Biomaterials in Medicine: Current Trends and Future Directions

Fahad Alshabona; Ahmad Fallatah; Ibraheem Redhwi

doi:doi:10.11648/j.ijbmr.20251301.13

Review Article |

| Peer-Reviewed

Biomaterials in Medicine: Current Trends and Future Directions

Fahad Alshabona

, Ahmad Fallatah^*

, Ibraheem Redhwi

Published in International Journal of Biomedical Materials Research (Volume 13, Issue 1)

Received: 3 March 2025 Accepted: 21 April 2025 Published: 22 May 2025

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Contemporary medicine relies significantly on biomaterials as essential elements across various applications. From polymers and ceramics to metals and hydrogels, these materials enable innovations in implants, drug delivery systems, and tissue engineering, ultimately enhancing patient care and treatment outcomes. In this review, we explore current trends in biomaterials and their applications, emphasizing recent innovations, particularly in biocompatibility, biodegradability, and functionality. We also discuss emerging technologies such as 3D printing, smart biomaterials and nanotechnology, which are transforming the field of biomaterials. Furthermore, we identify challenges and opportunities in biomaterials research, highlighting potential future directions. The integration of biomaterials with cutting-edge technologies has opened new avenues for personalized medicine, regenerative medicine, and targeted therapies. This review seeks to bridge the gap between biomaterials research and clinical applications, providing insights into the latest developments and future prospects. By exploring the current landscape of biomaterials, we aim to inspire further research and innovation in this rapidly evolving field. Ultimately, this review will contribute to the advancement of biomaterials and their applications, improving patient outcomes and shaping the future of medicine.

Published in	International Journal of Biomedical Materials Research (Volume 13, Issue 1)
DOI	10.11648/j.ijbmr.20251301.13
Page(s)	24-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Biomaterial, Drug, Tissue, Biocompatibility, Biodegradable, Nanotechnology, Medicine, Patient

References

[1]	Tappa, K., & Jammalamadaka, U. 2018. Novel Biomaterials Used in Medical 3D Printing Techniques. Journal of Functional Biomaterials, 2018, 9(1): p. 17. https://doi.org/10.3390/jfb9010017
[2]	Riha, S. M., Maarof, M., & Fauzi, M. B. Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review. Polymers, 2020, 13(10): p. 1546. https://doi.org/10.3390/polym13101546
[3]	Gerold, E., Antrekowitsch, H. A Sustainable Approach for the Recovery of Manganese from Spent Lithium-Ion Batteries via Photocatalytic Oxidation. International Journal of Materials Science and Applications. 2022, 11(3), 66-75. https://doi.org/10.11648/j.ijmsa.20221103.12
[4]	Hashmi, M. P., Koester, T. M. Applications of synthetically produced materials in clinical medicine. 2018.
[5]	Othman, Z., et al. Understanding interactions between biomaterials and biological systems using proteomics. Biomaterials, 2018. 167: p. 191-204. https://doi.org/10.1016/j.biomaterials.2018.03.023
[6]	Farag, M. M. Recent trends on biomaterials for tissue regeneration applications. Journal of Materials Science, 2023. 58(2): p. 527-558. https://doi.org/10.1007/s10853-022-07963-4
[7]	Wyss, U. P. Improving the Quality of Life of Patients With Medical Devices by a Timely Analysis of Adverse Events. Frontiers in Medicine, 2019. 6: p. 56. https://doi.org/10.3389/fmed.2019.00056
[8]	Huzum, B., et al. Biocompatibility assessment of biomaterials used in orthopaedic devices: An overview. Experimental and Therapeutic Medicine, 2021. 22(5): p. 1-9. https://doi.org/10.3892/etm.2021.10464
[9]	Kurowiak, J., Klekiel, T., Będziński, R. Biodegradable Polymers in Biomedical Applications: A Review—Developments, Perspectives and Future Challenges. International Journal of Molecular Sciences, 2023. 24(23): p. 16952. https://doi.org/10.3390/ijms242316952
[10]	Oleksy, M., Dynarowicz, K., Aebisher, D. Advances in biodegradable polymers and biomaterials for medical applications—a review. Molecules, 2023. 28(17): p. 6213. https://doi.org/10.3390/molecules28176213
[11]	Oliver‐Cervelló, L., Martin‐Gómez, H., Mas‐Moruno, C. New trends in the development of multifunctional peptides to functionalize biomaterials. Journal of Peptide Science, 2022. 28(1): p. e3335. https://doi.org/10.1002/psc.3335
[12]	Narkar, A. R., et al. Smart biomaterial platforms: Controlling and being controlled by cells. Biomaterials, 2022. 283: p. 121450. https://doi.org/10.1016/j.biomaterials.2022.121450
[13]	Oliveira, J. M., Reis, R. L. Biomaterials and emerging technologies for tissue engineering and in vitro models. Bio-Design and Manufacturing, 2024: p. 1-3. https://doi.org/10.1007/s42242-023-00257-4
[14]	Montoya, C., et al. On the road to smart biomaterials for bone research: Definitions, concepts, advances, and outlook. Bone research, 2021. 9(1): p. 12. https://doi.org/10.1038/s41413-021-00141-8
[15]	Bhatti, S., Singh, J. 3D printing of biomaterials for biomedical applications: A review. International Journal on Interactive Design and Manufacturing (IJIDeM), 2023: p. 1-22.
[16]	Shopova, D., et al. (Bio) printing in personalized medicine—opportunities and potential benefits. Bioengineering, 2023. 10(3): p. 287. https://doi.org/10.3390/bioengineering10030287
[17]	Martín-Noguerol, T., et al. Hybrid computed tomography and magnetic resonance imaging 3D printed models for neurosurgery planning. Annals of translational medicine, 2019. 7(22). https://doi.org/10.21037/atm.2019.10.61
[18]	Kumarage, V., et al. Nanotechnology Applications in Biomaterials; A review. J. Res. Technol. Eng, 2022. 3: p. 32-54.
[19]	Aththanayaka, S., Thiripuranathar, G., Ekanayake, S. Emerging advances in biomimetic synthesis of nanocomposites and potential applications. Materials Today Sustainability, 2022. 20: p. 100206. https://doi.org/10.1016/j.mtsust.2022.100206
[20]	Elumalai, K., Srinivasan, S., Shanmugam, A. Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment. Biomedical Technology, 2024. 5: p. 109-122.
[21]	Khan, H. M., et al. Smart biomaterials and their potential applications in tissue engineering. Journal of Materials Chemistry B, 2022. 10(36): p. 6859-6895. https://doi.org/10.1039/D2TB01055A
[22]	Wei, H., et al. Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration. Bone research, 2022. 10(1): p. 17. https://doi.org/10.1038/s41413-022-00183-4
[23]	Salim, S. A., et al. Smart biomaterials for enhancing cancer therapy by overcoming tumor hypoxia: a review. RSC advances, 2022. 12(52): p. 33835-33851. https://doi.org/10.1039/D2RA05744B
[24]	Ezike, T. C., et al. Advances in drug delivery systems, challenges and future directions. Heliyon, 2023. 9(6). https://doi.org/10.1016/j.heliyon.2023.e16855
[25]	Gokcekuyu, Y., et al. Artificial Intelligence in Biomaterials: A Comprehensive Review. Applied Sciences, 2024. 14(15): p. 6590. https://doi.org/10.3390/app14156590
[26]	Nosrati, H., Nosrati, M. Artificial intelligence in regenerative medicine: applications and implications. Biomimetics, 2023. 8(5): p. 442. https://doi.org/10.3390/biomimetics8050442
[27]	Jarrige, M., et al. The future of regenerative medicine: cell therapy using pluripotent stem cells and acellular therapies based on extracellular vesicles. Cells, 2021. 10(2): p. 240. https://doi.org/10.3390/cells10020240
[28]	Association, A. N. Ethics and Human Rights. 2020.
[29]	Xu, J., et al. The personalized application of biomaterials based on age and sexuality specific immune responses. Biomaterials, 2021. 278: p. 121177. https://doi.org/10.1016/j.biomaterials.2021.121177
[30]	Wu, C., et al. Machine Learning in Biomaterials, Biomechanics/Mechanobiology, and Biofabrication: State of the Art and Perspective. Archives of Computational Methods in Engineering, 2024: p. 1-67. https://doi.org/10.1007/s11831-023-10024-1
[31]	Wang, H. Biomaterials in Medical Applications. Polymers, 2022, 15(4): p. 847. https://doi.org/10.3390/polym15040847
[32]	Silva, D. F., Melo, A. L., Uchôa, A. F., Pereira, G. M., Alves, A. E., Vasconcellos, M. C., H., F., & Passos, M. F. Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review. International Journal of Molecular Sciences, 2022, 24(23): p. 16719. https://doi.org/10.3390/ijms242316719
[33]	Uludağ, H., Wang, Y., Vrana, N. E., Tamerler, C., Kothapalli, C., & Vasudev, M. C. Editorial: Insights in biomaterials 2022 / 2023—Novel developments, current challenges and future perspectives. Frontiers in Bioengineering and Biotechnology, 2024, 12, p. 1364724. https://doi.org/10.3389/fbioe.2024.1364724
[34]	Garmany, A., & Terzic, A. Artificial intelligence powers regenerative medicine into predictive realm. Regenerative Medicine, 2024, 19(12), p. 611. https://doi.org/10.1080/17460751.2024.2437281
[35]	Han, S., & Wu, J. Artificial intelligence (AI) meets biomaterials and biomedicine. Smart Materials in Medicine, 2024, 5(2), p. 251-255. https://doi.org/10.1016/j.smaim.2024.03.001
[36]	Gokcekuyu, Y., Ekinci, F., Guzel, M. S., Acici, K., Aydin, S., & Asuroglu, T. Artificial Intelligence in Biomaterials: A Comprehensive Review. Applied Sciences, 2023, 14(15), p. 6590. https://doi.org/10.3390/app14156590
[37]	Asadi Sarabi, P., Shabanpouremam, M., Eghtedari, A. R., Barat, M., Moshiri, B., Zarrabi, A., & Vosough, M. AI-Based solutions for current challenges in regenerative medicine. European Journal of Pharmacology, 2024, 984, p. 177067. https://doi.org/10.1016/j.ejphar.2024.177067
[38]	Gharibshahian, M., Torkashvand, M., Bavisi, M., Aldaghi, N., & Alizadeh, A. Recent advances in artificial intelligent strategies for tissue engineering and regenerative medicine. Skin Research and Technology, 2024, 30(9), e70016. https://doi.org/10.1111/srt.70016

Cite This Article

Plain Text BibTeX RIS

APA Style

Alshabona, F., Fallatah, A., Redhwi, I. (2025). Biomaterials in Medicine: Current Trends and Future Directions. International Journal of Biomedical Materials Research, 13(1), 24-31. https://doi.org/10.11648/j.ijbmr.20251301.13

Copy | Download

ACS Style

Alshabona, F.; Fallatah, A.; Redhwi, I. Biomaterials in Medicine: Current Trends and Future Directions. Int. J. Biomed. Mater. Res. 2025, 13(1), 24-31. doi: 10.11648/j.ijbmr.20251301.13

Copy | Download

AMA Style

Alshabona F, Fallatah A, Redhwi I. Biomaterials in Medicine: Current Trends and Future Directions. Int J Biomed Mater Res. 2025;13(1):24-31. doi: 10.11648/j.ijbmr.20251301.13

Copy | Download

@article{10.11648/j.ijbmr.20251301.13,
  author = {Fahad Alshabona and Ahmad Fallatah and Ibraheem Redhwi},
  title = {Biomaterials in Medicine: Current Trends and Future Directions
},
  journal = {International Journal of Biomedical Materials Research},
  volume = {13},
  number = {1},
  pages = {24-31},
  doi = {10.11648/j.ijbmr.20251301.13},
  url = {https://doi.org/10.11648/j.ijbmr.20251301.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20251301.13},
  abstract = {Contemporary medicine relies significantly on biomaterials as essential elements across various applications. From polymers and ceramics to metals and hydrogels, these materials enable innovations in implants, drug delivery systems, and tissue engineering, ultimately enhancing patient care and treatment outcomes. In this review, we explore current trends in biomaterials and their applications, emphasizing recent innovations, particularly in biocompatibility, biodegradability, and functionality. We also discuss emerging technologies such as 3D printing, smart biomaterials and nanotechnology, which are transforming the field of biomaterials. Furthermore, we identify challenges and opportunities in biomaterials research, highlighting potential future directions. The integration of biomaterials with cutting-edge technologies has opened new avenues for personalized medicine, regenerative medicine, and targeted therapies. This review seeks to bridge the gap between biomaterials research and clinical applications, providing insights into the latest developments and future prospects. By exploring the current landscape of biomaterials, we aim to inspire further research and innovation in this rapidly evolving field. Ultimately, this review will contribute to the advancement of biomaterials and their applications, improving patient outcomes and shaping the future of medicine.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Biomaterials in Medicine: Current Trends and Future Directions

AU  - Fahad Alshabona
AU  - Ahmad Fallatah
AU  - Ibraheem Redhwi
Y1  - 2025/05/22
PY  - 2025
N1  - https://doi.org/10.11648/j.ijbmr.20251301.13
DO  - 10.11648/j.ijbmr.20251301.13
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 24
EP  - 31
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20251301.13
AB  - Contemporary medicine relies significantly on biomaterials as essential elements across various applications. From polymers and ceramics to metals and hydrogels, these materials enable innovations in implants, drug delivery systems, and tissue engineering, ultimately enhancing patient care and treatment outcomes. In this review, we explore current trends in biomaterials and their applications, emphasizing recent innovations, particularly in biocompatibility, biodegradability, and functionality. We also discuss emerging technologies such as 3D printing, smart biomaterials and nanotechnology, which are transforming the field of biomaterials. Furthermore, we identify challenges and opportunities in biomaterials research, highlighting potential future directions. The integration of biomaterials with cutting-edge technologies has opened new avenues for personalized medicine, regenerative medicine, and targeted therapies. This review seeks to bridge the gap between biomaterials research and clinical applications, providing insights into the latest developments and future prospects. By exploring the current landscape of biomaterials, we aim to inspire further research and innovation in this rapidly evolving field. Ultimately, this review will contribute to the advancement of biomaterials and their applications, improving patient outcomes and shaping the future of medicine.

VL  - 13
IS  - 1
ER  -

Copy | Download

Author Information

Fahad Alshabona

Advance Materials Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia

Contact Email

http://orcid.org/0000-0001-6966-8701
Ahmad Fallatah

Future Mobility Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia

Contact Email

http://orcid.org/0000-0001-6483-6454
Ibraheem Redhwi

Advance Materials Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia

Contact Email

http://orcid.org/0000-0001-9409-6346

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Alshabona, F., Fallatah, A., Redhwi, I. (2025). Biomaterials in Medicine: Current Trends and Future Directions. International Journal of Biomedical Materials Research, 13(1), 24-31. https://doi.org/10.11648/j.ijbmr.20251301.13

Copy | Download

ACS Style

Alshabona, F.; Fallatah, A.; Redhwi, I. Biomaterials in Medicine: Current Trends and Future Directions. Int. J. Biomed. Mater. Res. 2025, 13(1), 24-31. doi: 10.11648/j.ijbmr.20251301.13

Copy | Download

AMA Style

Alshabona F, Fallatah A, Redhwi I. Biomaterials in Medicine: Current Trends and Future Directions. Int J Biomed Mater Res. 2025;13(1):24-31. doi: 10.11648/j.ijbmr.20251301.13

Copy | Download

@article{10.11648/j.ijbmr.20251301.13,
  author = {Fahad Alshabona and Ahmad Fallatah and Ibraheem Redhwi},
  title = {Biomaterials in Medicine: Current Trends and Future Directions
},
  journal = {International Journal of Biomedical Materials Research},
  volume = {13},
  number = {1},
  pages = {24-31},
  doi = {10.11648/j.ijbmr.20251301.13},
  url = {https://doi.org/10.11648/j.ijbmr.20251301.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20251301.13},
  abstract = {Contemporary medicine relies significantly on biomaterials as essential elements across various applications. From polymers and ceramics to metals and hydrogels, these materials enable innovations in implants, drug delivery systems, and tissue engineering, ultimately enhancing patient care and treatment outcomes. In this review, we explore current trends in biomaterials and their applications, emphasizing recent innovations, particularly in biocompatibility, biodegradability, and functionality. We also discuss emerging technologies such as 3D printing, smart biomaterials and nanotechnology, which are transforming the field of biomaterials. Furthermore, we identify challenges and opportunities in biomaterials research, highlighting potential future directions. The integration of biomaterials with cutting-edge technologies has opened new avenues for personalized medicine, regenerative medicine, and targeted therapies. This review seeks to bridge the gap between biomaterials research and clinical applications, providing insights into the latest developments and future prospects. By exploring the current landscape of biomaterials, we aim to inspire further research and innovation in this rapidly evolving field. Ultimately, this review will contribute to the advancement of biomaterials and their applications, improving patient outcomes and shaping the future of medicine.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Biomaterials in Medicine: Current Trends and Future Directions

AU  - Fahad Alshabona
AU  - Ahmad Fallatah
AU  - Ibraheem Redhwi
Y1  - 2025/05/22
PY  - 2025
N1  - https://doi.org/10.11648/j.ijbmr.20251301.13
DO  - 10.11648/j.ijbmr.20251301.13
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 24
EP  - 31
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20251301.13
AB  - Contemporary medicine relies significantly on biomaterials as essential elements across various applications. From polymers and ceramics to metals and hydrogels, these materials enable innovations in implants, drug delivery systems, and tissue engineering, ultimately enhancing patient care and treatment outcomes. In this review, we explore current trends in biomaterials and their applications, emphasizing recent innovations, particularly in biocompatibility, biodegradability, and functionality. We also discuss emerging technologies such as 3D printing, smart biomaterials and nanotechnology, which are transforming the field of biomaterials. Furthermore, we identify challenges and opportunities in biomaterials research, highlighting potential future directions. The integration of biomaterials with cutting-edge technologies has opened new avenues for personalized medicine, regenerative medicine, and targeted therapies. This review seeks to bridge the gap between biomaterials research and clinical applications, providing insights into the latest developments and future prospects. By exploring the current landscape of biomaterials, we aim to inspire further research and innovation in this rapidly evolving field. Ultimately, this review will contribute to the advancement of biomaterials and their applications, improving patient outcomes and shaping the future of medicine.

VL  - 13
IS  - 1
ER  -

Copy | Download