Biochemistry and Molecular Biology

Volume 7, Issue 1, March 2022

  • DNMT3A Co-Mutation with SF3B1, ASXL1 and TET2 in Indian Patients with Myelodysplastic Syndrome (MDS)

    Syed Sultan Beevi, Rahul Yadav, Vinod Kumar Verma, Radhika Chowdary Darapuneni, Sukrutha Gopal Reddy, Sujatha Paduval, Sonali Sadawarte, Dharshani Jayashanker

    Issue: Volume 7, Issue 1, March 2022
    Pages: 1-5
    Received: 1 December 2021
    Accepted: 28 December 2021
    Published: 8 January 2022
    Abstract: Myelodysplastic syndrome (MDS) encompasses a diverse group of closely related clonal hematopoietic disorders. Several genes are often mutated in MDS, of which only five (DNMT3A, SF3B1, ASXL1, TET2 and SRSF2) are known to be mutated in >10% of cases. In this perspective, we studied the frequency of somatic mutations in DNMT3A, SF3B1, ASXL1 and TET2 ... Show More
  • The Role of Amino Acid Metabolic Reprogramming in Tumor Development and Immunotherapy

    Safir Ullah Khan, Munir Ullah Khan

    Issue: Volume 7, Issue 1, March 2022
    Pages: 6-12
    Received: 10 January 2022
    Accepted: 24 January 2022
    Published: 9 March 2022
    Abstract: Many amino acid transporters are solvent carrier proteins, which are membrane transport proteins. In order for cells of all kinds to thrive, including cancerous ones, they need a constant supply of amino acids, which are important for growth and development. Tumor cells exhibit considerable metabolic reprogramming as one of their distinguishing cha... Show More
  • Nutrient Content of Traditional Foods Prepared from Yellow Maize (Zea mays L.) Varieties in Ethiopia

    Nibret Mekonen, Henok Nahusenay, Kidist Hailu

    Issue: Volume 7, Issue 1, March 2022
    Pages: 13-17
    Received: 18 February 2022
    Accepted: 15 March 2022
    Published: 23 March 2022
    Abstract: Maize (Zea mays L.) is one of the most important cereal grains for both human food and livestock feed. Ethiopia is among the major maize producers in Africa and ranked fourth next to South Africa, Nigeria and Egypt. Maize production takes significant share of cereals and grain in any production year. The aim of this study was to evaluate the nutrie... Show More