Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat
Gustave Lebeau Ndji Otto,
Adjia Hamadjida,
Joel Hermann Taguemkam Sando,
Loraine Sandrine Wega Youdom,
Ludice Isabelle Golda Djouana Malefaa,
Amang André Perfusion,
Désirée Sandrine Essama Mbida,
Jean Pierre Kilekoung Mingoas,
Ernestine Nkwengoua Zodengoumba,
Tan Paul Vernyuy
Issue:
Volume 9, Issue 2, June 2023
Pages:
33-39
Received:
19 January 2023
Accepted:
14 February 2023
Published:
11 April 2023
Abstract: Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.
Abstract: Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalz...
Show More
Anti-Anemic Potential of a Herbal Recipe Against Phenylhydrazine-Induced Anemia in Rats
Tatiana Kangah Mireille Kple,
Joel Akakpo-Akue,
Konan Armand Marcelin Kouassi,
Sitapha Ouattara,
Gbe Kouakou N’Dri Ange Konan,
Diane Koulai,
Larissa Adjoua Kouadio,
Chiaye Claire Antoinette Yapo-Crezoit,
Adou Koffi Mattieu Kra,
Allico Joseph Djaman
Issue:
Volume 9, Issue 2, June 2023
Pages:
40-48
Received:
8 March 2023
Accepted:
6 April 2023
Published:
27 April 2023
Abstract: Anemia is characterized by an abnormal decrease in the level of hemoglobin or the number of red blood cells in the blood. It is a public health problem that mainly affects pregnant women and young children. In the present study, the objective was to evaluated the anti-anemic potential of a recipe composed of three medicinal plants, Xylopia aethiopica (Dunal) A. Rich, Zanthoxylum leprieurii (GUILL) and Harungara madagascariensis (LAM), used to treat sickle cell anemia in rats. Aqueous and hydroethanol extracts of recipe composed were first prepared and quantitative phytochemical tests were carried out. Then, the anti-anemic activity of the recipe extracts was assessed. The anemia was induced in animals by intraperitoneal injection of phenylhydrazine at a repeated dose of 40 mg/kg bw for two days. Treatment was carried out with the aqueous and hydroethanol extracts of the plant recipe at doses of 400 and 800 mg/kg bw. The obtained results indicated that recipe composed contains total phenols (43.31±0.92 mg GAE/g and 33.82±0.6 mg GAE /g of dry weight), total flavonoids (17.07±0.89 mg QE and 19.76±1.15 mg QE/g of dry weight) and total tannin (8.65±0.01 mg QE and 26.5±0.95 mg Cat E/g of dry weight) in decocted and hydroethanol extracts respectively. The anemia was effectively corrected after 21 days of oral administration of the extracts to the rats. The extracts significantly increased hemoglobin (P < 0.05), red blood cell count (P < 0.001), and hematocrit (P < 0.01) as early as the 7th days of treatment compared with untreated controls. These results show that the plant recipe composed of Xylopia aethiopica, Zanthoxylum leprieurii and Harungara madagascariensis possess antianemic properties.
Abstract: Anemia is characterized by an abnormal decrease in the level of hemoglobin or the number of red blood cells in the blood. It is a public health problem that mainly affects pregnant women and young children. In the present study, the objective was to evaluated the anti-anemic potential of a recipe composed of three medicinal plants, Xylopia aethiopi...
Show More
Antidiabetic, Toxicity Studies and Phytochemical Profile of Hedranthera barteri (Hook. f.) Pichon
Marcus Durojaye Ayoola,
Kingsley Onyekachi Ngwu,
Oluwaseun Alimot Kareem,
Khadijah Adewunmi,
Oluwabusayo Emmanuel Kasumu,
Akintunde Samuel Odediran,
Farouk Adedeji Oladoja,
Katherine Olabanjo Olufolabo,
Adediwura Fred-Jaiyesimi
Issue:
Volume 9, Issue 2, June 2023
Pages:
49-59
Received:
23 April 2023
Accepted:
17 May 2023
Published:
29 June 2023
Abstract: Objective: This work investigated the antihyperglycaemic activities, safety and chemical composition of Hedranthera barteri (Hook. f.) Pichon (Apocynaceae) methanol leaf extract aimed at establishing its antidiabetic folkloric usage. Methods: Acute and sub acute toxicity tests of the plant extract were assessed with a modified OECD test guidelines. The effects of the extract on glucose, haematological and biochemical parameters were evaluated using standard procedures. Its antidiabetic activities were assayed in α-amylase, α-glucosidase, glucose and streptozotocin-induced diabetic rats’ models at various doses with acarbose and glibenclamide (5 mg/kg) as positive controls. Histopathological examination of the pancreas, liver and kidney of rats administered with the extract at 250, 500 and 1000 mg/kg was also carried out. The phytochemical components of the extract were analysed with GC-MS. The results obtained from these studies were subjected to statistical analysis using Analysis of Variance (ANOVA), followed by the Student Newman Keul's test, and p< 0.05 was taken as significant. Results: The median lethal dose, LD50 of the extract was above 5000 mg/kg in rats without adverse effects on blood glucose levels and biochemical components of normal rats especially at 250 and 500 mg/kg while it significantly potentiated PCV, RBC and haemoglobin levels of the rats. The extract caused an inhibition of α-amylase and α-glucosidase enzymes in concentration dependent manner, reduced hyperglycaemia in glucose loaded rats with 200 mg/kg as the most effective dose and elicited hyperglycaemia lowering activity that was comparable to glibenclamide in drug-induced diabetic rats. The extract had no adverse effect on the histology of the pancreas, liver and kidney at 250 mg/kg while 500 and 1000 mg/kg caused moderate and severe effects on these organs, respectively. Tannins, flavonoids, saponins, alkaloids, terpenoids, deoxy-sugars were observed in the extract by preliminary phytochemical screening while some GC-MS identified possible antidiabetic constituents of the plant include 9, 12-Octadecadinoic acid, phytol and catechol. Conclusion: The study validated the folkloric use of the leaves of Hedranthera barteri in the management of diabetes mellitus and confirmed its non toxic effect on different blood components of animals and their organs at low doses.
Abstract: Objective: This work investigated the antihyperglycaemic activities, safety and chemical composition of Hedranthera barteri (Hook. f.) Pichon (Apocynaceae) methanol leaf extract aimed at establishing its antidiabetic folkloric usage. Methods: Acute and sub acute toxicity tests of the plant extract were assessed with a modified OECD test guidelines....
Show More
