Gastroprotective Activity and Potential Mechanism of the Stem Bark of <i>Boswellia dalzielii</i> on Gastric Ulcer in Rat

Gustave Lebeau Ndji Otto; Adjia Hamadjida; Joel Hermann Taguemkam Sando; Loraine Sandrine Wega Youdom; Ludice Isabelle Golda Djouana Malefaa; Amang André Perfusion; Désirée Sandrine Essama Mbida; Jean Pierre Kilekoung Mingoas; Ernestine Nkwengoua Zodengoumba; Tan Paul Vernyuy

doi:doi:10.11648/j.jdmp.20230902.11

Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat

Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, Amang André Perfusion, Désirée Sandrine Essama Mbida, Jean Pierre Kilekoung Mingoas, Ernestine Nkwengoua Zodengoumba, Tan Paul Vernyuy

Published in Journal of Diseases and Medicinal Plants (Volume 9, Issue 2)

Received: 19 January 2023 Accepted: 14 February 2023 Published: 11 April 2023

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Abstract

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.

Published in	Journal of Diseases and Medicinal Plants (Volume 9, Issue 2)
DOI	10.11648/j.jdmp.20230902.11
Page(s)	33-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Medicinal Plant, Gastric Ulcer, Gastroprotection, Pyloric Ligation

References

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APA Style

Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. (2023). Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. Journal of Diseases and Medicinal Plants, 9(2), 33-39. https://doi.org/10.11648/j.jdmp.20230902.11

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ACS Style

Gustave Lebeau Ndji Otto; Adjia Hamadjida; Joel Hermann Taguemkam Sando; Loraine Sandrine Wega Youdom; Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J. Dis. Med. Plants 2023, 9(2), 33-39. doi: 10.11648/j.jdmp.20230902.11

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AMA Style

Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J Dis Med Plants. 2023;9(2):33-39. doi: 10.11648/j.jdmp.20230902.11

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@article{10.11648/j.jdmp.20230902.11,
  author = {Gustave Lebeau Ndji Otto and Adjia Hamadjida and Joel Hermann Taguemkam Sando and Loraine Sandrine Wega Youdom and Ludice Isabelle Golda Djouana Malefaa and Amang André Perfusion and Désirée Sandrine Essama Mbida and Jean Pierre Kilekoung Mingoas and Ernestine Nkwengoua Zodengoumba and Tan Paul Vernyuy},
  title = {Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {9},
  number = {2},
  pages = {33-39},
  doi = {10.11648/j.jdmp.20230902.11},
  url = {https://doi.org/10.11648/j.jdmp.20230902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20230902.11},
  abstract = {Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.},
 year = {2023}
}

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TY - JOUR
T1 - Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat
AU - Gustave Lebeau Ndji Otto
AU - Adjia Hamadjida
AU - Joel Hermann Taguemkam Sando
AU - Loraine Sandrine Wega Youdom
AU - Ludice Isabelle Golda Djouana Malefaa
AU - Amang André Perfusion
AU - Désirée Sandrine Essama Mbida
AU - Jean Pierre Kilekoung Mingoas
AU - Ernestine Nkwengoua Zodengoumba
AU - Tan Paul Vernyuy
Y1 - 2023/04/11
PY - 2023
N1 - https://doi.org/10.11648/j.jdmp.20230902.11
DO - 10.11648/j.jdmp.20230902.11
T2 - Journal of Diseases and Medicinal Plants
JF - Journal of Diseases and Medicinal Plants
JO - Journal of Diseases and Medicinal Plants
SP - 33
EP - 39
PB - Science Publishing Group
SN - 2469-8210
UR - https://doi.org/10.11648/j.jdmp.20230902.11
AB - Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.
VL - 9
IS - 2
ER -

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Author Information

Gustave Lebeau Ndji Otto

Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon
Adjia Hamadjida

Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon
Joel Hermann Taguemkam Sando

Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon
Loraine Sandrine Wega Youdom

Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon
Ludice Isabelle Golda Djouana Malefaa

Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon
Amang André Perfusion

Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua, Cameroon
Désirée Sandrine Essama Mbida

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
Jean Pierre Kilekoung Mingoas

School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Ernestine Nkwengoua Zodengoumba

Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
Tan Paul Vernyuy

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon

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APA Style

Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. (2023). Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. Journal of Diseases and Medicinal Plants, 9(2), 33-39. https://doi.org/10.11648/j.jdmp.20230902.11

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ACS Style

Gustave Lebeau Ndji Otto; Adjia Hamadjida; Joel Hermann Taguemkam Sando; Loraine Sandrine Wega Youdom; Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J. Dis. Med. Plants 2023, 9(2), 33-39. doi: 10.11648/j.jdmp.20230902.11

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AMA Style

Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J Dis Med Plants. 2023;9(2):33-39. doi: 10.11648/j.jdmp.20230902.11

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@article{10.11648/j.jdmp.20230902.11,
  author = {Gustave Lebeau Ndji Otto and Adjia Hamadjida and Joel Hermann Taguemkam Sando and Loraine Sandrine Wega Youdom and Ludice Isabelle Golda Djouana Malefaa and Amang André Perfusion and Désirée Sandrine Essama Mbida and Jean Pierre Kilekoung Mingoas and Ernestine Nkwengoua Zodengoumba and Tan Paul Vernyuy},
  title = {Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {9},
  number = {2},
  pages = {33-39},
  doi = {10.11648/j.jdmp.20230902.11},
  url = {https://doi.org/10.11648/j.jdmp.20230902.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20230902.11},
  abstract = {Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.},
 year = {2023}
}

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