Research Article
Study of the Bioavailability of Methyluracil in Vitro and Its Biocompatibility in Vivo in the Composition of Polyurethane Implant Material
Issue:
Volume 11, Issue 1, March 2025
Pages:
1-6
Received:
17 July 2025
Accepted:
4 August 2025
Published:
20 August 2025
Abstract: The development of polymer implant materials for use as drug carriers is an urgent task today. The aim of this work was to study the bioavailability of methyluracil when immobilized on a polyurethane carrier in vitro, as well as to study the biocompatibility of the obtained material when conducting model operations on experimental animals in vivo. As a result of the conducted studies, it was shown that the bioavailability of methyluracil immobilized on a polyurethane carrier is 78.5%, its prolonged release into the model environment is observed for 84 days. At the same time, more than 50% of the injected methyluracil was released by the 14th day of the study, which can significantly contribute to increasing the efficiency of regenerative processes at the implantation site, especially in the initial stages of the postoperative period. The conducted model operations on experimental animals made it possible to establish that the developed composite material with methyluracil is biocompatible and bioactive. Implantation of polymer samples with prolonged release of methyluracil contributed to the reduction of alteration and exudation phenomena in the implant placement area, activation of regeneration processes, and the formation of a mature and thin capsule around the implant already in the early stages of the study.
Abstract: The development of polymer implant materials for use as drug carriers is an urgent task today. The aim of this work was to study the bioavailability of methyluracil when immobilized on a polyurethane carrier in vitro, as well as to study the biocompatibility of the obtained material when conducting model operations on experimental animals in vivo. ...
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Review Article
Innovative Pathways in Chemical Science: Conducting Polymers at the Forefront
Ravuri Hema Krishna*
Issue:
Volume 11, Issue 1, March 2025
Pages:
7-14
Received:
23 August 2025
Accepted:
3 September 2025
Published:
25 September 2025
Abstract: Conducting polymers (CPs) represent a unique class of organic materials that combine the electronic and optical properties of metals or semiconductors with the mechanical flexibility and processability of conventional polymers. Conducting polymers are organic polymers that conduct electricity due to conjugated double bonds and doping, offering properties similar to metals and semiconductors but with enhanced flexibility and processability. Since the discovery of polyacetylene’s conductivity upon doping, a wide range of conducting polymers such as polyaniline (PANI), polypyrrole (PPy), polythiophene (PTh), and their derivatives have been extensively studied. Their electrical conductivity arises from conjugated π-electron systems, which can be modulated through chemical or electrochemical doping. These materials exhibit remarkable advantages including light weight, low cost, tunable conductivity, environmental stability, and potential for large-scale fabrication. As a result, CPs have found diverse applications in energy storage devices (batteries, supercapacitors), sensors, actuators, electrochromic displays, corrosion protection, and biomedical systems. Recent research focuses on enhancing their processability, mechanical strength, and long-term stability while exploring nanocomposites and hybrid systems for multifunctional applications. Conducting polymers thus serve as a bridge between traditional plastics and advanced electronic materials, holding significant promise for next-generation flexible and sustainable technologies. The objective of this study was to be the innovative pathways in chemical science-conducting polymers at the forefront.
Abstract: Conducting polymers (CPs) represent a unique class of organic materials that combine the electronic and optical properties of metals or semiconductors with the mechanical flexibility and processability of conventional polymers. Conducting polymers are organic polymers that conduct electricity due to conjugated double bonds and doping, offering prop...
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