Ameliorative Effect of <i>Moringa Oleifera</i> Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez; Halima Ibrahim Yusuf; Aliyu Habeeb Tosin; Nicholas Nathaniel Pilau; Adamu Abdul Abubakar; Muhammad Bashir Bello Muhammad Bashir Bello

doi:doi:10.11648/j.ab.20210901.12

Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, Halima Ibrahim Yusuf, Aliyu Habeeb Tosin, Nicholas Nathaniel Pilau, Adamu Abdul Abubakar, Muhammad Bashir Bello Muhammad Bashir Bello

Published in Advances in Biochemistry (Volume 9, Issue 1)

Received: 19 March 2020 Accepted: 11 May 2020 Published: 23 February 2021

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Abstract

Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.

Published in	Advances in Biochemistry (Volume 9, Issue 1)
DOI	10.11648/j.ab.20210901.12
Page(s)	6-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ameliorative, Diabetes, Leaf Extract, Medicinal Plants, Moringa oleifera, Streptozocin, Wistar Rats

References

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[7]	Pasquel, F. J., Tsegka, K., Wang, H., Cardona, S., Galindo, R. J., Fayfman, M.,... & Narayan, K. V., Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study. 349-357. Diabetes Care 2020. 43 (2).
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[11]	Farid, A. S., & Hegazy, A. M., Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats Drug and chemical toxicolog 2019 48 (1): p. 345-55.
[12]	Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L., Bioactive components in Moringa Oleifera leaves protect against chronic disease. Antioxidants 2017 6 (4): p. 91.
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[14]	Mostafavinia, A., Amini, A., Ghorishi, S. K., Pouriran, R., & Bayat, M., The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of typel diabetes mellitus and mortality rate in rats.. Laboratory animal research,, 2016. 32 (3): p. 160-165.
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APA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Advances in Biochemistry, 9(1), 6-10. https://doi.org/10.11648/j.ab.20210901.12

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ACS Style

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv. Biochem. 2021, 9(1), 6-10. doi: 10.11648/j.ab.20210901.12

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AMA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv Biochem. 2021;9(1):6-10. doi: 10.11648/j.ab.20210901.12

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@article{10.11648/j.ab.20210901.12,
  author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Aliyu Habeeb Tosin and Nicholas Nathaniel Pilau and Adamu Abdul Abubakar and Muhammad Bashir Bello Muhammad Bashir Bello},
  title = {Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats},
  journal = {Advances in Biochemistry},
  volume = {9},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ab.20210901.12},
  url = {https://doi.org/10.11648/j.ab.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20210901.12},
  abstract = {Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.},
 year = {2021}
}

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TY  - JOUR
T1  - Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats
AU  - Ibrahim Maina Hassan
AU  - Bashir Saidu
AU  - Ja’afaru Abdullahi Ishaq
AU  - Ashiru Dahiru
AU  - Nafisat Abdulazeez
AU  - Halima Ibrahim Yusuf
AU  - Aliyu Habeeb Tosin
AU  - Nicholas Nathaniel Pilau
AU  - Adamu Abdul Abubakar
AU  - Muhammad Bashir Bello Muhammad Bashir Bello
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ab.20210901.12
DO  - 10.11648/j.ab.20210901.12
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20210901.12
AB  - Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.
VL  - 9
IS  - 1
ER  -

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Author Information

Ibrahim Maina Hassan

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Bashir Saidu

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Ja’afaru Abdullahi Ishaq

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Ashiru Dahiru

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Nafisat Abdulazeez

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Halima Ibrahim Yusuf

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Aliyu Habeeb Tosin

Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Nicholas Nathaniel Pilau

Department of Veterinary Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Adamu Abdul Abubakar

Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria
Muhammad Bashir Bello Muhammad Bashir Bello

Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

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Plain Text BibTeX RIS

APA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Advances in Biochemistry, 9(1), 6-10. https://doi.org/10.11648/j.ab.20210901.12

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ACS Style

Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv. Biochem. 2021, 9(1), 6-10. doi: 10.11648/j.ab.20210901.12

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AMA Style

Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv Biochem. 2021;9(1):6-10. doi: 10.11648/j.ab.20210901.12

Copy | Download

@article{10.11648/j.ab.20210901.12,
  author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Aliyu Habeeb Tosin and Nicholas Nathaniel Pilau and Adamu Abdul Abubakar and Muhammad Bashir Bello Muhammad Bashir Bello},
  title = {Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats},
  journal = {Advances in Biochemistry},
  volume = {9},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.ab.20210901.12},
  url = {https://doi.org/10.11648/j.ab.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20210901.12},
  abstract = {Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.},
 year = {2021}
}

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TY  - JOUR
T1  - Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats
AU  - Ibrahim Maina Hassan
AU  - Bashir Saidu
AU  - Ja’afaru Abdullahi Ishaq
AU  - Ashiru Dahiru
AU  - Nafisat Abdulazeez
AU  - Halima Ibrahim Yusuf
AU  - Aliyu Habeeb Tosin
AU  - Nicholas Nathaniel Pilau
AU  - Adamu Abdul Abubakar
AU  - Muhammad Bashir Bello Muhammad Bashir Bello
Y1  - 2021/02/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ab.20210901.12
DO  - 10.11648/j.ab.20210901.12
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20210901.12
AB  - Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.
VL  - 9
IS  - 1
ER  -

Copy | Download