Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease

Michael Raymond Binder

doi:doi:10.11648/j.ajcem.20221001.11

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Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease

Michael Raymond Binder

Published in American Journal of Clinical and Experimental Medicine (Volume 10, Issue 1)

Received: 23 December 2021 Accepted: 10 January 2022 Published: 20 January 2022

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Abstract

Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent stress is at the root of most psychiatric and general medical conditions. Although this idea is not new, what is new is the identification of a powerful but elusive endogenous driver of the stress. According to the Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by an inherent hyperexcitability of the neurological system. This pathophysiological trait, which appears to be inherited in an autosomal dominant distribution and expressed through the central and peripheral nervous systems, causes shockwaves to be repeatedly sent through the body, keeping it in fight-or-flight mode much or all of the time. The strain that this commonly-occurring trait places on various organs and systems of the body can cause repeated bouts of mental illness and a gradual progression of physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, and dementia. Although the etiology of most illnesses is thought to be multifactorial, the genealogical distribution in which they occur and the relationship that they have to one another strongly suggests that among the various psychological, biological, and environmental factors that contribute to their development, the trait of neuronal hyperexcitability is the most important. This observation has enormous implications because neuronal hyperexcitability is a highly modifiable risk factor. Any psychological, behavioral, dietary, or medical intervention that quiets the nervous system can potentially prevent or delay the development of the various illnesses that are thought to be fueled by the neuronal hyperexcitability trait. In addition, there is emerging evidence that the trait can be detected through resting vital-sign measurements. The ease of this objective measurement and the power that it has to incentivize affected persons to take control of their health underscores the importance of recognizing the connection between neuronal hyperexcitability and the pathogenesis of disease.

Published in	American Journal of Clinical and Experimental Medicine (Volume 10, Issue 1)
DOI	10.11648/j.ajcem.20221001.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Neuronal Hyperexcitability, Biomarkers of Disease, Preventive Medicine, Anticonvulsants, Pathophysiology of Psychiatric Disorders, Genetics of Psychiatric Disorders

References

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[3]	Binder MR. The multi-circuit neuronal hyperexcitability hypothesis of psychiatric disorders. AJCEM 2019; 7 (1): 12-30.
[4]	Binder MR. Neuronal hyperexcitability: Significance, cause, and diversity of clinical expression. AJCEM 2021; 9 (5): 163-173.
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[11]	Farr M, Mathews J, Zhu D-F, Ambron RT. Inflammation causes a long-term hyperexcitability in the nociceptive sensory neurons of Aplysia. Learn Mem 1999; 6 (3): 331–340.
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[18]	Post RM. (2007) Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena. Neuroscience & Biobehavioral Reviews. 31 (6): 858-873.
[19]	Binder MR: The neuronal excitability spectrum: A new paradigm in the diagnosis, treatment, and prevention of mental illness and its relation to chronic disease. AJCEM; 2021; 9 (6): 187-203.
[20]	Latvala A, Kuja-Halkola R, Rick C, et al. Association of resting heart rate and blood pressure in late adolescence with subsequent mental disorders: A longitudinal population study of more than 1 million men in Sweden. JAMA Psychiatry 2016; 73 (12): 1268-1275.
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Michael Raymond Binder. (2022). Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. American Journal of Clinical and Experimental Medicine, 10(1), 1-7. https://doi.org/10.11648/j.ajcem.20221001.11

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Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. Am. J. Clin. Exp. Med. 2022, 10(1), 1-7. doi: 10.11648/j.ajcem.20221001.11

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AMA Style

Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. Am J Clin Exp Med. 2022;10(1):1-7. doi: 10.11648/j.ajcem.20221001.11

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@article{10.11648/j.ajcem.20221001.11,
  author = {Michael Raymond Binder},
  title = {Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajcem.20221001.11},
  url = {https://doi.org/10.11648/j.ajcem.20221001.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221001.11},
  abstract = {Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent stress is at the root of most psychiatric and general medical conditions. Although this idea is not new, what is new is the identification of a powerful but elusive endogenous driver of the stress. According to the Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by an inherent hyperexcitability of the neurological system. This pathophysiological trait, which appears to be inherited in an autosomal dominant distribution and expressed through the central and peripheral nervous systems, causes shockwaves to be repeatedly sent through the body, keeping it in fight-or-flight mode much or all of the time. The strain that this commonly-occurring trait places on various organs and systems of the body can cause repeated bouts of mental illness and a gradual progression of physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, and dementia. Although the etiology of most illnesses is thought to be multifactorial, the genealogical distribution in which they occur and the relationship that they have to one another strongly suggests that among the various psychological, biological, and environmental factors that contribute to their development, the trait of neuronal hyperexcitability is the most important. This observation has enormous implications because neuronal hyperexcitability is a highly modifiable risk factor. Any psychological, behavioral, dietary, or medical intervention that quiets the nervous system can potentially prevent or delay the development of the various illnesses that are thought to be fueled by the neuronal hyperexcitability trait. In addition, there is emerging evidence that the trait can be detected through resting vital-sign measurements. The ease of this objective measurement and the power that it has to incentivize affected persons to take control of their health underscores the importance of recognizing the connection between neuronal hyperexcitability and the pathogenesis of disease.},
 year = {2022}
}

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TY  - JOUR
T1  - Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease
AU  - Michael Raymond Binder
Y1  - 2022/01/20
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221001.11
DO  - 10.11648/j.ajcem.20221001.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221001.11
AB  - Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent stress is at the root of most psychiatric and general medical conditions. Although this idea is not new, what is new is the identification of a powerful but elusive endogenous driver of the stress. According to the Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by an inherent hyperexcitability of the neurological system. This pathophysiological trait, which appears to be inherited in an autosomal dominant distribution and expressed through the central and peripheral nervous systems, causes shockwaves to be repeatedly sent through the body, keeping it in fight-or-flight mode much or all of the time. The strain that this commonly-occurring trait places on various organs and systems of the body can cause repeated bouts of mental illness and a gradual progression of physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, and dementia. Although the etiology of most illnesses is thought to be multifactorial, the genealogical distribution in which they occur and the relationship that they have to one another strongly suggests that among the various psychological, biological, and environmental factors that contribute to their development, the trait of neuronal hyperexcitability is the most important. This observation has enormous implications because neuronal hyperexcitability is a highly modifiable risk factor. Any psychological, behavioral, dietary, or medical intervention that quiets the nervous system can potentially prevent or delay the development of the various illnesses that are thought to be fueled by the neuronal hyperexcitability trait. In addition, there is emerging evidence that the trait can be detected through resting vital-sign measurements. The ease of this objective measurement and the power that it has to incentivize affected persons to take control of their health underscores the importance of recognizing the connection between neuronal hyperexcitability and the pathogenesis of disease.
VL  - 10
IS  - 1
ER  -

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Author Information

Michael Raymond Binder

Highland Park Hospital, North Shore University Health System, Highland Park, USA

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Michael Raymond Binder. (2022). Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. American Journal of Clinical and Experimental Medicine, 10(1), 1-7. https://doi.org/10.11648/j.ajcem.20221001.11

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ACS Style

Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. Am. J. Clin. Exp. Med. 2022, 10(1), 1-7. doi: 10.11648/j.ajcem.20221001.11

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AMA Style

Michael Raymond Binder. Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease. Am J Clin Exp Med. 2022;10(1):1-7. doi: 10.11648/j.ajcem.20221001.11

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@article{10.11648/j.ajcem.20221001.11,
  author = {Michael Raymond Binder},
  title = {Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {10},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajcem.20221001.11},
  url = {https://doi.org/10.11648/j.ajcem.20221001.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20221001.11},
  abstract = {Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent stress is at the root of most psychiatric and general medical conditions. Although this idea is not new, what is new is the identification of a powerful but elusive endogenous driver of the stress. According to the Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by an inherent hyperexcitability of the neurological system. This pathophysiological trait, which appears to be inherited in an autosomal dominant distribution and expressed through the central and peripheral nervous systems, causes shockwaves to be repeatedly sent through the body, keeping it in fight-or-flight mode much or all of the time. The strain that this commonly-occurring trait places on various organs and systems of the body can cause repeated bouts of mental illness and a gradual progression of physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, and dementia. Although the etiology of most illnesses is thought to be multifactorial, the genealogical distribution in which they occur and the relationship that they have to one another strongly suggests that among the various psychological, biological, and environmental factors that contribute to their development, the trait of neuronal hyperexcitability is the most important. This observation has enormous implications because neuronal hyperexcitability is a highly modifiable risk factor. Any psychological, behavioral, dietary, or medical intervention that quiets the nervous system can potentially prevent or delay the development of the various illnesses that are thought to be fueled by the neuronal hyperexcitability trait. In addition, there is emerging evidence that the trait can be detected through resting vital-sign measurements. The ease of this objective measurement and the power that it has to incentivize affected persons to take control of their health underscores the importance of recognizing the connection between neuronal hyperexcitability and the pathogenesis of disease.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease
AU  - Michael Raymond Binder
Y1  - 2022/01/20
PY  - 2022
N1  - https://doi.org/10.11648/j.ajcem.20221001.11
DO  - 10.11648/j.ajcem.20221001.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20221001.11
AB  - Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent stress is at the root of most psychiatric and general medical conditions. Although this idea is not new, what is new is the identification of a powerful but elusive endogenous driver of the stress. According to the Multi-Circuit Neuronal Hyperexcitability (MCNH) hypothesis, ordinary daily stressors are abnormally amplified by an inherent hyperexcitability of the neurological system. This pathophysiological trait, which appears to be inherited in an autosomal dominant distribution and expressed through the central and peripheral nervous systems, causes shockwaves to be repeatedly sent through the body, keeping it in fight-or-flight mode much or all of the time. The strain that this commonly-occurring trait places on various organs and systems of the body can cause repeated bouts of mental illness and a gradual progression of physical illnesses such as diabetes mellitus, high blood pressure, cardiovascular disease, autoimmune diseases, cancer, and dementia. Although the etiology of most illnesses is thought to be multifactorial, the genealogical distribution in which they occur and the relationship that they have to one another strongly suggests that among the various psychological, biological, and environmental factors that contribute to their development, the trait of neuronal hyperexcitability is the most important. This observation has enormous implications because neuronal hyperexcitability is a highly modifiable risk factor. Any psychological, behavioral, dietary, or medical intervention that quiets the nervous system can potentially prevent or delay the development of the various illnesses that are thought to be fueled by the neuronal hyperexcitability trait. In addition, there is emerging evidence that the trait can be detected through resting vital-sign measurements. The ease of this objective measurement and the power that it has to incentivize affected persons to take control of their health underscores the importance of recognizing the connection between neuronal hyperexcitability and the pathogenesis of disease.
VL  - 10
IS  - 1
ER  -

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