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Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein

Received: 4 July 2016     Accepted: 22 July 2016     Published: 22 August 2016
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Abstract

Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.

Published in Biomedical Sciences (Volume 2, Issue 3)
DOI 10.11648/j.bs.20160203.11
Page(s) 16-23
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Post-Transcriptional Regulation, MicroRNA, RNA-Binding Protein, Knockout Mice

References
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    Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. (2016). Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomedical Sciences, 2(3), 16-23. https://doi.org/10.11648/j.bs.20160203.11

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    Tomoki Chiba; Yoshiaki Ito; Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed. Sci. 2016, 2(3), 16-23. doi: 10.11648/j.bs.20160203.11

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    AMA Style

    Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomed Sci. 2016;2(3):16-23. doi: 10.11648/j.bs.20160203.11

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  • @article{10.11648/j.bs.20160203.11,
      author = {Tomoki Chiba and Yoshiaki Ito and Hiroshi Asahara},
      title = {Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein},
      journal = {Biomedical Sciences},
      volume = {2},
      number = {3},
      pages = {16-23},
      doi = {10.11648/j.bs.20160203.11},
      url = {https://doi.org/10.11648/j.bs.20160203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20160203.11},
      abstract = {Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein
    AU  - Tomoki Chiba
    AU  - Yoshiaki Ito
    AU  - Hiroshi Asahara
    Y1  - 2016/08/22
    PY  - 2016
    N1  - https://doi.org/10.11648/j.bs.20160203.11
    DO  - 10.11648/j.bs.20160203.11
    T2  - Biomedical Sciences
    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
    SP  - 16
    EP  - 23
    PB  - Science Publishing Group
    SN  - 2575-3932
    UR  - https://doi.org/10.11648/j.bs.20160203.11
    AB  - Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

  • Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

  • Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

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