Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria

Kingsley Chukwuka Amaihunwa; Emmanuel Asuquo Etim; Everista Odaburhine Osime; Zacchaeus Awortu Jeremiah

doi:doi:10.11648/j.bs.20210703.14

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Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria

Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime, Zacchaeus Awortu Jeremiah

Published in Biomedical Sciences (Volume 7, Issue 3)

Received: 2 August 2021 Accepted: 11 August 2021 Published: 23 August 2021

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Abstract

Background/Objective: Obesity is a medical condition in which adipose tissue accumulates to the extent of having adverse effect on certain procaogulant factors such as: Human Plasminogen Activator Inhibitor (PAI), tissue Plasminogen Activator (t-PA) and Tissue Factor (TF) of adults in Nigeria. This study therefore aims to evaluate the impacts of obesity on PAI, t-PA, and TF in obese adult in Sapele, South-South Nigeria. Materials and Methods: 312 adults with obesity and 103 normal adults (used as controls) with age between 18 and 65 years were enrolled for this study. 4.5mls of venous blood was collected into EDTA containers for procoagulant activity measurement. Human Plasminogen Activator Inhibitor (PAI-1), Human tissue Plasminogen Activator (t-PA), and Human Tissue Factor (TF) values were determined using Enzyme Linked Immunosorbent Assay (ELISA) methods. Collated data was analyzed using Student’s t-test, correlation and one-way ANOVA followed by LSD post-hoc test and results were expressed as mean±standard deviation. Results: The BMI (Body Mass Index) of obese subjects and control subjects were 36.82±0.55kg/m² and 20.43±0.29 kg/m² respectively at p<0.001. t-PA level of obese subject was 344.34±43.58pg/ml while control group had t-PA value of 192.46±10.65pg/ml. In addition, PAI of obese people was 367.24±27.49pg/ml and control subject had PAI value of 253.37±11.11pg/ml. Human Tissue Factor (TF) of obese subject and control subjects were 93.31±7.25pg/ml and 66.59±2.76pg/ml respectively at p<0.01. Conclusion: The values of Plasminogen Activator Inhibitor, tissue Plasminogen Activator, and Human Tissue Factor were higher in people with obesity when compare with non-obese control group in Sapele Southern Nigeria.

Published in	Biomedical Sciences (Volume 7, Issue 3)
DOI	10.11648/j.bs.20210703.14
Page(s)	81-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Obesity, PAI-1, t-PA, Tissue-Factor, Sapele

References

[1]	World Health Organization. (2015). Health effects of overweight and obesity in 195 countries over 25 years - obesity calibrator. England Journal of medicine 377 (1): 13-27.
[2]	Barness, L. A., Opitz, J. M and Gilbert, E. (2007). Obesity: genetic, molecular and environmental aspects. American Journal of Medical Genetics. 143 (24): 3016–3034.
[3]	Haslam, D. W and James, W. P (2005). Obesity. Lancet. 366 (9492): 1197–1209.
[4]	Lau, D. C., Douketis, J. D., Morrison, K. M., Hramiak, I. M., Sharma, A. M and Ur, E. (2007). Canadian clinical practice guidelines on the management and prevention of obesity in adults and children summary. Canadan Medical Annual Journal. 176 (8): 1–13.
[5]	Faber, D. R., De Groot, P. G and Visseren F. L. (2009). Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obesity Review. 10 (5): 554–563.
[6]	Vincent, Ricchinti, (2006). Obesity and Inflammation and Thrombotic Factors. Obesity and cardiovascular Disease. 13 (978): 14200–18905.
[7]	Kobayashi, Y., Nihon, R. I., Fukou, Y., Shibuya, T and Terashi, A. (1990). The correlation between the activity of tissue plasminogen activator (TPA), levels of tissue plasminogen activator inhibitor (PAI) antigen and serium lipids in healthy subjects. Internal medicine. Rubmed. 27 (5): 578–583.
[8]	Singh, A., Foster, G. D., Gunawardana, J., Mccoy, T. A., Nguyen, T., Vander, V. S., Komaroff, E. and Rao, A. K. (2012). Elevated Circulating tissue factor VII and plasminogen activator inhibitor in childhood obesity: evidence of a procoagulent state. British Journal of Hematology. 158: 522–527.
[9]	Sudi, K, M., Gallish, S., Weinhandi, G., Mainteau, W and Borkenstein, M. H. (2000). Relationship between plasminogen activator inhibitor 1 antigen, leptin and Fat mass in obese children and adolescents. Metabolism. 49 (7) 890–895.
[10]	Azza, M., Ahmed, N. A., Shdai, H. R., Nehal, S. H., Nevine, E. S and Amany, A. A. (2013). Plasminogen activator inhibitor I in children with central obesity: Effect on left ventricular function. Journal of the Saudi Heart Association. 25 (2) 108.
[11]	Hou, B., Eren, M., Painter, C. A., Covington, J. W., Dixon, J. D., Schoenhard, J. A and Vaughan, D. E. (2004). Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site. Journal Biology Chemistry. 279: 18127–181236.
[12]	Alessi, M. C., Morange, P. and Juhan-Vague, I (2000). Fat cell function and fibrinolysis. Hormone and Metabolic Research. 32: 504–508.
[13]	Hoffman, M., Colina, C. M., McDonald, A. G., Arepally, G., Pedersen, L., Monroe, D. M. (2007). Tissue factor around dermal vessels has been bound factor VII in the absence of injury. Journal of Thrombosis and Hemostasis.: 1403–1408.

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Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime, Zacchaeus Awortu Jeremiah. (2021). Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomedical Sciences, 7(3), 81-85. https://doi.org/10.11648/j.bs.20210703.14

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ACS Style

Kingsley Chukwuka Amaihunwa; Emmanuel Asuquo Etim; Everista Odaburhine Osime; Zacchaeus Awortu Jeremiah. Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomed. Sci. 2021, 7(3), 81-85. doi: 10.11648/j.bs.20210703.14

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AMA Style

Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime, Zacchaeus Awortu Jeremiah. Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomed Sci. 2021;7(3):81-85. doi: 10.11648/j.bs.20210703.14

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@article{10.11648/j.bs.20210703.14,
  author = {Kingsley Chukwuka Amaihunwa and Emmanuel Asuquo Etim and Everista Odaburhine Osime and Zacchaeus Awortu Jeremiah},
  title = {Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria},
  journal = {Biomedical Sciences},
  volume = {7},
  number = {3},
  pages = {81-85},
  doi = {10.11648/j.bs.20210703.14},
  url = {https://doi.org/10.11648/j.bs.20210703.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210703.14},
  abstract = {Background/Objective: Obesity is a medical condition in which adipose tissue accumulates to the extent of having adverse effect on certain procaogulant factors such as: Human Plasminogen Activator Inhibitor (PAI), tissue Plasminogen Activator (t-PA) and Tissue Factor (TF) of adults in Nigeria. This study therefore aims to evaluate the impacts of obesity on PAI, t-PA, and TF in obese adult in Sapele, South-South Nigeria. Materials and Methods: 312 adults with obesity and 103 normal adults (used as controls) with age between 18 and 65 years were enrolled for this study. 4.5mls of venous blood was collected into EDTA containers for procoagulant activity measurement. Human Plasminogen Activator Inhibitor (PAI-1), Human tissue Plasminogen Activator (t-PA), and Human Tissue Factor (TF) values were determined using Enzyme Linked Immunosorbent Assay (ELISA) methods. Collated data was analyzed using Student’s t-test, correlation and one-way ANOVA followed by LSD post-hoc test and results were expressed as mean±standard deviation. Results: The BMI (Body Mass Index) of obese subjects and control subjects were 36.82±0.55kg/m2 and 20.43±0.29 kg/m2 respectively at pConclusion: The values of Plasminogen Activator Inhibitor, tissue Plasminogen Activator, and Human Tissue Factor were higher in people with obesity when compare with non-obese control group in Sapele Southern Nigeria.},
 year = {2021}
}

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TY  - JOUR
T1  - Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria
AU  - Kingsley Chukwuka Amaihunwa
AU  - Emmanuel Asuquo Etim
AU  - Everista Odaburhine Osime
AU  - Zacchaeus Awortu Jeremiah
Y1  - 2021/08/23
PY  - 2021
N1  - https://doi.org/10.11648/j.bs.20210703.14
DO  - 10.11648/j.bs.20210703.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 81
EP  - 85
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20210703.14
AB  - Background/Objective: Obesity is a medical condition in which adipose tissue accumulates to the extent of having adverse effect on certain procaogulant factors such as: Human Plasminogen Activator Inhibitor (PAI), tissue Plasminogen Activator (t-PA) and Tissue Factor (TF) of adults in Nigeria. This study therefore aims to evaluate the impacts of obesity on PAI, t-PA, and TF in obese adult in Sapele, South-South Nigeria. Materials and Methods: 312 adults with obesity and 103 normal adults (used as controls) with age between 18 and 65 years were enrolled for this study. 4.5mls of venous blood was collected into EDTA containers for procoagulant activity measurement. Human Plasminogen Activator Inhibitor (PAI-1), Human tissue Plasminogen Activator (t-PA), and Human Tissue Factor (TF) values were determined using Enzyme Linked Immunosorbent Assay (ELISA) methods. Collated data was analyzed using Student’s t-test, correlation and one-way ANOVA followed by LSD post-hoc test and results were expressed as mean±standard deviation. Results: The BMI (Body Mass Index) of obese subjects and control subjects were 36.82±0.55kg/m2 and 20.43±0.29 kg/m2 respectively at pConclusion: The values of Plasminogen Activator Inhibitor, tissue Plasminogen Activator, and Human Tissue Factor were higher in people with obesity when compare with non-obese control group in Sapele Southern Nigeria.
VL  - 7
IS  - 3
ER  -

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Author Information

Kingsley Chukwuka Amaihunwa

Department of Medical Laboratory Services, General Hospital Oghara, Oghara, Nigeria
Emmanuel Asuquo Etim

Department of Hematology and Blood Transfusion Science, Federal Medical Center Yola, Yola, Nigeria
Everista Odaburhine Osime

Department of Medical Laboratory Science, University of Benin, Benin, Nigeria
Zacchaeus Awortu Jeremiah

Department of Medical Laboratory Science, River State University, Port Harcourt, Nigeria

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APA Style

Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime, Zacchaeus Awortu Jeremiah. (2021). Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomedical Sciences, 7(3), 81-85. https://doi.org/10.11648/j.bs.20210703.14

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ACS Style

Kingsley Chukwuka Amaihunwa; Emmanuel Asuquo Etim; Everista Odaburhine Osime; Zacchaeus Awortu Jeremiah. Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomed. Sci. 2021, 7(3), 81-85. doi: 10.11648/j.bs.20210703.14

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AMA Style

Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime, Zacchaeus Awortu Jeremiah. Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria. Biomed Sci. 2021;7(3):81-85. doi: 10.11648/j.bs.20210703.14

Copy | Download

@article{10.11648/j.bs.20210703.14,
  author = {Kingsley Chukwuka Amaihunwa and Emmanuel Asuquo Etim and Everista Odaburhine Osime and Zacchaeus Awortu Jeremiah},
  title = {Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria},
  journal = {Biomedical Sciences},
  volume = {7},
  number = {3},
  pages = {81-85},
  doi = {10.11648/j.bs.20210703.14},
  url = {https://doi.org/10.11648/j.bs.20210703.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210703.14},
  abstract = {Background/Objective: Obesity is a medical condition in which adipose tissue accumulates to the extent of having adverse effect on certain procaogulant factors such as: Human Plasminogen Activator Inhibitor (PAI), tissue Plasminogen Activator (t-PA) and Tissue Factor (TF) of adults in Nigeria. This study therefore aims to evaluate the impacts of obesity on PAI, t-PA, and TF in obese adult in Sapele, South-South Nigeria. Materials and Methods: 312 adults with obesity and 103 normal adults (used as controls) with age between 18 and 65 years were enrolled for this study. 4.5mls of venous blood was collected into EDTA containers for procoagulant activity measurement. Human Plasminogen Activator Inhibitor (PAI-1), Human tissue Plasminogen Activator (t-PA), and Human Tissue Factor (TF) values were determined using Enzyme Linked Immunosorbent Assay (ELISA) methods. Collated data was analyzed using Student’s t-test, correlation and one-way ANOVA followed by LSD post-hoc test and results were expressed as mean±standard deviation. Results: The BMI (Body Mass Index) of obese subjects and control subjects were 36.82±0.55kg/m2 and 20.43±0.29 kg/m2 respectively at pConclusion: The values of Plasminogen Activator Inhibitor, tissue Plasminogen Activator, and Human Tissue Factor were higher in people with obesity when compare with non-obese control group in Sapele Southern Nigeria.},
 year = {2021}
}

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TY  - JOUR
T1  - Effect of Obesity on Tissue Factor, Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Among Obese People in Sapele Southern Nigeria
AU  - Kingsley Chukwuka Amaihunwa
AU  - Emmanuel Asuquo Etim
AU  - Everista Odaburhine Osime
AU  - Zacchaeus Awortu Jeremiah
Y1  - 2021/08/23
PY  - 2021
N1  - https://doi.org/10.11648/j.bs.20210703.14
DO  - 10.11648/j.bs.20210703.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 81
EP  - 85
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20210703.14
AB  - Background/Objective: Obesity is a medical condition in which adipose tissue accumulates to the extent of having adverse effect on certain procaogulant factors such as: Human Plasminogen Activator Inhibitor (PAI), tissue Plasminogen Activator (t-PA) and Tissue Factor (TF) of adults in Nigeria. This study therefore aims to evaluate the impacts of obesity on PAI, t-PA, and TF in obese adult in Sapele, South-South Nigeria. Materials and Methods: 312 adults with obesity and 103 normal adults (used as controls) with age between 18 and 65 years were enrolled for this study. 4.5mls of venous blood was collected into EDTA containers for procoagulant activity measurement. Human Plasminogen Activator Inhibitor (PAI-1), Human tissue Plasminogen Activator (t-PA), and Human Tissue Factor (TF) values were determined using Enzyme Linked Immunosorbent Assay (ELISA) methods. Collated data was analyzed using Student’s t-test, correlation and one-way ANOVA followed by LSD post-hoc test and results were expressed as mean±standard deviation. Results: The BMI (Body Mass Index) of obese subjects and control subjects were 36.82±0.55kg/m2 and 20.43±0.29 kg/m2 respectively at pConclusion: The values of Plasminogen Activator Inhibitor, tissue Plasminogen Activator, and Human Tissue Factor were higher in people with obesity when compare with non-obese control group in Sapele Southern Nigeria.
VL  - 7
IS  - 3
ER  -

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