Observational Case Study on the Effectiveness of the Herbal Decoction Varanadi Kashaya in Managing Obesity of an Individual with Metabolic Disorders
Walpita Kankanamalage Anthoneen Ayesha Thilini Perera,
Nambuhewage Dhammika Namal Jayawardhane
Issue:
Volume 9, Issue 1, March 2023
Pages:
1-6
Received:
24 June 2022
Accepted:
11 July 2022
Published:
9 January 2023
Abstract: Obesity is increasing globally generating serious non-communicable diseases. The antiobesity drugs in the market don’t have any impact on adipocytes; the root cause of obesity, but give rise to many side effects. Several clinical studies have shown the potential of Varanadi Kashaya (VK) mentioned in Ayurveda classic Ashtanga Hrudaya in suppressing adipogenesis and lipid accumulation favoring anti-obesity action without any side effects. Yet, the efficacy of VK in managing obesity in individuals with metabolic disorders has not been evaluated in detail. As the constituents of VK has hypocholesterolemic, anti-diabetic and antioxidant characteristics it can address metabolic disorders as well. This study aims to determine the efficacy of VK in an obese individual with metabolic disorders. Materials and Methods: VK was given for 30 days to an obese person with diabetes and hyperlipidemia and evaluated the changes in anthropometry, Ayurveda parameters and laboratory investigations. Results: High-risk apple shape body shifted into a ratio between apple and pear threshold; a moderate risk to health problems by reducing weight/hip ratio (0.95 to 0.84), LDL (112.6 mg/dl to 106.2 mg/dl), total cholesterol (180 mg/dl to 171 mg/dl) and Non-HDL levels (132 mg/dl to 129 mg/dl) Conclusion: VK has the potency to address both subcutaneous and visceral fat; reducing obesity and controlling obesity-related metabolic disorders.
Abstract: Obesity is increasing globally generating serious non-communicable diseases. The antiobesity drugs in the market don’t have any impact on adipocytes; the root cause of obesity, but give rise to many side effects. Several clinical studies have shown the potential of Varanadi Kashaya (VK) mentioned in Ayurveda classic Ashtanga Hrudaya in suppressing ...
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Integrating In Vivo Model, Molecular Docking and Network Pharmacology to Determine the Mechanism of Theobroma cacao Seed in Treatment of Diarrheal
Maria Fernanda Marin,
Jose Guillermo Mejía,
Alberto Gabriel Flores,
Ana Karla Cuchilla,
Miguel Angel Moreno
Issue:
Volume 9, Issue 1, March 2023
Pages:
7-20
Received:
24 January 2023
Accepted:
10 February 2023
Published:
3 March 2023
Abstract: Theobroma cacao is an economically important tropical-fruit tree where chocolate is obtained, and it is used as traditional medicine worldwide against several diseases. In the present study, in vivo model and computational biology approaches were used to elucidate the potential mechanisms of T. cacao in the treatment of diarrhea. The antidiarrheal and intestinal motility activity was conducted using an animal model induced diarrhea with MgSO4. In addition, an OECD acute oral toxicity test was carried out. Prediction analysis of the bioactive effects of T. cacao against diarrhea symptoms were carried out applying functional enrichment analysis, protein-protein interaction, ADME and drug-likeness analysis, and molecular docking. The analysis of the compound-target- pathway-antidiarrheal mechanism relationships was performed in Cytoscape. T. cacao (200 mg/kg) effectively inhibited diarrhea in mice, significantly lowering the diarrheal stools and intestinal motility, without toxicity signs. Gene set enrichment, molecular docking, and network pharmacology revealed 13 T. cacao compounds targeting 12 proteins that regulate 11 signaling pathways related to diarrhea. According to our research results, the T. cacao antidiarrheal effect could be due to the therapeutic action of quercetin, luteolin, and deoxyclovamide compounds on the ABCB1, ABCG2, CYP3A4, EGFR, ERBB2, IL6, SI, and SLC10A2 genes, related to Carbohydrate digestion and absorption, Bladder cancer, Bile secretion and Graft-versus-host disease as the most significant signaling pathways.
Abstract: Theobroma cacao is an economically important tropical-fruit tree where chocolate is obtained, and it is used as traditional medicine worldwide against several diseases. In the present study, in vivo model and computational biology approaches were used to elucidate the potential mechanisms of T. cacao in the treatment of diarrhea. The antidiarrheal ...
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Phytochemical Screening, Antioxidant, Anti-Inflammatory and Antibacterial Studies on the Stem Bark Extracts of Lannea microcarpa Engl. & K. Krause
Issue:
Volume 9, Issue 1, March 2023
Pages:
21-32
Received:
4 January 2023
Accepted:
30 January 2023
Published:
31 March 2023
Abstract: Medicinal Plants are Plants used for traditional medicines. Any part of the plant could be used as medicine. Medicinal plants have been discovered and used in traditional medicine practices since pre-historical times. A survey of traditional medicine man in Damaturu indicated that Lannia microcarpa is a plants used in the treatment of inflammation, wounds and cancer. The fresh samples (stem bark) of the plant was collected and successively extracted with n-hexane, ethyl acetate, methanol and water. Phytochemical constituents of Lannea microcarpa extracts revealed the presence of cardiac glycosides, flavonoids, saponins, phenols, tannins, alkaloids, sterols and terpenoids. The antioxidant potential was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay, whereas membrane stabilization method was used to evaluate the anti-inflammatory potential of the extracts. The antibacterial potential of the plant extracts against four (4) wound pathogens: Salmonella typhi, Staphylococcus aureus, Escherichia coli and Strephtococcus pneumoneae, was evaluated using disc diffusion technician. The IC50 values obtained for the Lannea microcarpa extracts indicated that the methanol and water extracts exhibited higher antioxidant activities than the standard ascorbic acid. The extracts were found effective in inhibiting the heat induced haemolysis. Diclofenac Sodium salt used as standard drug at 100μg/ml offered 90.66% protection a significant (p<0.05) protection against damaging effect of heat solution. The results showed that all extracts from the plant offered a significant (p<0.05) protection against the damaging effect of hypotonic solution, Diclofenac sodium (100μg/ml), the standard drug offered a significant (p<0.05) protection (57.52%). Lannea microcarpa extracts showed zone of inhibition only against Salmonella typhi and Strephtococcus pneumonea.
Abstract: Medicinal Plants are Plants used for traditional medicines. Any part of the plant could be used as medicine. Medicinal plants have been discovered and used in traditional medicine practices since pre-historical times. A survey of traditional medicine man in Damaturu indicated that Lannia microcarpa is a plants used in the treatment of inflammation,...
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