International Journal of Pharmacy and Chemistry

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Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes

Received: Aug. 30, 2023    Accepted: Sep. 21, 2023    Published: Oct. 08, 2023
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Abstract

Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes.

DOI 10.11648/j.ijpc.20230905.11
Published in International Journal of Pharmacy and Chemistry ( Volume 9, Issue 5, September 2023 )
Page(s) 56-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Phytochemical Analysis, Anti-Diabetic, Antioxidant Potential, Hydro-Ethanolic Extracts

References
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  • APA Style

    Simplice Koudjina, Alban Gouton Houngbeme, Israël Dossou Paulin Agbogba, Guy Yacolé Sylvain Atohoun, Joachim Djimon Gbenou. (2023). Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. International Journal of Pharmacy and Chemistry, 9(5), 56-66. https://doi.org/10.11648/j.ijpc.20230905.11

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    ACS Style

    Simplice Koudjina; Alban Gouton Houngbeme; Israël Dossou Paulin Agbogba; Guy Yacolé Sylvain Atohoun; Joachim Djimon Gbenou. Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. Int. J. Pharm. Chem. 2023, 9(5), 56-66. doi: 10.11648/j.ijpc.20230905.11

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    AMA Style

    Simplice Koudjina, Alban Gouton Houngbeme, Israël Dossou Paulin Agbogba, Guy Yacolé Sylvain Atohoun, Joachim Djimon Gbenou. Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes. Int J Pharm Chem. 2023;9(5):56-66. doi: 10.11648/j.ijpc.20230905.11

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  • @article{10.11648/j.ijpc.20230905.11,
      author = {Simplice Koudjina and Alban Gouton Houngbeme and Israël Dossou Paulin Agbogba and Guy Yacolé Sylvain Atohoun and Joachim Djimon Gbenou},
      title = {Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {9},
      number = {5},
      pages = {56-66},
      doi = {10.11648/j.ijpc.20230905.11},
      url = {https://doi.org/10.11648/j.ijpc.20230905.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijpc.20230905.11},
      abstract = {Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Phytochemical Analysis and Bioactivities Studies of Fresh Leaves and Flowers from C. roseus, L. multiflora and P. amarus, Beninese Medicinal Plants Used Against Diabetes
    AU  - Simplice Koudjina
    AU  - Alban Gouton Houngbeme
    AU  - Israël Dossou Paulin Agbogba
    AU  - Guy Yacolé Sylvain Atohoun
    AU  - Joachim Djimon Gbenou
    Y1  - 2023/10/08
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijpc.20230905.11
    DO  - 10.11648/j.ijpc.20230905.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 56
    EP  - 66
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20230905.11
    AB  - Traditional herbal medicines make up a large part of drug use. This work addressed an area of public health, the fight against diabetes. The present study aimed to carry out qualitative and quantitative screening of the secondary metabolites of extracts from the leaves and flowers of plants such as Catharanthus roseus, Lippia multiflora and Phyllanthus amarus, and to evaluate the antioxidant activity in their aqueous and ethanolic extracts, their larval toxicity and then to predict the antidiabetic activity. The results showed that its plants have in their various extracts some secondary metabolites such as alkaloids, tannins, flavonoids, coumarins, terpenoids, phenolic compounds, steroids, etc responsible for several interesting pharmaceutical activities. These medicinal plants showed a higher quantity of polyphenols in the hydro-ethanolic extracts, with levels of 60.65±0.13; 44.40±1.43 and 67.11±0.39 mg.eq/g respectively for C. roseus, L. multiflora and P. amarus and also a higher antioxidant potential for L. multiflora and P. amarus than the standard Vitamin C, with IC50 equal to 0.53 and 0.52 mg/mL respectively. Extracts are not toxic against larvae. These results are an important indicator of the hypoglycemic and anti-diabetic activity and confirmed the potential for use of these plants by the population in the fight against diabetes.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Laboratory of Medical Biotechnology and Pharmaceutical Research (LaRBiMeP), National High School of Applied Biosciences and Biotechnologies (ENSBBA), National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM), Abomey, Benin; Laboratory of Chemical Physics-Materials and Molecular Modeling (LCP3M), University of Abomey-Calavi (UAC), Abomey-Calavi, Benin

  • Laboratory of Pharmaceutical Organic Chemistry, UFR Pharmacy, Faculty of Health Sciences, University of Abomey-Calavi (UAC), Abomey-Calavi, Benin

  • Laboratory of Medical Biotechnology and Pharmaceutical Research (LaRBiMeP), National High School of Applied Biosciences and Biotechnologies (ENSBBA), National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM), Abomey, Benin

  • Laboratory of Chemical Physics-Materials and Molecular Modeling (LCP3M), University of Abomey-Calavi (UAC), Abomey-Calavi, Benin

  • Laboratory Pharmacognosies and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Abomey-Calavi, Benin

  • Section