Research Article
Postmastectomy Experiences of Reproductive-Age Women (15-49), Harar, Ethiopia: A Qualitative Study
Aminu Mohammed Yasin*,
Ahmedin Aliyi Usso,
Leyla Abrar Bedru,
Hassen Mosa Halil,
Neima Redwan Abdu
Issue:
Volume 13, Issue 1, March 2025
Pages:
1-8
Received:
18 September 2024
Accepted:
31 December 2024
Published:
16 January 2025
DOI:
10.11648/j.crj.20251301.11
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Views:
Abstract: Background: Despite contemporary initiatives to raise breast cancer awareness, mastectomy as a surgical therapy for breast cancer may have a detrimental impact on a woman's life. Intervention to address the variety of challenges encountered in their personal and family lives postmastectomy is the other side of therapy. Purpose: The aim of this study was to examine the experiences of reproductive age (15-49 years old) women’s lives after breast surgery for breast cancer. Methods: This qualitative study was conducted at a tertiary cancer center in Harar, Ethiopia, between February and March 2023. Study setting, and participants selected using the purposive sampling technique and interviewed individually using a semi-structured interview guide with the assistance of a voice recorder. The data were transcribed verbatim and analyzed using a thematic approach. Results: Five main themes emerged from the data: body image changes, relationships with husbands and sexual life, health risks, silent stigma and perception of sinfulness by society, and coping with life postmastectomy. Conclusions: Following a mastectomy, women face various challenges emanating from their own perceptions, their husbands, and society. The study's findings are helpful in advancing knowledge of a variety of challenges encountered postmastectomy and coping strategies. It is essential to actively incorporate psycho-emotional and husband-supportive rehabilitation into their care, creating community awareness to solve misconceptions, and additional multi-perspective research.
Abstract: Background: Despite contemporary initiatives to raise breast cancer awareness, mastectomy as a surgical therapy for breast cancer may have a detrimental impact on a woman's life. Intervention to address the variety of challenges encountered in their personal and family lives postmastectomy is the other side of therapy. Purpose: The aim of this stud...
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Research Article
A Novel Ferroptosis-Related lncRNA Prognostic Signature for Colorectal Cancer by Bioinformatics Analysis
Issue:
Volume 13, Issue 1, March 2025
Pages:
9-22
Received:
3 April 2025
Accepted:
21 April 2025
Published:
19 May 2025
DOI:
10.11648/j.crj.20251301.12
Downloads:
Views:
Abstract: Recently, extensive studies have shown that ferroptosis boosted a perspective for its usage in cancer therapeutics. The current study aims to construct a robust ferroptosis-related lncRNAs signature prediction model to increase the predicted value of colorectal cancer (CRC) by bioinformatics analysis. By comparing CRC tissue with adjacent normal tissues, we screened 2541 differentially expressed lncRNAs from The Cancer Genome Atlas (TCGA) CRC using the R language and "limma" package, of which 439 are ferroptosis-related lncRNAs. Univariate Cox regression, lasso regression, multivariate Cox regression are used to construct a seven ferroptosis-related lncRNAs (AC005550.2, LINC02381, AL137782.1, C2orf27A, AC156455.1, AL354993.2, AC008760.1) prognostic signature in train set. This model's prognosis in the high-risk group is worse than that of the low-risk group in the train set, test set, and entire set. Based on the stratification of clinical variables (gender, age, clinical stage, postoperative tumor status, CEA levels, perineural invasion, vascular invasion, mismatch repair (MMR) and gene mutation status (KRAS, BRAF)), the high-risk group's prognosis is also worse than that of the low-risk group. The area under curve (AUC) of receiver operating characteristic (ROC) curve for predicting three years survival in the train set, test set, and entire set were 0.796, 0.715, and 0.758, respectively. Furthermore, Univariate Cox regression and multivariate Cox regression displayed that the signature could serve as an independent prognostic factor; meanwhile, we draw the nomogram based on multivariate Cox regression (P<0.05). Compared to clinical variables, this signature's ROC curves demonstrated the second largest AUC value (0.737). The expression of these lncRNAs and the lncRNA signature are related to clinical stage, T stage, Lymph-node status, distant metastasis, KRAS mutation, BRAF mutation, MMR status, and perineural invasion. Finally, GSEA analysis results show that the signature is involved in six KEGG signal pathways, such as KEGG_HEDGEHOG_SIGNALING_PATHWAY, KEGG_ALPHA_LINOLENIC_ACID_METABOLISM, KEGG_ARACHIDONIC_ACID_METABOLISM, KEGG_CITRATE_CYCLE_TCA_CYCLE, KEGG_PENTOSE_PHOSPHATE_PATHWAY, KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM. In conclusion, the current study shows a seven ferroptosis-related lncRNA signature could efficiently function as a novel and independent prognosis biomarker and therapeutic target for CRC patients.
Abstract: Recently, extensive studies have shown that ferroptosis boosted a perspective for its usage in cancer therapeutics. The current study aims to construct a robust ferroptosis-related lncRNAs signature prediction model to increase the predicted value of colorectal cancer (CRC) by bioinformatics analysis. By comparing CRC tissue with adjacent normal ti...
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,
Guodong Yang
