Cancer is the leading cause of death and a major obstacle to increasing life expectancy worldwide in the 21st century. Oral cavity cancers are the most common type of head and neck cancers. This study aimed to determine the polymorphism and genetic diversity of the tumor protein P53 (TP53) in oral cavity cancers in Senegal. From a total of 40 patients with oral cavity cancer, we collected 40 cancerous tissue samples, 20 adjacent healthy tissue samples, and 15 blood samples. Blood samples were collected from participants in the control group. Tissue samples were obtained from each patient during a biopsy after obtaining informed consent. DNA extraction, polymerase chain reaction (PCR), and sequencing were performed. MEGA, BioEdit, and DnaSP software were used to analyze polymorphisms and genetic diversity. A total of 36.80%, 22.27%, and 7.74% polymorphic sites were found in cancerous tissues, healthy tissues, and blood samples, respectively. Nine amino acids showed significant differences in distribution between participants in the control group and patients. Significant differences were also observed within and between populations. This study revealed an increasing number of oral cancer cases in Senegal. Moreover, healthy tissues exhibited the same genetic alterations as cancerous tissues.
| Published in | Cancer Research Journal (Volume 13, Issue 2) |
| DOI | 10.11648/j.crj.20251302.13 |
| Page(s) | 46-55 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Cancer, Oral, Cavity, TP53, Polymorphism, Diversity, Senegal
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APA Style
Samb, M. D., Mbaye, F., Toure, S., Sembene, M. (2025). Polymorphism and Genetic Diversity in Senegalese Patients with Oral Cancers. Cancer Research Journal, 13(2), 46-55. https://doi.org/10.11648/j.crj.20251302.13
ACS Style
Samb, M. D.; Mbaye, F.; Toure, S.; Sembene, M. Polymorphism and Genetic Diversity in Senegalese Patients with Oral Cancers. Cancer Res. J. 2025, 13(2), 46-55. doi: 10.11648/j.crj.20251302.13
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Download@article{10.11648/j.crj.20251302.13,
author = {Mame Diarra Samb and Fatimata Mbaye and Silly Toure and Mbacke Sembene},
title = {Polymorphism and Genetic Diversity in Senegalese Patients with Oral Cancers
},
journal = {Cancer Research Journal},
volume = {13},
number = {2},
pages = {46-55},
doi = {10.11648/j.crj.20251302.13},
url = {https://doi.org/10.11648/j.crj.20251302.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20251302.13},
abstract = {Cancer is the leading cause of death and a major obstacle to increasing life expectancy worldwide in the 21st century. Oral cavity cancers are the most common type of head and neck cancers. This study aimed to determine the polymorphism and genetic diversity of the tumor protein P53 (TP53) in oral cavity cancers in Senegal. From a total of 40 patients with oral cavity cancer, we collected 40 cancerous tissue samples, 20 adjacent healthy tissue samples, and 15 blood samples. Blood samples were collected from participants in the control group. Tissue samples were obtained from each patient during a biopsy after obtaining informed consent. DNA extraction, polymerase chain reaction (PCR), and sequencing were performed. MEGA, BioEdit, and DnaSP software were used to analyze polymorphisms and genetic diversity. A total of 36.80%, 22.27%, and 7.74% polymorphic sites were found in cancerous tissues, healthy tissues, and blood samples, respectively. Nine amino acids showed significant differences in distribution between participants in the control group and patients. Significant differences were also observed within and between populations. This study revealed an increasing number of oral cancer cases in Senegal. Moreover, healthy tissues exhibited the same genetic alterations as cancerous tissues.
},
year = {2025}
}
TY - JOUR T1 - Polymorphism and Genetic Diversity in Senegalese Patients with Oral Cancers AU - Mame Diarra Samb AU - Fatimata Mbaye AU - Silly Toure AU - Mbacke Sembene Y1 - 2025/06/12 PY - 2025 N1 - https://doi.org/10.11648/j.crj.20251302.13 DO - 10.11648/j.crj.20251302.13 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 46 EP - 55 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20251302.13 AB - Cancer is the leading cause of death and a major obstacle to increasing life expectancy worldwide in the 21st century. Oral cavity cancers are the most common type of head and neck cancers. This study aimed to determine the polymorphism and genetic diversity of the tumor protein P53 (TP53) in oral cavity cancers in Senegal. From a total of 40 patients with oral cavity cancer, we collected 40 cancerous tissue samples, 20 adjacent healthy tissue samples, and 15 blood samples. Blood samples were collected from participants in the control group. Tissue samples were obtained from each patient during a biopsy after obtaining informed consent. DNA extraction, polymerase chain reaction (PCR), and sequencing were performed. MEGA, BioEdit, and DnaSP software were used to analyze polymorphisms and genetic diversity. A total of 36.80%, 22.27%, and 7.74% polymorphic sites were found in cancerous tissues, healthy tissues, and blood samples, respectively. Nine amino acids showed significant differences in distribution between participants in the control group and patients. Significant differences were also observed within and between populations. This study revealed an increasing number of oral cancer cases in Senegal. Moreover, healthy tissues exhibited the same genetic alterations as cancerous tissues. VL - 13 IS - 2 ER -
Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Department of Maxillofacial Surgery and Stomatology, Faculty of Medicine, Pharmacy and Stomatology, Cheikh Anta Diop University, Dakar, Senegal
Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
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