In the world, cereals especially wheat provides about 50 percent of people’s daily energy requirements. Regretfully, this plant naturally has little micronutrients content and it will be even less if planted in micronutrients poor soils. Moreover, there are anti-nutrient combinations in wheat such as phytic acid that interferes with micronutrients absorption in human body. All of these factors along with low variety of diet result in low intake of daily requirements for micronutrients. Improvement of micronutrients content in wheat grain by bifortification is a proper approach for providing Zn requirements of body and reducing the malnutrition. Biofortification can be carried out by agronomic and genetic biofortification methods. Agronomic approach using micro-nutrient fertilizers, but thisinvolves some technology and costs. On the other hand, genetic biofortification involves classical breeding approaches to characterize and exploit genetic variation for mineral content, as well as new approaches involving gene discovery and marker assisted breeding.

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