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Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism

Received: 24 November 2014     Accepted: 9 December 2014     Published: 14 January 2015
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Abstract

The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.

Published in American Journal of Life Sciences (Volume 3, Issue 1)
DOI 10.11648/j.ajls.20150301.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Resistance, Combination, Plant Products, Synergism, Antagonism

References
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[3] Gibbons, S. (2004). Anti-Staphylococcal plant natural products. Nat. Prod. Rep. 21: 263-277
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[5] Udobi, Chinweizu Ejikeme. (2008). Antibacterial activities and phytochemical analysis of the Leaf, Stem bark and root of the African Locust Bean (Parkia biglobosa) (Jacq) Benth (Mimosaceae). PhD. Dissertation. Ahmadu Bello University, Zaria.
[6] Lewis, K. Ausubel, F. M. (2006). Prospects for plant derived antibacterials. Nat. Biotechnol. 24(12): 1504-1507.
[7] Nwozo S. O, Iwuoha E. I., Waryo T and Kgarebe B (2014). Isolation, Partial purification and characterization of antifungal trypsin inhibitor protease from the seed of Blighia sapida K. D Koenig (Ackee). Afri. Journ. Biotech. 13 (29) 2996-3007.
[8] Esuoso KO, Odetoun SM. Proximate chemical composition and possibleindustrial utilization of B. sapida seed and oils. Journal of Phytotherapy Research 2005; 72(7):311–313.
[9] John-Dewole, O. O. and Popoola, O. O. (2013). Chemical, Phytochemical and Antimicrobial Screening of Extracts of B. sapida for Agricultural and Medicinal Relevance. Nature and science, vol. 11(I10) 12-17
[10] Veronica M. Dossou, Jacob K. Agbenorhevi, Sussana combey, Sarah Afi-Koryoe (2014). Ackee (Bilghia sapida) fruit arils: Nutritional, phytochemicals and antioxidant properties. Int. Journ. Nut. Food Sci. 3 (6) 534-537
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[14] Zhao,W.H., Hu, Z.O. Okubo, S, Hara, Y., shimanura, T. (2001). Mechanism of synergy between Epigallocatechin gallate and lactams against methicillin resistant staphylococcus aureus. Antimicrobial. Agents chemother. 45(6): 1737 – 1742
[15] Ubulom, P. M; Udobi, C. E; Akpabio, E. I; Eshiet, U. (2013). Antimicrobial activities of Leaf and Stem bark extracts of Blighia sapida Journal of Plant Studies; 2 ( 2) 47-52
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  • APA Style

    Udobi Chinweizu Ejikeme, Daniel Mbuotidem David. (2015). Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. American Journal of Life Sciences, 3(1), 1-5. https://doi.org/10.11648/j.ajls.20150301.11

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    ACS Style

    Udobi Chinweizu Ejikeme; Daniel Mbuotidem David. Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. Am. J. Life Sci. 2015, 3(1), 1-5. doi: 10.11648/j.ajls.20150301.11

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    AMA Style

    Udobi Chinweizu Ejikeme, Daniel Mbuotidem David. Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism. Am J Life Sci. 2015;3(1):1-5. doi: 10.11648/j.ajls.20150301.11

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  • @article{10.11648/j.ajls.20150301.11,
      author = {Udobi Chinweizu Ejikeme and Daniel Mbuotidem David},
      title = {Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.ajls.20150301.11},
      url = {https://doi.org/10.11648/j.ajls.20150301.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.11},
      abstract = {The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.},
     year = {2015}
    }
    

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    AU  - Udobi Chinweizu Ejikeme
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    DO  - 10.11648/j.ajls.20150301.11
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
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    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150301.11
    AB  - The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.
    VL  - 3
    IS  - 1
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Author Information
  • Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

  • Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

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