography-Quadrupole Time-of-flight Mass Spectrometry [J]. Journal of Instrumental Analysis, 2014, 33 (012): 1342-1348. (in Chinese).
[12]	ZHANG J, YAN LQ, PAN CS, et al. Simultaneous analysis of 19 antibiotics in dairy products using ultra-performance liquid chromatography coupled with high resolution time-of-flight mass spectrometry [J]. Chinese Journal of Chromatography, 2012 (10): 1031-1036. (in Chinese).
[13]	PENG L, WU NP, ZHANG CW, et al. Screening Method for 55 Kinds of Drugs in Milk by Ultra Performance Liquid Chromatography-quadrupole Time-of-flight Mass Spectrometry [J]. Chinese Journal of Veterinary Drug, 2014 (9): 45-52. (in Chinese).
[14]	YU CH, LIN L, YANG JQ, et al. Rapid Screening of 28 Banned Veterinary Drugs in Milk by Ultra Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry [J]. Journal of Food Science and Biotechnology, 2017 (10): 62-68.
[15]	LI G, QI L, JIN BM, et al. Identification of adulteration and quality control of milk by UPLC/Q-TOF MS/MS [J]. Modern Preventive Medicine, 2016 (23). (in Chinese).

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APA Style

Lei Wang, Luman Huo, Lixue Dong, Xuesong Wang, Litian Zhang, et al. (2022). Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. International Journal of Applied Agricultural Sciences, 8(1), 20-23. https://doi.org/10.11648/j.ijaas.20220801.13

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ACS Style

Lei Wang; Luman Huo; Lixue Dong; Xuesong Wang; Litian Zhang, et al. Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. Int. J. Appl. Agric. Sci. 2022, 8(1), 20-23. doi: 10.11648/j.ijaas.20220801.13

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AMA Style

Lei Wang, Luman Huo, Lixue Dong, Xuesong Wang, Litian Zhang, et al. Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. Int J Appl Agric Sci. 2022;8(1):20-23. doi: 10.11648/j.ijaas.20220801.13

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@article{10.11648/j.ijaas.20220801.13,
  author = {Lei Wang and Luman Huo and Lixue Dong and Xuesong Wang and Litian Zhang and Ruihuan Du and Aijun Li and Yi Li},
  title = {Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products},
  journal = {International Journal of Applied Agricultural Sciences},
  volume = {8},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.ijaas.20220801.13},
  url = {https://doi.org/10.11648/j.ijaas.20220801.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijaas.20220801.13},
  abstract = {Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. At present, the quality of milk and dairy products has become the core competitiveness of enterprises' future consumption and promotion, among which food additives and illegal additives, agricultural and veterinary drug residues, plasticizer and other exogenous risk substances are the focus of social attention. Therefore, it is of great practical significance and application value to establish the screening and analysis methods of exogenous risk substances in milk and dairy products. However, the ingredients of milk and dairy products are complex, and the exogenous risk substances are mostly small molecules, with low content and not easy to detect. Therefore, the instrument is required to have a very high selectivity and a super-high quality precision. Time-of-flight mass spectrometry is a high-resolution mass spectrometry, which can easily and quickly complete the rapid screening and identification of target compounds and unknown compounds, reduce the probability of "false positive" occurrence, and can analyze hundreds of compounds in a testing process, which can realize the accurate quantification and screening of veterinary drugs in milk. This paper mainly expounds the application of high-resolution mass spectrometry in exogenous risk material screening and adulterated substance analysis in milk and dairy products, and briefly analyzes its application prospects.},
 year = {2022}
}

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TY  - JOUR
T1  - Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products
AU  - Lei Wang
AU  - Luman Huo
AU  - Lixue Dong
AU  - Xuesong Wang
AU  - Litian Zhang
AU  - Ruihuan Du
AU  - Aijun Li
AU  - Yi Li
Y1  - 2022/01/24
PY  - 2022
N1  - https://doi.org/10.11648/j.ijaas.20220801.13
DO  - 10.11648/j.ijaas.20220801.13
T2  - International Journal of Applied Agricultural Sciences
JF  - International Journal of Applied Agricultural Sciences
JO  - International Journal of Applied Agricultural Sciences
SP  - 20
EP  - 23
PB  - Science Publishing Group
SN  - 2469-7885
UR  - https://doi.org/10.11648/j.ijaas.20220801.13
AB  - Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. At present, the quality of milk and dairy products has become the core competitiveness of enterprises' future consumption and promotion, among which food additives and illegal additives, agricultural and veterinary drug residues, plasticizer and other exogenous risk substances are the focus of social attention. Therefore, it is of great practical significance and application value to establish the screening and analysis methods of exogenous risk substances in milk and dairy products. However, the ingredients of milk and dairy products are complex, and the exogenous risk substances are mostly small molecules, with low content and not easy to detect. Therefore, the instrument is required to have a very high selectivity and a super-high quality precision. Time-of-flight mass spectrometry is a high-resolution mass spectrometry, which can easily and quickly complete the rapid screening and identification of target compounds and unknown compounds, reduce the probability of "false positive" occurrence, and can analyze hundreds of compounds in a testing process, which can realize the accurate quantification and screening of veterinary drugs in milk. This paper mainly expounds the application of high-resolution mass spectrometry in exogenous risk material screening and adulterated substance analysis in milk and dairy products, and briefly analyzes its application prospects.
VL  - 8
IS  - 1
ER  -

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Author Information

Lei Wang

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Luman Huo

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Lixue Dong

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Xuesong Wang

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Litian Zhang

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Ruihuan Du

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Aijun Li

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China
Yi Li

Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan, China

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Plain Text BibTeX RIS

APA Style

Lei Wang, Luman Huo, Lixue Dong, Xuesong Wang, Litian Zhang, et al. (2022). Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. International Journal of Applied Agricultural Sciences, 8(1), 20-23. https://doi.org/10.11648/j.ijaas.20220801.13

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ACS Style

Lei Wang; Luman Huo; Lixue Dong; Xuesong Wang; Litian Zhang, et al. Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. Int. J. Appl. Agric. Sci. 2022, 8(1), 20-23. doi: 10.11648/j.ijaas.20220801.13

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AMA Style

Lei Wang, Luman Huo, Lixue Dong, Xuesong Wang, Litian Zhang, et al. Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products. Int J Appl Agric Sci. 2022;8(1):20-23. doi: 10.11648/j.ijaas.20220801.13

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@article{10.11648/j.ijaas.20220801.13,
  author = {Lei Wang and Luman Huo and Lixue Dong and Xuesong Wang and Litian Zhang and Ruihuan Du and Aijun Li and Yi Li},
  title = {Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products},
  journal = {International Journal of Applied Agricultural Sciences},
  volume = {8},
  number = {1},
  pages = {20-23},
  doi = {10.11648/j.ijaas.20220801.13},
  url = {https://doi.org/10.11648/j.ijaas.20220801.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijaas.20220801.13},
  abstract = {Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. At present, the quality of milk and dairy products has become the core competitiveness of enterprises' future consumption and promotion, among which food additives and illegal additives, agricultural and veterinary drug residues, plasticizer and other exogenous risk substances are the focus of social attention. Therefore, it is of great practical significance and application value to establish the screening and analysis methods of exogenous risk substances in milk and dairy products. However, the ingredients of milk and dairy products are complex, and the exogenous risk substances are mostly small molecules, with low content and not easy to detect. Therefore, the instrument is required to have a very high selectivity and a super-high quality precision. Time-of-flight mass spectrometry is a high-resolution mass spectrometry, which can easily and quickly complete the rapid screening and identification of target compounds and unknown compounds, reduce the probability of "false positive" occurrence, and can analyze hundreds of compounds in a testing process, which can realize the accurate quantification and screening of veterinary drugs in milk. This paper mainly expounds the application of high-resolution mass spectrometry in exogenous risk material screening and adulterated substance analysis in milk and dairy products, and briefly analyzes its application prospects.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Application of Liquid Chromatography-high Resolution Time-of-flight Mass Spectrometry in the Detection of Raw Milk and Dairy Products
AU  - Lei Wang
AU  - Luman Huo
AU  - Lixue Dong
AU  - Xuesong Wang
AU  - Litian Zhang
AU  - Ruihuan Du
AU  - Aijun Li
AU  - Yi Li
Y1  - 2022/01/24
PY  - 2022
N1  - https://doi.org/10.11648/j.ijaas.20220801.13
DO  - 10.11648/j.ijaas.20220801.13
T2  - International Journal of Applied Agricultural Sciences
JF  - International Journal of Applied Agricultural Sciences
JO  - International Journal of Applied Agricultural Sciences
SP  - 20
EP  - 23
PB  - Science Publishing Group
SN  - 2469-7885
UR  - https://doi.org/10.11648/j.ijaas.20220801.13
AB  - Milk and dairy products are more and more popular with consumers due to their various nutrients, and their quality and safety issues have always been concerned. At present, the quality of milk and dairy products has become the core competitiveness of enterprises' future consumption and promotion, among which food additives and illegal additives, agricultural and veterinary drug residues, plasticizer and other exogenous risk substances are the focus of social attention. Therefore, it is of great practical significance and application value to establish the screening and analysis methods of exogenous risk substances in milk and dairy products. However, the ingredients of milk and dairy products are complex, and the exogenous risk substances are mostly small molecules, with low content and not easy to detect. Therefore, the instrument is required to have a very high selectivity and a super-high quality precision. Time-of-flight mass spectrometry is a high-resolution mass spectrometry, which can easily and quickly complete the rapid screening and identification of target compounds and unknown compounds, reduce the probability of "false positive" occurrence, and can analyze hundreds of compounds in a testing process, which can realize the accurate quantification and screening of veterinary drugs in milk. This paper mainly expounds the application of high-resolution mass spectrometry in exogenous risk material screening and adulterated substance analysis in milk and dairy products, and briefly analyzes its application prospects.
VL  - 8
IS  - 1
ER  -

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