Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community

Ezra Agbo; Victor Ogugua; Innocent Okagu; Collins Amadi; Aloysius Aleke

doi:doi:10.11648/j.cajph.20220802.12

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Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community

Ezra Agbo, Victor Ogugua, Innocent Okagu, Collins Amadi, Aloysius Aleke

Published in Central African Journal of Public Health (Volume 8, Issue 2)

Received: 14 February 2022 Accepted: 4 March 2022 Published: 11 March 2022

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Abstract

Background: This study was conducted to determine the prevalence of metabolic syndrome and oxidative stress among type 2 diabetes mellitus (DM) patients in Enugu metropolis. Materials and Methods: Two hundred and forty participants aged 40-80 years attending Diabetic Clinic, University of Nigeria Teaching Hospital, Nigeria with their age and gender-marched healthy individuals were recruited as subjects and controls respectively, and evaluated for metabolic syndrome using the National Cholesterol Education Programme-Adult Treatment Panel III criteria. Oxidative stress markers were assayed spectrophotometrically. Results: Prevalence of metabolic syndrome was found to be 56% among type 2 DM patients (55% for males and 58% for females), and 15% among apparently healthy individuals. Besides raised fasting blood glucose in the subjects, the second abnormal parameter was raised blood pressure (86%), followed by low high-density lipoproteins (45%), central obesity (33%), and raised fasting triglycerides (17%) in that particular order. Furthermore, oxidative stress markers were found to have changed significantly in subjects when compared to controls: Malondialdehyde values and superoxide dismutase activities were significantly higher while ascorbic acid values were significantly lower. Conclusion: It can be concluded from this study that metabolic syndrome and disturbances of reduction-oxidation homeostasis are common among type 2 DM patients.

Published in	Central African Journal of Public Health (Volume 8, Issue 2)
DOI	10.11648/j.cajph.20220802.12
Page(s)	28-32
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Metabolic Syndrome, Oxidative Stress, Type 2 Diabetes

References

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APA Style

Ezra Agbo, Victor Ogugua, Innocent Okagu, Collins Amadi, Aloysius Aleke. (2022). Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Central African Journal of Public Health, 8(2), 28-32. https://doi.org/10.11648/j.cajph.20220802.12

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ACS Style

Ezra Agbo; Victor Ogugua; Innocent Okagu; Collins Amadi; Aloysius Aleke. Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Cent. Afr. J. Public Health 2022, 8(2), 28-32. doi: 10.11648/j.cajph.20220802.12

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AMA Style

Ezra Agbo, Victor Ogugua, Innocent Okagu, Collins Amadi, Aloysius Aleke. Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Cent Afr J Public Health. 2022;8(2):28-32. doi: 10.11648/j.cajph.20220802.12

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@article{10.11648/j.cajph.20220802.12,
  author = {Ezra Agbo and Victor Ogugua and Innocent Okagu and Collins Amadi and Aloysius Aleke},
  title = {Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community},
  journal = {Central African Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {28-32},
  doi = {10.11648/j.cajph.20220802.12},
  url = {https://doi.org/10.11648/j.cajph.20220802.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20220802.12},
  abstract = {Background: This study was conducted to determine the prevalence of metabolic syndrome and oxidative stress among type 2 diabetes mellitus (DM) patients in Enugu metropolis. Materials and Methods: Two hundred and forty participants aged 40-80 years attending Diabetic Clinic, University of Nigeria Teaching Hospital, Nigeria with their age and gender-marched healthy individuals were recruited as subjects and controls respectively, and evaluated for metabolic syndrome using the National Cholesterol Education Programme-Adult Treatment Panel III criteria. Oxidative stress markers were assayed spectrophotometrically. Results: Prevalence of metabolic syndrome was found to be 56% among type 2 DM patients (55% for males and 58% for females), and 15% among apparently healthy individuals. Besides raised fasting blood glucose in the subjects, the second abnormal parameter was raised blood pressure (86%), followed by low high-density lipoproteins (45%), central obesity (33%), and raised fasting triglycerides (17%) in that particular order. Furthermore, oxidative stress markers were found to have changed significantly in subjects when compared to controls: Malondialdehyde values and superoxide dismutase activities were significantly higher while ascorbic acid values were significantly lower. Conclusion: It can be concluded from this study that metabolic syndrome and disturbances of reduction-oxidation homeostasis are common among type 2 DM patients.},
 year = {2022}
}

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TY  - JOUR
T1  - Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community
AU  - Ezra Agbo
AU  - Victor Ogugua
AU  - Innocent Okagu
AU  - Collins Amadi
AU  - Aloysius Aleke
Y1  - 2022/03/11
PY  - 2022
N1  - https://doi.org/10.11648/j.cajph.20220802.12
DO  - 10.11648/j.cajph.20220802.12
T2  - Central African Journal of Public Health
JF  - Central African Journal of Public Health
JO  - Central African Journal of Public Health
SP  - 28
EP  - 32
PB  - Science Publishing Group
SN  - 2575-5781
UR  - https://doi.org/10.11648/j.cajph.20220802.12
AB  - Background: This study was conducted to determine the prevalence of metabolic syndrome and oxidative stress among type 2 diabetes mellitus (DM) patients in Enugu metropolis. Materials and Methods: Two hundred and forty participants aged 40-80 years attending Diabetic Clinic, University of Nigeria Teaching Hospital, Nigeria with their age and gender-marched healthy individuals were recruited as subjects and controls respectively, and evaluated for metabolic syndrome using the National Cholesterol Education Programme-Adult Treatment Panel III criteria. Oxidative stress markers were assayed spectrophotometrically. Results: Prevalence of metabolic syndrome was found to be 56% among type 2 DM patients (55% for males and 58% for females), and 15% among apparently healthy individuals. Besides raised fasting blood glucose in the subjects, the second abnormal parameter was raised blood pressure (86%), followed by low high-density lipoproteins (45%), central obesity (33%), and raised fasting triglycerides (17%) in that particular order. Furthermore, oxidative stress markers were found to have changed significantly in subjects when compared to controls: Malondialdehyde values and superoxide dismutase activities were significantly higher while ascorbic acid values were significantly lower. Conclusion: It can be concluded from this study that metabolic syndrome and disturbances of reduction-oxidation homeostasis are common among type 2 DM patients.
VL  - 8
IS  - 2
ER  -

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Author Information

Ezra Agbo

Department of Chemical Pathology, Federal Medical Centre, Owerri, Nigeria
Victor Ogugua

Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
Innocent Okagu

Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
Collins Amadi

Department of Chemical Pathology, Rivers State University/Rivers State University Teaching Hospital, Port Harcourt, Nigeria
Aloysius Aleke

Everight Diagnostics and Laboratory Services Limited, Abuja, Nigeria

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APA Style

Ezra Agbo, Victor Ogugua, Innocent Okagu, Collins Amadi, Aloysius Aleke. (2022). Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Central African Journal of Public Health, 8(2), 28-32. https://doi.org/10.11648/j.cajph.20220802.12

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ACS Style

Ezra Agbo; Victor Ogugua; Innocent Okagu; Collins Amadi; Aloysius Aleke. Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Cent. Afr. J. Public Health 2022, 8(2), 28-32. doi: 10.11648/j.cajph.20220802.12

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AMA Style

Ezra Agbo, Victor Ogugua, Innocent Okagu, Collins Amadi, Aloysius Aleke. Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community. Cent Afr J Public Health. 2022;8(2):28-32. doi: 10.11648/j.cajph.20220802.12

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@article{10.11648/j.cajph.20220802.12,
  author = {Ezra Agbo and Victor Ogugua and Innocent Okagu and Collins Amadi and Aloysius Aleke},
  title = {Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community},
  journal = {Central African Journal of Public Health},
  volume = {8},
  number = {2},
  pages = {28-32},
  doi = {10.11648/j.cajph.20220802.12},
  url = {https://doi.org/10.11648/j.cajph.20220802.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20220802.12},
  abstract = {Background: This study was conducted to determine the prevalence of metabolic syndrome and oxidative stress among type 2 diabetes mellitus (DM) patients in Enugu metropolis. Materials and Methods: Two hundred and forty participants aged 40-80 years attending Diabetic Clinic, University of Nigeria Teaching Hospital, Nigeria with their age and gender-marched healthy individuals were recruited as subjects and controls respectively, and evaluated for metabolic syndrome using the National Cholesterol Education Programme-Adult Treatment Panel III criteria. Oxidative stress markers were assayed spectrophotometrically. Results: Prevalence of metabolic syndrome was found to be 56% among type 2 DM patients (55% for males and 58% for females), and 15% among apparently healthy individuals. Besides raised fasting blood glucose in the subjects, the second abnormal parameter was raised blood pressure (86%), followed by low high-density lipoproteins (45%), central obesity (33%), and raised fasting triglycerides (17%) in that particular order. Furthermore, oxidative stress markers were found to have changed significantly in subjects when compared to controls: Malondialdehyde values and superoxide dismutase activities were significantly higher while ascorbic acid values were significantly lower. Conclusion: It can be concluded from this study that metabolic syndrome and disturbances of reduction-oxidation homeostasis are common among type 2 DM patients.},
 year = {2022}
}

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TY  - JOUR
T1  - Metabolic Syndrome and Oxidative Stress Among Patients of Type 2 Diabetes in an African Community
AU  - Ezra Agbo
AU  - Victor Ogugua
AU  - Innocent Okagu
AU  - Collins Amadi
AU  - Aloysius Aleke
Y1  - 2022/03/11
PY  - 2022
N1  - https://doi.org/10.11648/j.cajph.20220802.12
DO  - 10.11648/j.cajph.20220802.12
T2  - Central African Journal of Public Health
JF  - Central African Journal of Public Health
JO  - Central African Journal of Public Health
SP  - 28
EP  - 32
PB  - Science Publishing Group
SN  - 2575-5781
UR  - https://doi.org/10.11648/j.cajph.20220802.12
AB  - Background: This study was conducted to determine the prevalence of metabolic syndrome and oxidative stress among type 2 diabetes mellitus (DM) patients in Enugu metropolis. Materials and Methods: Two hundred and forty participants aged 40-80 years attending Diabetic Clinic, University of Nigeria Teaching Hospital, Nigeria with their age and gender-marched healthy individuals were recruited as subjects and controls respectively, and evaluated for metabolic syndrome using the National Cholesterol Education Programme-Adult Treatment Panel III criteria. Oxidative stress markers were assayed spectrophotometrically. Results: Prevalence of metabolic syndrome was found to be 56% among type 2 DM patients (55% for males and 58% for females), and 15% among apparently healthy individuals. Besides raised fasting blood glucose in the subjects, the second abnormal parameter was raised blood pressure (86%), followed by low high-density lipoproteins (45%), central obesity (33%), and raised fasting triglycerides (17%) in that particular order. Furthermore, oxidative stress markers were found to have changed significantly in subjects when compared to controls: Malondialdehyde values and superoxide dismutase activities were significantly higher while ascorbic acid values were significantly lower. Conclusion: It can be concluded from this study that metabolic syndrome and disturbances of reduction-oxidation homeostasis are common among type 2 DM patients.
VL  - 8
IS  - 2
ER  -

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