Archive:: Journal of Drug Design and Medicinal Chemistry:: Science Publishing Group

Volume 7, Issue 2, June 2021

Identification of APOE4 Modulators, Targeted Therapeutic Candidates in Coronary Artery Disease, Using Molecular Docking Studies

Lima Hazarika, Supriyo Sen, Akshaykumar Zawar, Jitesh Doshi

Issue: Volume 7, Issue 2, June 2021

Pages: 27-38

Received: 23 March 2021

Accepted: 7 April 2021

Published: 20 April 2021

DOI: 10.11648/j.jddmc.20210702.11

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Abstract: Investigate the protein–ligand binding affinity and evaluate the receptor binding abilities of different classes of ligands for APOE4 through molecular docking studies. The polymorphic nature of human Apo E gene encodes one of 3 common epsilon (ε) alleles (ε2, ε3, and ε4), reported to influence the risk of cardiovascular diseases. Structural basis ... Show More

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Establishment of a Method to Allow Microbial Limit Testing of Iodine-containing Preparations

Huang Minna, Tan Fangming, Lin Shaozhu, Liang Zhuanzhi, Qiu Suishan, He Xiaomin

Issue: Volume 7, Issue 2, June 2021

Pages: 39-43

Received: 22 April 2021

Accepted: 17 May 2021

Published: 26 May 2021

DOI: 10.11648/j.jddmc.20210702.12

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Abstract: Background: Contamination of pharmaceuticals with microorganisms may lead to deleterious effects on the therapeutic properties of the drug, and may potentially cause injuries to intended recipients. Iodine can inhibit and kill microorganisms in pharmaceutical preparations. The risk of microbial contamination of cellular products can be reduced when... Show More

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