Cell Biology

Volume 8, Issue 2, December 2020

  • Mutation of Spastin Affects Microtubule Dynamics Through Differential Distribution

    Liang Zhi, Cai Zhenbin, Zhang Guowei, Tan Minghui, Lin Hongsheng

    Issue: Volume 8, Issue 2, December 2020
    Pages: 22-26
    Received: 21 July 2020
    Accepted: 29 July 2020
    Published: 5 August 2020
    Abstract: SPG4 gene encodes Spastin, and its mutations are the main cause of hereditary spastic paraplegia (HSP). There are more than 50 gene mutations in HSP, and mutations of Spastin account for more than 40%, so SPG4 is the key gene that causes the disease. In order to clarify the effect on microtubule stability after inactivation of AAA functional domain... Show More
  • siRNA-dependent Gene Silencing of EVI1 Decreased Cell Proliferation in MKN45 Cells

    Yuri Na, Hyejun Hwang, Jaehyuk Cho, Woo Rin Lee

    Issue: Volume 8, Issue 2, December 2020
    Pages: 27-32
    Received: 14 September 2020
    Accepted: 29 September 2020
    Published: 16 October 2020
    Abstract: MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in many types of cancer. However, the clinical significance of MECOM in esophagogastric cancer has not been well elucidated. The aim of this study was to define the association of amplification of MECOM and esophagogastric cancer patients’ overall survival rate an... Show More
  • Anti-wrinkle Effect of a Palmitoyl Oligopeptide Complex on Human Keratinocytes and Fibroblasts Through TGF-β1 Pathway

    Yina Lu, Guoxun Wang, Dong Liu, Jun Tian

    Issue: Volume 8, Issue 2, December 2020
    Pages: 33-38
    Received: 29 October 2020
    Accepted: 9 November 2020
    Published: 19 November 2020
    Abstract: Many researchers revealed that dermal fibroblast which mainly synthesis the collagen and elastin in dermis were affects by skin ageing, such as the proliferation rate and gene expression level. Oligopeptides were verified by many reports on anti-aging focus on collagen synthesis, but few literatures revealed the molecular mechanism of oligopeptides... Show More