Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study

Djingri Labodi Lompo; Nagaonlé Eric Somé; Pegde-bamba Carine Dakouré; Adja Mariam Ouédraogo; Ousséni Diallo; Christian Napon; Jean Kaboré; Athanase Millogo

doi:doi:10.11648/j.cnn.20210504.17

Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study

Djingri Labodi Lompo, Nagaonlé Eric Somé, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, Ousséni Diallo, Christian Napon, Jean Kaboré, Athanase Millogo

Published in Clinical Neurology and Neuroscience (Volume 5, Issue 4)

Received: 4 November 2021 Accepted: 24 November 2021 Published: 3 December 2021

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Abstract

Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/- 24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/- 31 (5 minutes - 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.

Published in	Clinical Neurology and Neuroscience (Volume 5, Issue 4)
DOI	10.11648/j.cnn.20210504.17
Page(s)	117-123
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Status Epilepticus, Etiology, CNS Infections, Strokes, Head Trauma, Ouagadougou

References

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Djingri Labodi Lompo, Nagaonlé Eric Somé, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, Ousséni Diallo, et al. (2021). Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clinical Neurology and Neuroscience, 5(4), 117-123. https://doi.org/10.11648/j.cnn.20210504.17

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Djingri Labodi Lompo; Nagaonlé Eric Somé; Pegde-bamba Carine Dakouré; Adja Mariam Ouédraogo; Ousséni Diallo, et al. Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clin. Neurol. Neurosci. 2021, 5(4), 117-123. doi: 10.11648/j.cnn.20210504.17

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AMA Style

Djingri Labodi Lompo, Nagaonlé Eric Somé, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, Ousséni Diallo, et al. Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clin Neurol Neurosci. 2021;5(4):117-123. doi: 10.11648/j.cnn.20210504.17

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@article{10.11648/j.cnn.20210504.17,
  author = {Djingri Labodi Lompo and Nagaonlé Eric Somé and Pegde-bamba Carine Dakouré and Adja Mariam Ouédraogo and Ousséni Diallo and Christian Napon and Jean Kaboré and Athanase Millogo},
  title = {Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study},
  journal = {Clinical Neurology and Neuroscience},
  volume = {5},
  number = {4},
  pages = {117-123},
  doi = {10.11648/j.cnn.20210504.17},
  url = {https://doi.org/10.11648/j.cnn.20210504.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20210504.17},
  abstract = {Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/- 24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/- 31 (5 minutes - 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.},
 year = {2021}
}

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TY  - JOUR
T1  - Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study
AU  - Djingri Labodi Lompo
AU  - Nagaonlé Eric Somé
AU  - Pegde-bamba Carine Dakouré
AU  - Adja Mariam Ouédraogo
AU  - Ousséni Diallo
AU  - Christian Napon
AU  - Jean Kaboré
AU  - Athanase Millogo
Y1  - 2021/12/03
PY  - 2021
N1  - https://doi.org/10.11648/j.cnn.20210504.17
DO  - 10.11648/j.cnn.20210504.17
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 117
EP  - 123
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20210504.17
AB  - Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/- 24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/- 31 (5 minutes - 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.
VL  - 5
IS  - 4
ER  -

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Author Information

Djingri Labodi Lompo

Health Sciences Training and Research Unit, Tingandogo University Hospital, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Nagaonlé Eric Somé

Department of Medical Biology and Public Health, Health Sciences Research Institute of Ouagadougou, Ouagadougou, Burkina Faso
Pegde-bamba Carine Dakouré

Health Sciences Training and Research Unit, Tingandogo University Hospital, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Adja Mariam Ouédraogo

Department of Medical Biology and Public Health, Health Sciences Research Institute of Ouagadougou, Ouagadougou, Burkina Faso
Ousséni Diallo

Health Sciences Training and Research Unit, Yalgado Ouédraogo University Hospital of Ouagadougou, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Christian Napon

Health Sciences Training and Research Unit, Yalgado Ouédraogo University Hospital of Ouagadougou, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Jean Kaboré

Health Sciences Training and Research Unit, Yalgado Ouédraogo University Hospital of Ouagadougou, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Athanase Millogo

Health Sciences Training and Research Unit, Sour? Sanou University Hospital of Bobo Dioulasso, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

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Djingri Labodi Lompo, Nagaonlé Eric Somé, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, Ousséni Diallo, et al. (2021). Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clinical Neurology and Neuroscience, 5(4), 117-123. https://doi.org/10.11648/j.cnn.20210504.17

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ACS Style

Djingri Labodi Lompo; Nagaonlé Eric Somé; Pegde-bamba Carine Dakouré; Adja Mariam Ouédraogo; Ousséni Diallo, et al. Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clin. Neurol. Neurosci. 2021, 5(4), 117-123. doi: 10.11648/j.cnn.20210504.17

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AMA Style

Djingri Labodi Lompo, Nagaonlé Eric Somé, Pegde-bamba Carine Dakouré, Adja Mariam Ouédraogo, Ousséni Diallo, et al. Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study. Clin Neurol Neurosci. 2021;5(4):117-123. doi: 10.11648/j.cnn.20210504.17

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@article{10.11648/j.cnn.20210504.17,
  author = {Djingri Labodi Lompo and Nagaonlé Eric Somé and Pegde-bamba Carine Dakouré and Adja Mariam Ouédraogo and Ousséni Diallo and Christian Napon and Jean Kaboré and Athanase Millogo},
  title = {Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study},
  journal = {Clinical Neurology and Neuroscience},
  volume = {5},
  number = {4},
  pages = {117-123},
  doi = {10.11648/j.cnn.20210504.17},
  url = {https://doi.org/10.11648/j.cnn.20210504.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20210504.17},
  abstract = {Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/- 24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/- 31 (5 minutes - 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.},
 year = {2021}
}

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TY  - JOUR
T1  - Etiological Spectrum of Status Epilepticus in Ouagadougou, Burkina Faso: A Prospective Cross-sectional Multicenter Hospital Study
AU  - Djingri Labodi Lompo
AU  - Nagaonlé Eric Somé
AU  - Pegde-bamba Carine Dakouré
AU  - Adja Mariam Ouédraogo
AU  - Ousséni Diallo
AU  - Christian Napon
AU  - Jean Kaboré
AU  - Athanase Millogo
Y1  - 2021/12/03
PY  - 2021
N1  - https://doi.org/10.11648/j.cnn.20210504.17
DO  - 10.11648/j.cnn.20210504.17
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 117
EP  - 123
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20210504.17
AB  - Introduction: In sub-Saharan Africa, cerebrovascular aetiologies of status epilepticus (SE) are on the rise alongside infectious brain lesions. The aim of our study was to describe the etiologic spectrum of SE in Ouagadougou, Burkina Faso, in a high risk SE setting. Patients and methods: This is a prospective, cross-sectional, descriptive, multicenter and hospital study of patients hospitalized consecutively in the university hospitals of the city of Ouagadougou, in Burkina Faso, from 01/01/2015 to 12/31/2019, for SE. The sociodemographic, clinical, paraclinical (biological, critical and / or intercritical EEG, neuroradiological) characteristics and the aetiological data of the patients were analyzed using the Epi-info 7.2.1.0 software: calculations of numbers, frequencies, averages. The significance rate was set at 0.05. Results: 91 patients hospitalized for SE were collected, with a male predominance (73.62%). The mean age was 36.6 years +/- 24.5 years (2 days and 86 years); 25 patients (27.5%) already had known epilepsy. Generalized tonic-clonic SE from the start and focal SE with convulsive bilateralization were the most common seizure types with 46 cases (50.5%) and 27 cases (29.7%), respectively. The average duration of an EME episode was 18 hours +/- 31 (5 minutes - 6 days). On admission, a focused motor deficit with 36 cases (46.7%) and fever in 28 patients (30.8%) were the main clinical signs; hyperleukocytosis with 23 cases (25.3) and anemia with 22 cases (24.2%), were the main laboratory abnormalities. On cerebral CT scan, sequelae with 33 cases (51.6%), acute stroke with 14 cases (21.9%) and acute meningoencephalitis with 8 cases (12.5%), were the most frequent. SEs symptomatic of acute brain disease, with 61 cases (67%), were dominated by infectious etiologies with 30 cases (33%) and acute strokes with 16 cases (17.6%). Among the non-acute or sequelae SEs of etiology, the sequelae of traumatic brain injury with 10 cases (11%) and the sequelae of stroke with 8 cases (8.8%) were the most represented. Conclusion: The aetiologies of SE are dominated in the Ouagadougou CHUs by CNS infections, acute or sequelae strokes and cranio-encephalic trauma. The fight against infectious diseases and the prevention of vascular risk factors will help reduce the frequency and severity of EMEs.
VL  - 5
IS  - 4
ER  -

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