FAM83D and Malignant Tumors: A Brief Literature Review
Issue:
Volume 8, Issue 2, June 2022
Pages:
53-56
Received:
1 April 2022
Accepted:
19 April 2022
Published:
26 April 2022
DOI:
10.11648/j.bs.20220802.11
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Abstract: Background: FAM83D is a spindle related protein and plays critical roles in mid-plate formation during mitosis. Aberrant FAM83D expression was reported in multiple cancers. Besides, it was observed that FAM83D was capable of promoting the proliferation and migration of normal or cancer cells in several tissues. Objective: we are aiming to update the latest advancement in FAM83D findings, and make a comprehensive review of FAM83D, in order to provide new perspectives for the research of FAM83D in tumors. Methods: Here, we summarized the latest published literatures of FAM83D in recent five years and categorized the research of FAM83D into lung cancer, digestive system cancers and female reproductive cancers. Then, we discussed the relationship of FAM83D and diagnosis, development and prognosis of multiple cancers, as well as the relevant in vitro intracellular underlying mechanisms. Conclusions: Up to now, FAM83D has been investigated in 9 types of cancers and its expression patterns found to tightly related to OS or DFS. Besides, most in vitro studies showed that FAM83D positively regulated cancer cell proliferations and differentiations. Furthermore, researches screened out several downstream targets and intracellular pathways of FAM83D as well as upstream regulatory factors. Prospectively, the biochemistry features of FAM83D protein and its potential as a biomarker of cancer diagnosis or therapy require more independent and rigorous studies.
Abstract: Background: FAM83D is a spindle related protein and plays critical roles in mid-plate formation during mitosis. Aberrant FAM83D expression was reported in multiple cancers. Besides, it was observed that FAM83D was capable of promoting the proliferation and migration of normal or cancer cells in several tissues. Objective: we are aiming to update th...
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The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy
Beatrice Wobiarueri Moore-Igwe,
Ransom Baribefii Jacob,
Serekara Gideon Christian,
Evelyn Mgbeoma Eze
Issue:
Volume 8, Issue 2, June 2022
Pages:
57-62
Received:
17 February 2022
Accepted:
15 March 2022
Published:
31 May 2022
DOI:
10.11648/j.bs.20220802.12
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Abstract: Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K2EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p < 0.001) in the measured parameters. Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.
Abstract: Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively...
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Zinc Deficiency and Anemia in Women of Reproductive Age, Cuba
Ana Maria Gomez-Alvarez,
Gisela Maria Pita-Rodriguez,
Carlos Garcia-Pino,
Angel Mollineda-Trujillo,
Jorge Bacallao-Gallestey,
Lidia Leonor Cardella-Rosales,
Lismery Valdes-Collazo
Issue:
Volume 8, Issue 2, June 2022
Pages:
63-67
Received:
4 April 2022
Accepted:
27 April 2022
Published:
9 June 2022
DOI:
10.11648/j.bs.20220802.13
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Abstract: Anemia, an unresolved health problem in Cuba, has been attributed to iron (Fe) deficiency. There is little information regarding the relationship between anemia, zinc (Zn) deficiency and the effect of inflammation on Fe and Zn deficiencies. It is intended to identify hematological manifestations of anemia, iron and zinc deficiency and its relationship with inflammation in women of reproductive age (WRA) from different provinces of Cuba. An exploratory cross-sectional study was carried out from 2016 to 2018. 654 apparently healthy women aged 18 to 40 years were selected from different provinces of Cuba through multistage cluster sampling. The following were measured: hemoglobin (Hb), ferritin, C-reactive proteins (CRP), alpha glycoprotein (AGP), serum Zn. Ferritin concentrations were adjusted for inflammation using Thurnham's correction factors. International cut-off points were used. The median age was 28 years. Of the women, 18.3% (116/633) had anemia and 18.3% (21/115) of them had Fe deficiency. Adjusting ferritin concentrations for inflammation, the proportion of anemic women with Fe deficiency increased to 22.6% (26/115), and Fe deficiency in the total sample varied from 7.5% (48/639) to 10.0%. (62/639). Serum Zn deficiency was high, 35.7% (234/654), 25.0% of women with Zn deficiency had anemia, with or without inflammation. 42.7% (273/641) women had inflammation. The results suggest an apparent association between anemia and Zn deficiency, a nutritional disorder little studied in Cuba. There is high concordance between the unadjusted and adjusted ferritin concentrations values for inflammation.
Abstract: Anemia, an unresolved health problem in Cuba, has been attributed to iron (Fe) deficiency. There is little information regarding the relationship between anemia, zinc (Zn) deficiency and the effect of inflammation on Fe and Zn deficiencies. It is intended to identify hematological manifestations of anemia, iron and zinc deficiency and its relations...
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