Toxicological Evaluation of Sleep Well Capsule

Chen Jiejun; Li Ruipeng; Guo Qiuping

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Toxicological Evaluation of Sleep Well Capsule

Chen Jiejun, Li Ruipeng, Guo Qiuping

Published in Asia-Pacific Journal of Food Science and Technology (Volume 1, Issue 1)

Received: 9 November 2018 Accepted: 6 January 2019 Published: 1 February 2019

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Abstract

Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.

Published in	Asia-Pacific Journal of Food Science and Technology (Volume 1, Issue 1)
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Capsule, Genotoxicity, Toxicological Evaluation

References

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APA Style

Chen Jiejun, Li Ruipeng, Guo Qiuping. (2019). Toxicological Evaluation of Sleep Well Capsule. Asia-Pacific Journal of Food Science and Technology, 1(1), 1-6.

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ACS Style

Chen Jiejun; Li Ruipeng; Guo Qiuping. Toxicological Evaluation of Sleep Well Capsule. Asia-Pac. J. Food Sci. Technol. 2019, 1(1), 1-6.

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AMA Style

Chen Jiejun, Li Ruipeng, Guo Qiuping. Toxicological Evaluation of Sleep Well Capsule. Asia-Pac J Food Sci Technol. 2019;1(1):1-6.

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@article{10035051,
  author = {Chen Jiejun and Li Ruipeng and Guo Qiuping},
  title = {Toxicological Evaluation of Sleep Well Capsule},
  journal = {Asia-Pacific Journal of Food Science and Technology},
  volume = {1},
  number = {1},
  pages = {1-6},
  url = {https://www.sciencepublishinggroup.com/article/10035051},
  abstract = {Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.},
 year = {2019}
}

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TY  - JOUR
T1  - Toxicological Evaluation of Sleep Well Capsule
AU  - Chen Jiejun
AU  - Li Ruipeng
AU  - Guo Qiuping
Y1  - 2019/02/01
PY  - 2019
T2  - Asia-Pacific Journal of Food Science and Technology
JF  - Asia-Pacific Journal of Food Science and Technology
JO  - Asia-Pacific Journal of Food Science and Technology
SP  - 1
EP  - 6
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10035051
AB  - Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.
VL  - 1
IS  - 1
ER  -

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Author Information

Chen Jiejun

Drug Nonclinical Evaluation and Research Centre of Guangzhou Pharmaceutical Research Institute, Guangzhou, China
Li Ruipeng

Drug Nonclinical Evaluation and Research Centre of Guangzhou Pharmaceutical Research Institute, Guangzhou, China
Guo Qiuping

Drug Nonclinical Evaluation and Research Centre of Guangzhou Pharmaceutical Research Institute, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Chen Jiejun, Li Ruipeng, Guo Qiuping. (2019). Toxicological Evaluation of Sleep Well Capsule. Asia-Pacific Journal of Food Science and Technology, 1(1), 1-6.

Copy | Download

ACS Style

Chen Jiejun; Li Ruipeng; Guo Qiuping. Toxicological Evaluation of Sleep Well Capsule. Asia-Pac. J. Food Sci. Technol. 2019, 1(1), 1-6.

Copy | Download

AMA Style

Chen Jiejun, Li Ruipeng, Guo Qiuping. Toxicological Evaluation of Sleep Well Capsule. Asia-Pac J Food Sci Technol. 2019;1(1):1-6.

Copy | Download

@article{10035051,
  author = {Chen Jiejun and Li Ruipeng and Guo Qiuping},
  title = {Toxicological Evaluation of Sleep Well Capsule},
  journal = {Asia-Pacific Journal of Food Science and Technology},
  volume = {1},
  number = {1},
  pages = {1-6},
  url = {https://www.sciencepublishinggroup.com/article/10035051},
  abstract = {Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Toxicological Evaluation of Sleep Well Capsule
AU  - Chen Jiejun
AU  - Li Ruipeng
AU  - Guo Qiuping
Y1  - 2019/02/01
PY  - 2019
T2  - Asia-Pacific Journal of Food Science and Technology
JF  - Asia-Pacific Journal of Food Science and Technology
JO  - Asia-Pacific Journal of Food Science and Technology
SP  - 1
EP  - 6
PB  - Science Publishing Group
UR  - http://www.sciencepg.com/article/10035051
AB  - Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.
VL  - 1
IS  - 1
ER  -

Copy | Download