A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions

Alexey Gareev

doi:doi:10.11648/j.ajhr.20261405.13

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A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions

Alexey Gareev^*

Published in American Journal of Health Research (Volume 14, Issue 5)

Received: 3 August 2026 Accepted: 17 August 2026 Published: 27 September 2026

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Abstract

This review proposes assessing the animal organism, its state of life, health, and response to external factors from the perspective of ontological constructivism, attempting to analyze the best-known, and thus accessible, components of the biological life process. The evolution of responses is examined in a sequence of stages termed by the author "natural lavage with mucosal secretions," "pre-inflammation," and then aseptic inflammation and antigen-dependent inflammation. Emphasis is placed on the fact that the immune system is a unified structure that interacts with antigens of both infectious and non-infectious origins according to a single algorithm. This supports the pathophysiological concept of inflammation as a typical, universal response of the body to exposure to a phlogogen of any origin, thereby substantiating the assertion that allergy is a particular manifestation of inflammation as a syndrome. A critical assessment is given to the current understanding of allergy pathogenesis, which distorts the cause-and-effect relationships in the sequence of processes that form the disease picture. A proposal has been put forward to consider biochemical reactions occurring on mucous membranes and skin within the microbiome's environment as neutralizing the antigenic properties of external protein structures through enzymatic breakdown into low-molecular-weight products. These products, upon penetrating the internal environment, lose their ability to trigger an inflammatory response involving the immune system. The duality of inflammation, in which localized and generalized forms are combined, is considered as a morphologically justified manifestation of opposing protective and destructive effects on the microorganism.

Published in	American Journal of Health Research (Volume 14, Issue 5)
DOI	10.11648/j.ajhr.20261405.13
Page(s)	242-254
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Ontological Constructivism, Phylogeny Inflammation, Сo-occurrence of Allergy and Inflammation. Selective Fermentopathy, Inflammation Dualism

References

[1]	Imai S. An onion enzyme that makes the eyes water. Nature. 2002; 419(6908): 685. https://doi.org/10.1038/419685a
[2]	Block E. Garlic and Other Alliums: The Lore and the Science. Royal Society of Chemistry; 2010. 432 p. https://doi.org/10.2307/41242898
[3]	Prausnitz C, Küstner H. Studien über die Ueberempfindlichkeit. Zentralbl Bakteriol. 1921; 86: 160-169.
[4]	Ishizaka K, Ishizaka T. Immunology of IgE mediated hypersensitivity. In: Allergy: Principles and Practice. 2nd ed. St. Louis: Mosby; 1983: 52.
[5]	Wisniewski J, Agrawal R, Woodfolk J. Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin Exp Allergy. 2013; 43(2): 164-176. https://doi.org/10.1111/cea.12016
[6]	Billingham R, Brent L, Medawar P. ‘Actively acquired tolerance’ of foreign cells. Transplantation. 2003; 76(10): 1409-1412. https://doi.org/10.1097/01.TP.0000102675.72061.88
[7]	Ivanov LN, Ulyanova IN, Kolotilova ML. Types of exogenous allergens. Medicus. 2021; (2): 38. (In Russ.)
[8]	Schreiber J, Bröker B, Ehmann R, Bachert C. Nonatopic severe asthma might still be atopic: Sensitization toward Staphylococcus aureus enterotoxins. J Allergy Clin Immunol. 2019; 143(6): 2279-2280. e2. https://doi.org/10.1016/j.jaci.2019.02.012
[9]	Bachert C, Humbert M, Hanania N. Staphylococcus aureus and its IgE-inducing enterotoxins in asthma. Eur Respir J. 2020; 55(4): 1901592. https://doi.org/10.1183/13993003.01592-2019
[10]	Hozumi N, Tonegawa S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci U S A. 1976; 73(10): 3628-3632. https://doi.org/10.1073/pnas.73.10.3628
[11]	Krebs J, Goldstein E, Kilpatrick S. Lewin's GENES X. 10th ed. Jones & Bartlett Learning; 2011. [Russ. ed.: Laboratory of Knowledge; 2017. 919 p].
[12]	Gareev A. The determining role of the microbiome in the pathogenesis of allergic diseases. Prospects for personalized laboratory diagnostics and therapy. Immunology and Allergy: Science and Practice. 2021; (4): 46-57. https://doi.org/10.37321/immunology.2021.4-05 (In Ukr.).
[13]	Sutton B J, Davies A M. Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII. Immunol Rev. 2015; 268(1): 222-235. https://doi.org/10.1111/imr.12340
[14]	Bruhns P, Jonsson F. Mouse and human FcR effector functions. Immunol Rev. 2015; 268(1): 25-51. https://doi.org/10.1111/imr.12350
[15]	Kraft S, Kinet J P. New developments in FcεRI regulation, function and inhibition. Nat Rev Immunol. 2007; 7(5): 365-378. https://doi.org/10.1038/nri2072
[16]	Semper A, Heron K, Woollard A. Surface expression of FcεRI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis. J Allergy Clin Immunol. 2003; 112(2): 411-419. https://doi.org/10.1016/s0091-6749(03)01557-4
[17]	Redhu N S, Gounni A S. The high affinity IgE receptor (FcεRI) expression and function in airway smooth muscle. Pulm Pharmacol Ther. 2013; 26(1): 86-94. https://doi.org/10.1016/j.pupt.2012.04.004
[18]	Domingo C, Busse W, Hanania N, et al. The direct and indirect role of IgE on airway epithelium in asthma. Allergy. Published online February 18, 2025. https://doi.org/10.1111/all.16459
[19]	Serebryanaya N B, Shanin S N, Fomicheva E E, Yakutseni P P. Platelets as activators and regulators of inflammatory and immune reactions. Part 2. Platelets as participants in immune reactions. Med Immunol (Russia). 2019; 21(1): 9-20. https://doi.org/10.15789/1563-0625-2019-1-9-20 (In Russ.).
[20]	Li H, Deng Y, Li Z, et al. Multiphysics and multiscale modeling of microthrombosis in COVID-19. PLoS Comput Biol. 2022; 18(3): e1009892. https://doi.org/10.1371/journal.pcbi.1009892
[21]	Talaeva TV. Mechanisms of interaction between blood cells and the vascular wall in the implementation of inflammatory and immune responses. Ukr Rheumatol J. 2001;(3-4): 5-6. (In Ukr.).

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APA Style

Gareev, A. (2026). A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. American Journal of Health Research, 14(5), 242-254. https://doi.org/10.11648/j.ajhr.20261405.13

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ACS Style

Gareev, A. A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. Am. J. Health Res. 2026, 14(5), 242-254. doi: 10.11648/j.ajhr.20261405.13

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AMA Style

Gareev A. A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. Am J Health Res. 2026;14(5):242-254. doi: 10.11648/j.ajhr.20261405.13

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@article{10.11648/j.ajhr.20261405.13,
  author = {Alexey Gareev},
  title = {A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions},
  journal = {American Journal of Health Research},
  volume = {14},
  number = {5},
  pages = {242-254},
  doi = {10.11648/j.ajhr.20261405.13},
  url = {https://doi.org/10.11648/j.ajhr.20261405.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20261405.13},
  abstract = {This review proposes assessing the animal organism, its state of life, health, and response to external factors from the perspective of ontological constructivism, attempting to analyze the best-known, and thus accessible, components of the biological life process. The evolution of responses is examined in a sequence of stages termed by the author "natural lavage with mucosal secretions," "pre-inflammation," and then aseptic inflammation and antigen-dependent inflammation. Emphasis is placed on the fact that the immune system is a unified structure that interacts with antigens of both infectious and non-infectious origins according to a single algorithm. This supports the pathophysiological concept of inflammation as a typical, universal response of the body to exposure to a phlogogen of any origin, thereby substantiating the assertion that allergy is a particular manifestation of inflammation as a syndrome. A critical assessment is given to the current understanding of allergy pathogenesis, which distorts the cause-and-effect relationships in the sequence of processes that form the disease picture. A proposal has been put forward to consider biochemical reactions occurring on mucous membranes and skin within the microbiome's environment as neutralizing the antigenic properties of external protein structures through enzymatic breakdown into low-molecular-weight products. These products, upon penetrating the internal environment, lose their ability to trigger an inflammatory response involving the immune system. The duality of inflammation, in which localized and generalized forms are combined, is considered as a morphologically justified manifestation of opposing protective and destructive effects on the microorganism.},
 year = {2026}
}

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TY  - JOUR
T1  - A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions
AU  - Alexey Gareev
Y1  - 2026/09/27
PY  - 2026
N1  - https://doi.org/10.11648/j.ajhr.20261405.13
DO  - 10.11648/j.ajhr.20261405.13
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 242
EP  - 254
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20261405.13
AB  - This review proposes assessing the animal organism, its state of life, health, and response to external factors from the perspective of ontological constructivism, attempting to analyze the best-known, and thus accessible, components of the biological life process. The evolution of responses is examined in a sequence of stages termed by the author "natural lavage with mucosal secretions," "pre-inflammation," and then aseptic inflammation and antigen-dependent inflammation. Emphasis is placed on the fact that the immune system is a unified structure that interacts with antigens of both infectious and non-infectious origins according to a single algorithm. This supports the pathophysiological concept of inflammation as a typical, universal response of the body to exposure to a phlogogen of any origin, thereby substantiating the assertion that allergy is a particular manifestation of inflammation as a syndrome. A critical assessment is given to the current understanding of allergy pathogenesis, which distorts the cause-and-effect relationships in the sequence of processes that form the disease picture. A proposal has been put forward to consider biochemical reactions occurring on mucous membranes and skin within the microbiome's environment as neutralizing the antigenic properties of external protein structures through enzymatic breakdown into low-molecular-weight products. These products, upon penetrating the internal environment, lose their ability to trigger an inflammatory response involving the immune system. The duality of inflammation, in which localized and generalized forms are combined, is considered as a morphologically justified manifestation of opposing protective and destructive effects on the microorganism.
VL  - 14
IS  - 5
ER  -

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Author Information

Alexey Gareev

Simesta Company, Odessa, Ukraine

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http://orcid.org/0000-0002-6355-2668

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APA Style

Gareev, A. (2026). A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. American Journal of Health Research, 14(5), 242-254. https://doi.org/10.11648/j.ajhr.20261405.13

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ACS Style

Gareev, A. A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. Am. J. Health Res. 2026, 14(5), 242-254. doi: 10.11648/j.ajhr.20261405.13

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AMA Style

Gareev A. A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions. Am J Health Res. 2026;14(5):242-254. doi: 10.11648/j.ajhr.20261405.13

Copy | Download

@article{10.11648/j.ajhr.20261405.13,
  author = {Alexey Gareev},
  title = {A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions},
  journal = {American Journal of Health Research},
  volume = {14},
  number = {5},
  pages = {242-254},
  doi = {10.11648/j.ajhr.20261405.13},
  url = {https://doi.org/10.11648/j.ajhr.20261405.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20261405.13},
  abstract = {This review proposes assessing the animal organism, its state of life, health, and response to external factors from the perspective of ontological constructivism, attempting to analyze the best-known, and thus accessible, components of the biological life process. The evolution of responses is examined in a sequence of stages termed by the author "natural lavage with mucosal secretions," "pre-inflammation," and then aseptic inflammation and antigen-dependent inflammation. Emphasis is placed on the fact that the immune system is a unified structure that interacts with antigens of both infectious and non-infectious origins according to a single algorithm. This supports the pathophysiological concept of inflammation as a typical, universal response of the body to exposure to a phlogogen of any origin, thereby substantiating the assertion that allergy is a particular manifestation of inflammation as a syndrome. A critical assessment is given to the current understanding of allergy pathogenesis, which distorts the cause-and-effect relationships in the sequence of processes that form the disease picture. A proposal has been put forward to consider biochemical reactions occurring on mucous membranes and skin within the microbiome's environment as neutralizing the antigenic properties of external protein structures through enzymatic breakdown into low-molecular-weight products. These products, upon penetrating the internal environment, lose their ability to trigger an inflammatory response involving the immune system. The duality of inflammation, in which localized and generalized forms are combined, is considered as a morphologically justified manifestation of opposing protective and destructive effects on the microorganism.},
 year = {2026}
}

Copy | Download

TY  - JOUR
T1  - A Shift in Classical Concepts Regarding Pathophysiology, Driven by a Realistic Perception of the Pathogenesis of Allergic Reactions
AU  - Alexey Gareev
Y1  - 2026/09/27
PY  - 2026
N1  - https://doi.org/10.11648/j.ajhr.20261405.13
DO  - 10.11648/j.ajhr.20261405.13
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 242
EP  - 254
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20261405.13
AB  - This review proposes assessing the animal organism, its state of life, health, and response to external factors from the perspective of ontological constructivism, attempting to analyze the best-known, and thus accessible, components of the biological life process. The evolution of responses is examined in a sequence of stages termed by the author "natural lavage with mucosal secretions," "pre-inflammation," and then aseptic inflammation and antigen-dependent inflammation. Emphasis is placed on the fact that the immune system is a unified structure that interacts with antigens of both infectious and non-infectious origins according to a single algorithm. This supports the pathophysiological concept of inflammation as a typical, universal response of the body to exposure to a phlogogen of any origin, thereby substantiating the assertion that allergy is a particular manifestation of inflammation as a syndrome. A critical assessment is given to the current understanding of allergy pathogenesis, which distorts the cause-and-effect relationships in the sequence of processes that form the disease picture. A proposal has been put forward to consider biochemical reactions occurring on mucous membranes and skin within the microbiome's environment as neutralizing the antigenic properties of external protein structures through enzymatic breakdown into low-molecular-weight products. These products, upon penetrating the internal environment, lose their ability to trigger an inflammatory response involving the immune system. The duality of inflammation, in which localized and generalized forms are combined, is considered as a morphologically justified manifestation of opposing protective and destructive effects on the microorganism.
VL  - 14
IS  - 5
ER  -

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