Research Article
Phytochemical Constituents and Haematological Profile of Female Rats Following Oral Administration of Aqueous Extract of Tetrapleura Tetraptera Fruits
Issue:
Volume 12, Issue 4, August 2026
Pages:
41-46
Received:
25 November 2025
Accepted:
29 December 2025
Published:
23 October 2026
DOI:
10.11648/j.ijpc.20261204.11
Downloads:
Views:
Abstract: The phytochemical screening and the effect of administration of aqueous extract of T. tetraptera fruits at the doses of 50, 100 and 150 mg/kg body weight on daily basis for 14 days on haematological profile of female Albino rats was investigated. Female albino rats weighing 90g-125g were grouped into four (1-4) such that animals in group 1 received 0.5 ml of normal saline as a placebo while those in groups 2, 3, and 4 received same volume of the extract corresponding to 50, 100 and 150 mg/kg body weight respectively. The extract contained saponins (3.87%), phytosterols (9.89%), tannins (2.34%), phenols (7.08%), flavonoids (13.11%), cardiac glycosides (2.48%), terpenoids (8.92%) while alkaloids and anthraquinones were absent. All the doses of the extract significantly decreased (p<0.05) the levels of haemoglobin (Hb) and Packed Cell Volume (PCV). In contrast, the levels of Total White Blood Cell (TWBC), Mean Corpuscular Haemoglobin (MCH) and Mean Corpuscular Haemoglobin Concentration (MCHC) increased significantly (P<0.05). While the levels of Red Blood Cell (RBC), Platelet (PLT) and Mean Corpuscular Volume (MCV) were not significantly altered (p<0.05) by all the doses of the extract, there was dose specific effects on the neutrophils, lymphocytes, monocytes and eosinophils of the animals without any significant alteration in their levels. Findings from this study have revealed that the administration of the aqueous extract of T. tetraptera fruits at the doses of 50, 100 and 150 mg/kg body weight once daily for 14 days selectively and mildly altered the levels of haematological parameters in the experimental animals.
Abstract: The phytochemical screening and the effect of administration of aqueous extract of T. tetraptera fruits at the doses of 50, 100 and 150 mg/kg body weight on daily basis for 14 days on haematological profile of female Albino rats was investigated. Female albino rats weighing 90g-125g were grouped into four (1-4) such that animals in group 1 received...
Show More
,
Friday Obinwa Uhegbu
