Tissue-engineered scaffolds are one of the effective methods for the treatment of bone defects, whose structure and function are essential for bone regeneration. Digital light processing (DLP) printing technology has been widely used in bone tissue engineering (BTE) for its high printing resolution and gentle printing process. Synthetic polymers, one of the commonly used bio-inks, with satisfactory printability and mechanical properties, usually lack sufficient adhesion to cells and tissues. Here, a BTE scaffold with composite composition is successfully prepared by DLP printing technology. Not only can the scaffold facilitate the adhesion and proliferation of cells, but also effectively promote the osteogenic differentiation of mesenchymal stem cells in an osteoinductive environment. Moreover, the scaffold in vivo guide new bone growth towards the interior of the defect. Therefore, the composite scaffold prepared by DLP printing technology provides a new approach to the clinical treatment of bone defects.

Biomaterials, Digital Light Processing, Bone Tissue Engineering, Bone Regeneration