Biochemistry and Molecular Biology

Volume 7, Issue 4, December 2022

  • Nucleoside Reverse Transcriptase Inhibitors Resistance in Children and Adults with Virological Failure in a Context of Systematic Switching to a Dolutegravir-Based Combination

    Dechi Jean-Jacques Renaud, Toni Thomas D'Aquin, Cisse-Camara Massara, N'din Jean-Louis Philippe, Ake Aya Jeanne Armande, Siransy Kouabla Liliane, Sekongo Yassongui Mamadou, Gogbe Leto Olivier, Brou Emmanuel, Fieni Flore, Wawa Amedee Junior, Aby Roland, Kouakou Kouadio, Chenal Henri

    Issue: Volume 7, Issue 4, December 2022
    Pages: 70-74
    Received: 15 September 2022
    Accepted: 4 October 2022
    Published: 17 October 2022
    DOI: 10.11648/j.bmb.20220704.11
    Abstract: Switching to dolutegravir (DTG)-based triple therapy is done without taking into account the level of viral replication and resistance developed by the virus against nucleoside reverse transcriptase inhibitors (NRTIs). The objective of the study was to evaluate the resistance to NRTIs in children and adults with virological failure in Côte d'Ivoire... Show More