This study aimed to compare Xellia Pharmaceuticals’ Vanco Ready® Vancomycin Injection, a premix, room-temperature stable vancomycin IV formulation, with compounded lyophilized vancomycin in a simulated sterile compounding setting, to assess dispensing time and dosing accuracy. Twelve simulations were performed to compare Vanco Ready® Vancomycin Injection premix, room-temperature formulation to single-dose, immediate-use compounded IV vancomycin and to multi-dose, batch compounded IV vancomycin. The first part of the study involved assessing the total dispensing time (i.e., time Rx order is received to when product is available for administration), which also included the compounding time required for the single-dose and batch-compounded, lyophilized products. The second component of the study involved measuring dosing accuracy, a composite of the diluent volumes needed for reconstitution and the residual drug volumes remaining in the vials, after the prescribed dose was removed. Vanco Ready® Vancomycin Injection premix was statistically better than single-dose, immediate-use compounded product and batch-compounded product for both dispensing time and dosing accuracy (p<0.05). The total dispensing time for Vanco Ready® Vancomycin Injection premix was an average of 1 minute/37 seconds compared to the total dispensing time for the single-dose, immediate-use compounded product, 20 minutes/28 seconds, and the batch-compounded product (8 bags) 28 minutes/7 seconds (average of 3 minutes/17 seconds per bag), which were inclusive of product verification and compounding times. Based on the total dispensing time, there was a statistical difference (p<0.05) between the total dispensing time for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. The dose accuracy for Vanco Ready® Vancomycin Injection premix was assumed to be 100%, due to the rigorous, quality controls in place for commercially manufactured premix medications. The dosing accuracy of the single-dose, immediate-use compounded product was 91.20% and the dosing accuracy of batch-compounded product was 84.32%. Based on the dosing accuracy, there was a statistical difference (p<0.05) between the overall dose accuracy for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. Vanco Ready® Vancomycin Injection premix showed a statistical improvement in the total dispensing time and dosing accuracy when compared to single-dose, immediate-use compounded product and batch compounded product. The results of this study indicate that commercially manufactured Vanco Ready® Vancomycin Injection may be a viable alternative over pharmacy compounded, lyophilized vancomycin, for healthcare institutions to consider for non-pregnant patients.
| Published in | Pharmaceutical Science and Technology (Volume 7, Issue 1) |
| DOI | 10.11648/j.pst.20230701.13 |
| Page(s) | 13-19 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Clinical Simulation, Compounding, Dispensing Time, Dose Accuracy, Error Reduction, Vanco Ready® Vancomycin Injection, Premix, Ready-to-Use
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| [7] | USP. <797> PHARMACEUTICAL COMPOUNDING — STERILE PREPARATIONS. |
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APA Style
Alexander James Sperry, James Cruikshank, Huong Hoang, Kato Nichols, George Edward MacKinnon III, et al. (2023). Comparison of Vanco Ready® Vancomycin Injection Premix with Lyophilized Vancomycin Products in a Simulated Compounding & Clinical Setting. Pharmaceutical Science and Technology, 7(1), 13-19. https://doi.org/10.11648/j.pst.20230701.13
ACS Style
Alexander James Sperry; James Cruikshank; Huong Hoang; Kato Nichols; George Edward MacKinnon III, et al. Comparison of Vanco Ready® Vancomycin Injection Premix with Lyophilized Vancomycin Products in a Simulated Compounding & Clinical Setting. Pharm. Sci. Technol. 2023, 7(1), 13-19. doi: 10.11648/j.pst.20230701.13
AMA Style
Alexander James Sperry, James Cruikshank, Huong Hoang, Kato Nichols, George Edward MacKinnon III, et al. Comparison of Vanco Ready® Vancomycin Injection Premix with Lyophilized Vancomycin Products in a Simulated Compounding & Clinical Setting. Pharm Sci Technol. 2023;7(1):13-19. doi: 10.11648/j.pst.20230701.13
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author = {Alexander James Sperry and James Cruikshank and Huong Hoang and Kato Nichols and George Edward MacKinnon III and Nashaat Zakaria Gerges and Abhay Singh Chauhan},
title = {Comparison of Vanco Ready® Vancomycin Injection Premix with Lyophilized Vancomycin Products in a Simulated Compounding & Clinical Setting},
journal = {Pharmaceutical Science and Technology},
volume = {7},
number = {1},
pages = {13-19},
doi = {10.11648/j.pst.20230701.13},
url = {https://doi.org/10.11648/j.pst.20230701.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20230701.13},
abstract = {This study aimed to compare Xellia Pharmaceuticals’ Vanco Ready® Vancomycin Injection, a premix, room-temperature stable vancomycin IV formulation, with compounded lyophilized vancomycin in a simulated sterile compounding setting, to assess dispensing time and dosing accuracy. Twelve simulations were performed to compare Vanco Ready® Vancomycin Injection premix, room-temperature formulation to single-dose, immediate-use compounded IV vancomycin and to multi-dose, batch compounded IV vancomycin. The first part of the study involved assessing the total dispensing time (i.e., time Rx order is received to when product is available for administration), which also included the compounding time required for the single-dose and batch-compounded, lyophilized products. The second component of the study involved measuring dosing accuracy, a composite of the diluent volumes needed for reconstitution and the residual drug volumes remaining in the vials, after the prescribed dose was removed. Vanco Ready® Vancomycin Injection premix was statistically better than single-dose, immediate-use compounded product and batch-compounded product for both dispensing time and dosing accuracy (p<0.05). The total dispensing time for Vanco Ready® Vancomycin Injection premix was an average of 1 minute/37 seconds compared to the total dispensing time for the single-dose, immediate-use compounded product, 20 minutes/28 seconds, and the batch-compounded product (8 bags) 28 minutes/7 seconds (average of 3 minutes/17 seconds per bag), which were inclusive of product verification and compounding times. Based on the total dispensing time, there was a statistical difference (p<0.05) between the total dispensing time for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. The dose accuracy for Vanco Ready® Vancomycin Injection premix was assumed to be 100%, due to the rigorous, quality controls in place for commercially manufactured premix medications. The dosing accuracy of the single-dose, immediate-use compounded product was 91.20% and the dosing accuracy of batch-compounded product was 84.32%. Based on the dosing accuracy, there was a statistical difference (p<0.05) between the overall dose accuracy for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. Vanco Ready® Vancomycin Injection premix showed a statistical improvement in the total dispensing time and dosing accuracy when compared to single-dose, immediate-use compounded product and batch compounded product. The results of this study indicate that commercially manufactured Vanco Ready® Vancomycin Injection may be a viable alternative over pharmacy compounded, lyophilized vancomycin, for healthcare institutions to consider for non-pregnant patients.},
year = {2023}
}
TY - JOUR T1 - Comparison of Vanco Ready® Vancomycin Injection Premix with Lyophilized Vancomycin Products in a Simulated Compounding & Clinical Setting AU - Alexander James Sperry AU - James Cruikshank AU - Huong Hoang AU - Kato Nichols AU - George Edward MacKinnon III AU - Nashaat Zakaria Gerges AU - Abhay Singh Chauhan Y1 - 2023/07/06 PY - 2023 N1 - https://doi.org/10.11648/j.pst.20230701.13 DO - 10.11648/j.pst.20230701.13 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 13 EP - 19 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20230701.13 AB - This study aimed to compare Xellia Pharmaceuticals’ Vanco Ready® Vancomycin Injection, a premix, room-temperature stable vancomycin IV formulation, with compounded lyophilized vancomycin in a simulated sterile compounding setting, to assess dispensing time and dosing accuracy. Twelve simulations were performed to compare Vanco Ready® Vancomycin Injection premix, room-temperature formulation to single-dose, immediate-use compounded IV vancomycin and to multi-dose, batch compounded IV vancomycin. The first part of the study involved assessing the total dispensing time (i.e., time Rx order is received to when product is available for administration), which also included the compounding time required for the single-dose and batch-compounded, lyophilized products. The second component of the study involved measuring dosing accuracy, a composite of the diluent volumes needed for reconstitution and the residual drug volumes remaining in the vials, after the prescribed dose was removed. Vanco Ready® Vancomycin Injection premix was statistically better than single-dose, immediate-use compounded product and batch-compounded product for both dispensing time and dosing accuracy (p<0.05). The total dispensing time for Vanco Ready® Vancomycin Injection premix was an average of 1 minute/37 seconds compared to the total dispensing time for the single-dose, immediate-use compounded product, 20 minutes/28 seconds, and the batch-compounded product (8 bags) 28 minutes/7 seconds (average of 3 minutes/17 seconds per bag), which were inclusive of product verification and compounding times. Based on the total dispensing time, there was a statistical difference (p<0.05) between the total dispensing time for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. The dose accuracy for Vanco Ready® Vancomycin Injection premix was assumed to be 100%, due to the rigorous, quality controls in place for commercially manufactured premix medications. The dosing accuracy of the single-dose, immediate-use compounded product was 91.20% and the dosing accuracy of batch-compounded product was 84.32%. Based on the dosing accuracy, there was a statistical difference (p<0.05) between the overall dose accuracy for Vanco Ready® compared to single-dose, immediate-use compounded product, and compared to the batch compounded product average. Vanco Ready® Vancomycin Injection premix showed a statistical improvement in the total dispensing time and dosing accuracy when compared to single-dose, immediate-use compounded product and batch compounded product. The results of this study indicate that commercially manufactured Vanco Ready® Vancomycin Injection may be a viable alternative over pharmacy compounded, lyophilized vancomycin, for healthcare institutions to consider for non-pregnant patients. VL - 7 IS - 1 ER -
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