Cell Biology

Volume 7, Issue 1, June 2019

  • Different Functionals Domain of SpastinM87V Affect Cellular Microtubule Cutting

    Yang Yuhao, Zhang Guowei, Ji Zhisheng, Cai Zhenbin, Liu Qiuling, Li Shaojin, Lin Hongsheng

    Issue: Volume 7, Issue 1, June 2019
    Pages: 1-9
    Received: 14 January 2019
    Accepted: 25 February 2019
    Published: 20 March 2019
    Abstract: The research is aimed to explore the effect of different functional domains of SpastinM87V on microtubule cutting of Hela cells. First, the Spastin gene was extracted and its mutants were constructed and identified. Then, Spastin and its mutants were transfected into Hela cells and their cutting effects on microtubules were observed. The results sh... Show More
  • Different Location of Katanin P60 Effect on Cellular Microtubule Cutting

    Li Shaojin, Luo Jianxian, Ji Zhisheng, Yang Yuhao, Zhang Guowei, Tan Minghui, Yang Hua

    Issue: Volume 7, Issue 1, June 2019
    Pages: 10-13
    Received: 12 August 2019
    Accepted: 28 August 2019
    Published: 19 September 2019
    Abstract: Katanin is a heterodimeric hydrolase belonging to the AAA protein family and its function is cutting microtubules. It plays an important role in cell division, neural development, cell migration, and the formation of motor organelles. Katanin has two subunits including katanin p80 and p60. This research is aimed to study the effect of different loc... Show More