Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.
| Published in | Pharmaceutical Science and Technology (Volume 6, Issue 2) |
| DOI | 10.11648/j.pst.20220602.12 |
| Page(s) | 26-29 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Agarwood, Recurrent Aphthous Ulcer, Sesquiterpene, Pain, Neurotransmitter
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APA Style
Si-Yu Tao, Jing-Kai Fu, Sunchuri Diwas, Yi-Nan Zhang, Nan Wang, et al. (2022). Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharmaceutical Science and Technology, 6(2), 26-29. https://doi.org/10.11648/j.pst.20220602.12
ACS Style
Si-Yu Tao; Jing-Kai Fu; Sunchuri Diwas; Yi-Nan Zhang; Nan Wang, et al. Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharm. Sci. Technol. 2022, 6(2), 26-29. doi: 10.11648/j.pst.20220602.12
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Download@article{10.11648/j.pst.20220602.12,
author = {Si-Yu Tao and Jing-Kai Fu and Sunchuri Diwas and Yi-Nan Zhang and Nan Wang and Yao Yao and Fan-Di Xu and Yang Lin and Zhu-Ling Guo},
title = {Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer},
journal = {Pharmaceutical Science and Technology},
volume = {6},
number = {2},
pages = {26-29},
doi = {10.11648/j.pst.20220602.12},
url = {https://doi.org/10.11648/j.pst.20220602.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20220602.12},
abstract = {Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.},
year = {2022}
}
TY - JOUR T1 - Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer AU - Si-Yu Tao AU - Jing-Kai Fu AU - Sunchuri Diwas AU - Yi-Nan Zhang AU - Nan Wang AU - Yao Yao AU - Fan-Di Xu AU - Yang Lin AU - Zhu-Ling Guo Y1 - 2022/11/29 PY - 2022 N1 - https://doi.org/10.11648/j.pst.20220602.12 DO - 10.11648/j.pst.20220602.12 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 26 EP - 29 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20220602.12 AB - Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU. VL - 6 IS - 2 ER -
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