Antioxidant and Antiobesogenic Properties of Aqueous Extracts of Hibiscus sabdariffa, Zingiber officinale and Mentha spicata in Wistar High-Fat Diet Rats
Nkepndep Touohou Suzie Vanissa,
Dongho Dongmo Fabrice Fabien,
Lienou Lienou Landry,
Maffo Tazoho Ghislain,
Djeukeu Assongni William,
Manz Koule Jules Christophe,
Bogning Zangueu Calvin,
Mbiatat Hilaire De Goeithe,
Ebelle Etame Rebecca Madeleine,
Gouado Inocent
Issue:
Volume 10, Issue 5, September 2022
Pages:
151-164
Received:
11 August 2022
Accepted:
15 September 2022
Published:
28 September 2022
DOI:
10.11648/j.jfns.20221005.11
Downloads:
Views:
Abstract: The world has already undergone several health-related upheavals that have drawn the attention among which obesity. It is an important public health problem as well in developed as in developing countries. In order to sustainably manage this disease and associated damages, medicinal plants could be an alternative solution to synthetic drugs which can present side effects. Thus, the present study aimed at screening In vitro and In vivo antioxidant and antiobesogenic properties of aqueous extracts of some local plant resources of Cameroon including Hibiscus sabdariffa calyces, Zingiber officinale rhizomes and Mentha spicata leaves. A phytochemical screening was performed on the aqueous extracts of the plants, and their In vitro antioxidant activity evaluated. In vivo antioxidant and antiobesogenic activities were assessed on male Wistar rats. ‘Cafeteria’ diet was used as obesity-inducer and Orlistat as standard treatment. Through the experiment, the extracts were orally administered at 1 g/kg bw per day for 28 days. In vivo antioxidant activity consisted of the evaluation of lipid peroxidation and some enzymes in serum, liver and kidneys. Antiobesogenic properties consisted of determining anthropometric parameters, food consumption pattern, blood lipids profile and glucose content. Hepatic and renal functions were also examined. The screening revealed numerous groups of bioactive compounds in the three tested extracts which also showed reasonable total phenolic content (338.67-1141.12 mgGAE/100g). They revealed excellent antioxidant activity through their good free radical DPPH scavenging potential, reducing power activity, significant decrease of tissue malondialdehyde content and increase of superoxide dismutase and catalase activities. Furthermore, they revealed antiobesogenic effect by their induction of significant reduction (p < 0.05) in body mass index, adipose tissue, food intake, blood contents of triglycerides, total cholesterol, LDL-cholesterol, glucose and atherogenic index, while increasing HDL-cholesterol, all compared to untreated obese animals. They exhibited a relatively protective effect on hepatic and renal functions by remedying histopathological damages caused by high-fat diet and by reducing blood transaminases activity, creatinine and urea contents. These effects were comparable or even greater than those observed with Orlistat. The findings of the present research showed that the three plants could be used in the management of obesity and oxidative stress.
Abstract: The world has already undergone several health-related upheavals that have drawn the attention among which obesity. It is an important public health problem as well in developed as in developing countries. In order to sustainably manage this disease and associated damages, medicinal plants could be an alternative solution to synthetic drugs which c...
Show More
Assessing the Efficacy of a Nutritional Intervention Program in a Tribal Area in Maharashtra
Issue:
Volume 10, Issue 5, September 2022
Pages:
165-170
Received:
15 September 2022
Accepted:
4 October 2022
Published:
24 October 2022
DOI:
10.11648/j.jfns.20221005.12
Downloads:
Views:
Abstract: Nutritional deficiency is a key impediment to the development of India as it impacts the growth, health and productivity of its population. The government has sponsored a Midday Meal Scheme (“MMS”), a school meal program to improve the nutritional standing of children in the country. MMS currently serves approximately 120 million children in over 1.27 million schools and is the largest such program in the world. While MMS is far reaching and has the best of intentions its effectiveness in pre-primary and primary children is limited. The Bombay Mothers and Child Welfare Society (“BMCWS”) a 100 year old social organization based out of Mumbai had introduced a nutrition support program in the form of a breakfast meal (“BMCWS Meal Plan”) to address this deficiency in 2018. This study is designed to assess the efficacy of the BMCWS Meal Plan to serve as a supplement to the MMS in Rajgurunagar taluka, a tribal belt in Pune district, Maharashtra India.. The anthropometric indicators data collected is based on reporting guidelines of the Technical Expert Advisory Group on Nutrition Monitoring (TEAM) of UNICEF-WHO. Local school teachers collaborated to collect age, weight and height data for 159 children across 16 different schools in remote locations. Similarly hemoglobin readings of the children were taken with qualified nursing staff and the sample set was divided into three control groups. There was a clear improvement in the hemoglobin readings of the children in the program which implies the plan is effective in preventing anemia in children. Overall the results of the nutritional program show that it is not effective on anthropometric parameters however there is a positive impact on hemoglobin readings. Some changes to the existing nutrition plan will have a more pronounced impact on the children, specifically the introduction of pre-boiled eggs which will increase the protein intake in the diet and also be easy to transport to remote locations by the teachers.
Abstract: Nutritional deficiency is a key impediment to the development of India as it impacts the growth, health and productivity of its population. The government has sponsored a Midday Meal Scheme (“MMS”), a school meal program to improve the nutritional standing of children in the country. MMS currently serves approximately 120 million children in over 1...
Show More
